Super bioavailable itraconazole and its place and relevance in recalcitrant dermatophytosis: Revisiting skin levels of itraconazole and minimum inhibitory concentration data

Comparison of Efficacy of Double Dose Oral Terbinafine versus Itraconazole in the Treatment of Dermatophyte Infections of Skin

“…13,14 Still, no single medication outclasses others completely in terms of efficacy and/or safety. 15 Rising trends in resistance to treatment by conventionally used antifungal agents in conventional dosages are of great concern for clinicians. The use of double-dose commercially available oral antifungal medication not only improves the cure rate in the face of emerging antifungal resistance but also shortens the duration of therapy, providing improved efficacy and economy simultaneously.…”

A multicenter, retrospective study to evaluate the effectiveness, safety, and utilization patterns of super bioavailable itraconazole 50 mg in superficial dermatophytic infections

“…6,25 SBitracoazole has shown improved bioavailability profile, less inter-patient variability, and improved efficacy and safety profiles versus conventional itraconazole. 13,20,[26][27][28] Several previous studies have reported a higher effectiveness with SB-itraconazole versus the conventional itraconazole for the treatment of superficial dermatophytic infections. 17,20,22,29 Shenoy et al compared the efficacy and safety of SB-itraconazole (n=26) versus conventional itraconazole (n=33) in an open-label, randomized, double-arm clinical trial.…”

“…In addition, the erratic absorption profile causes wide fluctuations in blood concentration. 13 Furthermore, the prescription patterns of itraconazole may also result in the varied bioavailability. The coadministration of an acidic beverage with itraconazole enhances the bioavailability of itraconazole, particularly in patients receiving acid lowering drugs.…”

“…In India, Intas Pharmaceuticals Limited introduced the SB-itraconazole at a dose of 50 mg post approval by the apex drug regulator 'Drugs Controller General of India (DCGI)'. 13,17 The 50 mg SB-itraconazole is reported to be therapeutically equivalent to 100 mg conventional itraconazole. 12 Several factors such as drug resistance, adherence, dosage forms, drug interactions, co-morbid conditions, or altered pharmacokinetic profiles are known to affect the clinical outcomes in superficial dermatophytic infections and understanding these may help identify the optimal management strategies.…”

Comparative analysis of serum and sebum concentration of super-bioavailable itraconazole 50 versus 65 mg in healthy adult volunteers

“…7 ITZ, being lipophilic in nature, its route of distribution is dependent on sebum and hence determination of sebum concentration becomes critical. 8 Cauwenbergh et al reported ITZ levels in sebum, 2 and 5 times higher than serum levels in back and beard area respectively but with 3 patients only and lack of cut off value for sebum concentration. 6 Though sebum concentration of SB 65 was statistically significant than SB 50 in our study, but due to lack of reference levels for determination of sebum concentration of ITZ, it was difficult to predict preference of one strength over the other.…”