Superoxide dismutase for preventing chronic lung disease in mechanically ventilated preterm infants

Abstract

Superoxide dismutase for preventing chronic lung disease in mechanically ventilated preterm infants.

Perinatal Risk and Protective Factors in the Development of Diffuse White Matter Abnormality on Term-Equivalent Age Magnetic Resonance Imaging in Infants Born Very Preterm

“…36,37,[53][54][55] The large reduction in BPD incidence noted in randomized trials of postnatal corticosteroids and the lack of benefit observed following antioxidant therapies or tighter control of oxygen saturation suggest that inflammation may be a significant causal factor in the development of BPD. [56][57][58][59][60] Our findings of reduced DWMA following treatment with dexamethasone, a potent anti-inflammatory drug, and caffeine, which also has anti-inflammatory properties, 42,43 further support inflammation as a key mechanism in the development of DWMA. Conversely, we did not observe an association between DWMA and other proinflammatory conditions, such as chorioamnionitis or postnatal sepsis.…”

Perinatal Risk and Protective Factors in the Development of Diffuse White Matter Abnormality on Term-Equivalent Age Magnetic Resonance Imaging in Infants Born Very Preterm

“…36,37,[53][54][55] The large reduction in BPD incidence noted in randomized trials of postnatal corticosteroids and the lack of benefit observed following antioxidant therapies or tighter control of oxygen saturation suggest that inflammation may be a significant causal factor in the development of BPD. [56][57][58][59][60] Our findings of reduced DWMA following treatment with dexamethasone, a potent anti-inflammatory drug, and caffeine, which also has anti-inflammatory properties, 42,43 further support inflammation as a key mechanism in the development of DWMA. Conversely, we did not observe an association between DWMA and other proinflammatory conditions, such as chorioamnionitis or postnatal sepsis.…”

Interventions to Prevent Bronchopulmonary Dysplasia in Preterm Neonates

“…Of 16 025 titles and abstracts screened, 876 full-text articles were assessed, and 154 systematic reviews evaluating 251 different research questions were included in the final umbrella review (eFigure 1 in the Supplement). The characteristics of the included systematic reviews are shown in eTable 2 in the Supplement.…”

Role of Redox in Fetal Development and Neonatal Diseases

“…To add to the confusion, antioxidant therapies to prevent CLD have been met with variable success. Interventions with antioxidant such as recombinant human SOD did not change the incidence of CLD (13,72). Low levels of vitamin A correlated with increased CLD (12).…”

Perinatal Risk and Protective Factors in the Development of Diffuse White Matter Abnormality on Term-Equivalent Age Magnetic Resonance Imaging in Infants Born Very Preterm

“…36,37,[53][54][55] The large reduction in BPD incidence noted in randomized trials of postnatal corticosteroids and the lack of benefit observed following antioxidant therapies or tighter control of oxygen saturation suggest that inflammation may be a significant causal factor in the development of BPD. [56][57][58][59][60] Our findings of reduced DWMA following treatment with dexamethasone, a potent anti-inflammatory drug, and caffeine, which also has anti-inflammatory properties, 42,43 further support inflammation as a key mechanism in the development of DWMA. Conversely, we did not observe an association between DWMA and other proinflammatory conditions, such as chorioamnionitis or postnatal sepsis.…”

Interventions to Prevent Bronchopulmonary Dysplasia in Preterm Neonates

“…Of 16 025 titles and abstracts screened, 876 full-text articles were assessed, and 154 systematic reviews evaluating 251 different research questions were included in the final umbrella review (eFigure 1 in the Supplement). The characteristics of the included systematic reviews are shown in eTable 2 in the Supplement.…”

Role of Redox in Fetal Development and Neonatal Diseases

“…To add to the confusion, antioxidant therapies to prevent CLD have been met with variable success. Interventions with antioxidant such as recombinant human SOD did not change the incidence of CLD (13,72). Low levels of vitamin A correlated with increased CLD (12).…”

Perinatal Risk and Protective Factors in the Development of Diffuse White Matter Abnormality on Term-Equivalent Age Magnetic Resonance Imaging in Infants Born Very Preterm

“…36,37,[53][54][55] The large reduction in BPD incidence noted in randomized trials of postnatal corticosteroids and the lack of benefit observed following antioxidant therapies or tighter control of oxygen saturation suggest that inflammation may be a significant causal factor in the development of BPD. [56][57][58][59][60] Our findings of reduced DWMA following treatment with dexamethasone, a potent anti-inflammatory drug, and caffeine, which also has anti-inflammatory properties, 42,43 further support inflammation as a key mechanism in the development of DWMA. Conversely, we did not observe an association between DWMA and other proinflammatory conditions, such as chorioamnionitis or postnatal sepsis.…”

Interventions to Prevent Bronchopulmonary Dysplasia in Preterm Neonates

“…Of 16 025 titles and abstracts screened, 876 full-text articles were assessed, and 154 systematic reviews evaluating 251 different research questions were included in the final umbrella review (eFigure 1 in the Supplement). The characteristics of the included systematic reviews are shown in eTable 2 in the Supplement.…”

Role of Redox in Fetal Development and Neonatal Diseases

“…To add to the confusion, antioxidant therapies to prevent CLD have been met with variable success. Interventions with antioxidant such as recombinant human SOD did not change the incidence of CLD (13,72). Low levels of vitamin A correlated with increased CLD (12).…”