Superior sagittal sinus thrombosis in a child with nephrotic syndrome

Divekar, Abhay; Ali, Uma; Ronghe, Milind; Singh, Aalok R.; Dalvi, Rashmi

doi:10.1007/bf00862081

Cited by 21 publications

(20 citation statements)

References 8 publications

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“…However, the prevalence of thromboembolism in NS is thought to be underestimated [23,52]. Divekar et al have observed a single case of CSVT among 700 hundred consecutive patients with NS [12].…”

Section: Discussionmentioning

confidence: 98%

Cerebral sinovenous thrombosis and idiopathic nephrotic syndrome in childhood: report of four new cases and review of the literature

2006

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Section: Discussionmentioning

confidence: 98%

Cerebral sinovenous thrombosis and idiopathic nephrotic syndrome in childhood: report of four new cases and review of the literature

2006

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“…Divekar et al reported only 1 case of CST out of 700 children with nephrotic syndrome followed over a period of 17 years 6 .…”

Section: Discussionmentioning

confidence: 99%

“…Thrombosis of various vessels has been reported, but CST associated with nephrotic syndrome appears to be very rare and only a few isolated reports exist in the literature [2][3][4][5][6][7][8][9][10][11][12][13] . Divekar et al reported only 1 case of CST out of 700 children with nephrotic syndrome followed over a period of 17 years 6 .…”

Section: Discussionmentioning

confidence: 99%

“…Large amounts of administered heparin may also be lost in the nephrotic urine 16 . Fresh frozen plasma was given to correct antithrombin-3 levels in some reported cases with a good response (reduction of time to achieve the desire anticoagulation level) 2,4,6,12 . The long-term neurologic outcome of sinovenous thrombosis in children is unclear and the best available estimate is that after a mean of 2.1 years, 77 percent of neonates and 52 percent of nonneonates are neurologically normal 19 .…”

Section: Discussionmentioning

confidence: 99%

“…Arterial and venous thromboses are well-recognized classic complications of nephrotic syndrome, however these are far less frequent in children than in adults 1 Cerebral sinovenous thrombosis (CST) associated with nephrotic syndrome in children is extremely rare and only a few isolated reports exist in the literature [2][3][4][5][6][7][8][9][10][11][12][13] .…”

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confidence: 99%

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Cerebral sinovenous thrombosis in a nephrotic child

Rodrigues

Zardini

Andrade

et al. 2003

Arq. Neuro-Psiquiatr.

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-Nephrotic syndrome in infancy and childhood is known to be associated with a hypercoagulable state and thromboembolic complications, but cerebral sinovenous thrombosis (CST) is a very rare and serious one, with only a few isolated reports in the literature. A case is presented of a 9-year-old boy with nephrotic syndrome that acutely developed signs and symptoms of intracranial hypertension syndrome. CST was diagnosed on cranial CT and MRI and he gradually recovered after treatment with anticoagulants. The diagnosis of CST should be considered in any patient with nephrotic syndrome who develops neurologic symptoms. The discussion of this case, coupled with a review of the literature, emphasizes that early diagnosis is essential for institution of anticoagulation therapy and a successful outcome. This report also illustrates the difficulties that may be encountered in managing such a patient.KEY WORDS: cerebral venous thrombosis, sagittal sinus thrombosis, nephrotic syndrome, child. Trombose venosa cerebral em uma criança com síndrome nefróticaRESUMO -A síndrome nefrótica na criança é sabidamente associada a um estado de hipercoagulabilidade e complicações tromboembólicas, entretanto a trombose venosa cerebral (TVC) é uma complicação muito rara e grave, com poucos relatos na literatura. Relatamos o caso de um menino de 9 anos com síndrome nefrótica que agudamente desenvolveu sinais e sintomas de uma síndrome de hipertensão intracraniana. TVC foi diagnosticada através de CT e IRM de crânio e o paciente gradualmente se recuperou após o tratamento com anticoagulantes. O diagnóstico de TVC deve ser considerado em qualquer paciente com síndrome nefrótica que desenvolva sintomas neurológicos. A discussão deste caso, associada à revisão da literatura, enfatiza que o diagnóstico precoce é essencial para instituição da terapia anticoagulante e para o bom prognóstico. Este relato também ilustra a dificuldade em manejar este tipo de paciente. PALAVRAS-CHAVE: trombose venosa cerebral, trombose do seio sagital, síndrome nefrótica, criança.

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Thalamic stroke secondary to straight sinus thrombosis in a nephrotic child

2002

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A 7-year-old Chinese boy with steroid-resistant nephrotic syndrome developed thalamic stroke secondary to straight sinus thrombosis. He was hospitalized due to status epilepticus and coma. The child recovered after treatment by low-molecular-weight heparin (LMWH) and warfarin. This case highlights the importance of magnetic resonance imaging with venography in the early diagnosis of cerebral sinus thrombosis (CST) in nephrotic children and the effectiveness of anticoagulation therapy in improving the neurological outcome.

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Superior sagittal sinus thrombosis in a child with nephrotic syndrome

Cited by 21 publications

References 8 publications

Cerebral sinovenous thrombosis and idiopathic nephrotic syndrome in childhood: report of four new cases and review of the literature

Cerebral sinovenous thrombosis and idiopathic nephrotic syndrome in childhood: report of four new cases and review of the literature

Cerebral sinovenous thrombosis in a nephrotic child

Thalamic stroke secondary to straight sinus thrombosis in a nephrotic child

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