^99mTc‐sestamibi scanning in thyroid nodules with nondiagnostic cytology

Abstract

A negative MIBI scan in a cold nodule accurately excludes malignancy when US-FNAC is reported as nondiagnostic. This avoids the need for more invasive diagnostic procedures (ie, surgery) and positively influences the cost-effectiveness profile. A MIBI scan may be performed by acquiring images 30 minutes after tracer administration alone. Histology is still necessary to distinguish benign from malignant disease in a MIBI-positive nodule but unnecessary surgery could have been reduced from 71 to 8 cases in our series.

Incidental Detection of Thyroid Neoplasm on 99mTc-SestaMIBI Myocardial Perfusion Scan - A Novel Tumour Tracer Revisted

“…99m Tc-MIBI uptake is documented to detect differentiated thyroid carcinoma nodal metastatic spread, breast malignancies, lung malignancies, brain tumors, sarcomas etc. [7] and also medullary carcinoma thyroid [1]. 99m Tc-MIBI scanning was even found to be more sensitive than CT for localizing soft-tissue metastatic disease [8].…”

“…Various radiopharmaceuticals have been seen to detect incidental thyroid nodules. 99m Tc-MIBI has been used in characterization of cold nodules in thyroid especially where FNAC is negative [1] and also in detecting recurrent Medullary Thyroid Carcinoma in patients with calcitonin values in excess of 6000 ng/liter .…”

Diagnostic Accuracy of Elastography and Scintigraphic Imaging After Thermal Microwave Ablation of Thyroid Nodules

“…Additionally, cold nodules then gained scintigraphic 99 m Tc-MIBI imaging prior to and after microwave ablation. 99 m Tc-MIBI is expected to detect malignant thyroid nodules with high sensitivity [19]. In thyroid nodules, previously diagnosed as "indifferent" or "hot", 99 m Tc-pertechnetate imaging was used for scintigraphic imaging after microwave ablation.…”

Cost-effectiveness of 99mTc-MIBI in the evaluation of thyroid nodules for malignancy: a new lease of life for an old radiopharmaceutical?

“…MIBI was first described in the 1980s [1,2]. Originally developed for myocardial perfusion scintigraphy for the detection and localization of coronary artery disease, it went on to eventually achieve registration not only for this indication, but also for the assessment of global ventricular function, scintimammography for the detection of suspected breast cancer when mammography is equivocal, inadequate or indeterminate, and localization of hyperfunctioning parathyroid tissue in patients with recurrent or persistent hyperparathyroidism, both primary and secondary, and in patients with primary hyperparathyroidism scheduled to undergo initial surgery of the parathyroid glands [3].However, for many years it has been known that MIBI scintigraphy can also be used in the diagnostic work-up of scintigraphically cold and therefore suspicious thyroid nodules in combination with fine needle biopsy (FNB) [4][5][6][7][8][9][10][11][12] Tc-pertechnetate thyroid scintigraphy MIBI scintigraphy can achieve a very high negative predictive value ranging from 88 % to 100 % with a mean of 97 %. Furthermore, the sensitivity of MIBI scintigraphy is similarly good with an aggregate value of 96 %.…”

“…However, for many years it has been known that MIBI scintigraphy can also be used in the diagnostic work-up of scintigraphically cold and therefore suspicious thyroid nodules in combination with fine needle biopsy (FNB) [4][5][6][7][8][9][10][11][12] Tc-pertechnetate thyroid scintigraphy MIBI scintigraphy can achieve a very high negative predictive value ranging from 88 % to 100 % with a mean of 97 %. Furthermore, the sensitivity of MIBI scintigraphy is similarly good with an aggregate value of 96 %.…”