2011
DOI: 10.1021/ja2004686
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Abstract: Acetaldehyde is an environmentally widespread genotoxic aldehyde present in tobacco smoke, vehicle exhaust and several food products. Endogenously, acetaldehyde is produced by the metabolic oxidation of ethanol by hepatic NAD-dependent alcohol dehydrogenase and during threonine catabolism. The formation of DNA adducts has been regarded as a critical factor in the mechanisms of acetaldehyde mutagenicity and carcinogenesis. Acetaldehyde reacts with 2'-deoxyguanosine in DNA to form primarily N(2)-ethylidene-2'-de… Show more

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Cited by 61 publications
(54 citation statements)
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“…Indeed, higher aldehyde concentrations seem to interact directly with lipid peroxidation of the cell and induce DNA damage (Garcia et al 2011). Ethanol exposure can also lead to acetaldehyde accumulation, causing bone marrow dysfunction in FA patients (Ghosh et al 2014).…”
Section: Discussionmentioning
confidence: 99%
“…Indeed, higher aldehyde concentrations seem to interact directly with lipid peroxidation of the cell and induce DNA damage (Garcia et al 2011). Ethanol exposure can also lead to acetaldehyde accumulation, causing bone marrow dysfunction in FA patients (Ghosh et al 2014).…”
Section: Discussionmentioning
confidence: 99%
“…They are also highly reactive, being able to form DNA adducts in vitro and in vivo. 63,64 Moreover, FA-deficient cells have been shown to be hypersensitive to both of these compounds and to accumulate double-strand breaks and chromosomal aberrations. [65][66][67][68] Finally, acetaldehyde treatment induces the activation of the FA pathway in wild-type cells.…”
Section: What Is the Cause Of Dna Damage In Hscs?mentioning
confidence: 99%
“…It is possible that some process during development increases the likelihood of exposing cells to a source of aldehyde-mediated DNA damage. Acetaldehyde can cause many forms of DNA damage, including base damage, inter-and intrastrand crosslinks and protein adducts [138][139][140][141]. It will be critical to our understanding of FA to show which of these DNA lesions is repaired by the FA pathway.…”
Section: Fanconi Anaemia and Endogenous Dna Damagementioning
confidence: 99%