Supplementary Figure 3 from Genetic Ablation of the Tetraspanin CD151 Reduces Spontaneous Metastatic Spread of Prostate Cancer in the TRAMP Model

Abstract

<p>PDF file - 112K, Characterisation for expression of the epithelial cell marker cell marker, E-Cadherin. 5 �m FFPE sections of normal prostate glands from 20 week old TRAMP negative animals along with sections from poorly differentiated primary prostate tumours from TRAMP positive animals were characterised by indirect peroxidase IHC with the anti E-Cadherin antibody (clone 36) that labels epithelial cells, as the primary antibody. The epithelial cells in the normal prostate glands in Panel A stained highly and specifically for E-Cadherin both on the membrane and also through the cytoplasm. In Panel B, the prostate gland that displays PIN has reduced labelling of E-cadherin and the surrounding poorly differentiated prostate tumour tissue was void of specific labelling for E-cadherin</p>