Superoxide dismutase: a key target for the neuroprotective effects of curcumin

Superoxide dismutase nanozymes: current status and future perspectives on brain disease treatment and diagnosis

“…Vascular dysfunctions, such as reduced cerebral blood flow and disruption of the blood–brain barrier, may also occur. 1 It is often characterized by gradual cognitive impairment and memory loss. The presence of extracellular amyloidbeta (Aβ) peptides in the neocortex is a well-known characteristic of Alzheimer's disease (AD), even if the precise pathomechanism causing AD is still unknown.…”

“…The presence of extracellular amyloidbeta (Aβ) peptides in the neocortex is a well-known characteristic of Alzheimer's disease (AD), even if the precise pathomechanism causing AD is still unknown. 1…”

“…Neurofibrillary tangles, aging plaques, and neuron loss are significant pathogenic hallmarks among the different forms of Alzheimer's disease (AD). 1 Vascular dysfunction can also result in a breakdown of the blood–brain barrier and decreased cerebral blood flow. Furthermore, in AD patients, ROS buildup and mitochondrial dysfunction result in protein-induced toxicity.…”

“…Neurodegenerative disorders (NDDs) are characterized by the loss of neurons in the central nervous system (CNS) that are specific to a disease and can affect different parts of the brain. 1 Genetic mutations can trigger abnormal protein production and aggregation, thereby disrupting neuronal function. Over time, these mutations can lead to the progressive loss of neurons, ultimately resulting in cognitive decline and the manifestation of neurodegenerative symptoms.…”

“…This process is the key mechanism that determines the level of intracellular ROS. 1 When excess free radicals are produced, they can attack cell components such as cell membranes and important molecules such as proteins and DNA, causing oxidative damage and abnormal DNA transcription, leading to cell, tissue and organ damage, inducing various diseases, and accelerating body aging. Antioxidant enzymes like SOD and CAT enzymes are responsible for clearing free radicals and combating the development of brain degenerative diseases.…”