Superparamagnetic iron oxides as MPI tracers: A primer and review of early applications

Bulte, Jeff W.M.

doi:10.1016/j.addr.2018.12.007

Cited by 149 publications

(133 citation statements)

References 69 publications

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“…We used ex vivo MPI, but in vivo scans at the same settings are routine. MPI detects only superparamagnetic iron with no anatomy as background, and images have positive contrast, unlike the negative contrast obtained in MRI; the spatial resolution (~1 mm) is currently coarser than that of MRI . Another quantifiable, positive contrast option would be to use a fluorine‐based label and 19 F MRI, which has a similar spatial resolution to MPI.…”

Section: Discussionmentioning

confidence: 99%

“…MPI detects only superparamagnetic iron with no anatomy as background, and images have positive contrast, unlike the negative contrast obtained in MRI; the spatial resolution (~1 mm) is currently coarser than that of MRI. 23 Another quantifiable, positive contrast option would be to use a fluorine-based label and 19 F MRI, 24,25 which has a similar spatial resolution to MPI. One advantage that both MPI and 19 F MRI have over proton MRI is positive contrast and dynamic range.…”

Section: Mri-based Cell Trackingmentioning

confidence: 99%

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Effect of mouse strain and diet on feasibility of MRI‐based cell tracking in the liver

Mallett

Hix

Kiupel

et al. 2019

Magnetic Resonance in Med

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Purpose MRI‐based cell tracking identifies the location of magnetically labeled cells with hypointense voxels. Here we demonstrate a strain‐dependent effect of liver MRI background on the feasibility of MRI‐based cell tracking of transplanted cells in the mouse liver. Methods FVB mice (GFP‐LUC and NOG) and C57BL/6 mice (GFP+ and wild‐type) were fed 3 different diets with varying iron content. In vivo T2∗‐weighted images and T2∗ maps of the liver were acquired at different ages. Magnetically labeled cancer cells were injected intrasplenically for hepatic migration; then, mice were imaged by in vivo MRI and bioluminescence imaging. Livers were also imaged ex vivo by magnetic particle imaging. Results R2∗ increased with age in FVBNOG and FVBGFP‐LUC mice that were fed diets sufficient in iron. FVBNOG mice developed a mottled appearance in their livers with age that did not occur in FVBGFP‐LUC mice. R2∗ was unchanging with age in C57BL/6GFP mice, and the liver remained bright and homogenous. Labeled cells were not detectable by MRI in some livers despite successful engraftment as shown by bioluminescence imaging and magnetic particle imaging. Conclusion Strain, diet, and age are important considerations for MRI‐based cell tracking in the liver. If a model with excessive liver iron must be used, alternative imaging methods such as magnetic particle imaging can be considered.

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Section: Discussionmentioning

confidence: 99%

Section: Mri-based Cell Trackingmentioning

confidence: 99%

Effect of mouse strain and diet on feasibility of MRI‐based cell tracking in the liver

Mallett

Hix

Kiupel

et al. 2019

Magnetic Resonance in Med

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“…Without the presence of an endogenous background signal, MPI can also be used in certain tissues where the endogenous MRI signal is too low to provide contrast. Its applications include MPI cell tracking, multiplexed MPI, perfusion and tumor MPI, lung MPI, and functional MPI [8,18].…”

Section: Diagnostic Applicationsmentioning

confidence: 99%

“…In the last few decades, the use of iron-oxide nanoparticles displaying magnetic properties attracted great interest in many application areas, from magnetic recording media to pharmaceutical applications such as therapy and drug delivery [1][2][3][4][5][6][7][8][9][10][11][12][13][14]. Each application of these nanoparticles needs specific and, sometimes, different properties [1,12,15].…”

Section: Introductionmentioning

confidence: 99%

Pharmaceutical Applications of Iron-Oxide Magnetic Nanoparticles

Bruschi

Toledo

2019

Magnetochemistry

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Advances of nanotechnology led to the development of nanoparticulate systems with many advantages due to their unique physicochemical properties. The use of iron-oxide magnetic nanoparticles (IOMNPs) in pharmaceutical areas increased in the last few decades. This article reviews the conceptual information about iron oxides, magnetic nanoparticles, methods of IOMNP synthesis, properties useful for pharmaceutical applications, advantages and disadvantages, strategies for nanoparticle assemblies, and uses in the production of drug delivery, hyperthermia, theranostics, photodynamic therapy, and as an antimicrobial. The encapsulation, coating, or dispersion of IOMNPs with biocompatible material(s) can avoid the aggregation, biodegradation, and alterations from the original state and also enable entrapping the bioactive agent on the particle via adsorption or covalent attachment. IOMNPs show great potential for target drug delivery, improving the therapy as a consequence of a higher drug effect using lower concentrations, thus reducing side effects and toxicity. Different methodologies allow IOMNP synthesis, resulting in different structures, sizes, dispersions, and surface modifications. These advantages support their utilization in pharmaceutical applications, and getting suitable drug release control on the target tissues could be beneficial in several clinical situations, such as infections, inflammations, and cancer. However, more toxicological clinical investigations about IOMNPs are necessary.

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“…However, some limitations of SPION-based MRI are that SPIONs create a loss of signal and quantitation of signal loss and the number of iron-labelled cells in a particular region is challenging 11 . Magnetic particle imaging (MPI) is an emerging imaging technique that sensitively and specifically detects superparamagnetic iron oxide nanoparticles (SPIONs) [17][18][19] . In MPI, SPIONs result in positive signal and the signal strength is linearly proportional to the number of SPIONs, which allows for truly quantitative imaging.…”

Section: Introductionmentioning

confidence: 99%

Visualizing tumour self-homing with magnetic particle imaging

Parkins¹,

Melo

Ronald

et al. 2020

Preprint

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Due to their innate tumour homing capabilities, in recent years, CTCs have been engineered to express therapeutic genes for targeted treatment of primary and metastatic lesions. Additionally, previous studies have incorporated optical or PET imaging reporter genes to enable noninvasive monitoring of therapeutic CTCs in preclinical tumour models. Here, we demonstrate for the first time, the ability of magnetic particle imaging (MPI) to sensitively detect systemically administered iron-labeled CTCs and to visualize tumour self-homing in a murine model of human breast cancer.

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Superparamagnetic iron oxides as MPI tracers: A primer and review of early applications

Cited by 149 publications

References 69 publications

Effect of mouse strain and diet on feasibility of MRI‐based cell tracking in the liver

Effect of mouse strain and diet on feasibility of MRI‐based cell tracking in the liver

Pharmaceutical Applications of Iron-Oxide Magnetic Nanoparticles

Visualizing tumour self-homing with magnetic particle imaging

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