Sunscreen photoprotection and vitamin D status

Passeron, Thierry; Bouillon, Roger; Callender, Valerie D.; Cestari, Tânia Ferreira; Diepgen, Thomas L.; Green, Adèle C.; Pols, Jolieke C. van der; Bernard, Bruno; Ly, F.; Bernerd, Françoise; Marrot, Laurent; Nielsen, Mia N.; Verschoore, M.; Jablonski, Nina G.; Young, Antony R.

doi:10.1111/bjd.17992

Cited by 137 publications

(131 citation statements)

References 110 publications

(183 reference statements)

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“…Our data support the use of sunscreens to prevent adverse effects of UVR, without compromising vitamin D synthesis. This is in agreement with the conclusions of two recent reviews of a wide range of different types of studies on the effect of sunscreen use on vitamin D synthesis …”

Section: Discussionmentioning

confidence: 99%

Optimal sunscreen use, during a sun holiday with a very high ultraviolet index, allows vitamin D synthesis without sunburn

et al. 2019

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What's already known about this topic?• Action spectra (wavelength dependence) for erythema and the cutaneous formation of vitamin D overlap considerably in the ultraviolet (UV)B region.• Theoretically, sunscreens that inhibit erythema should also inhibit vitamin D synthesis.The study was approved by the Ethics Committee of the Medical University of Ł od z, Poland and done according to the Declaration of Helsinki. All participants (n = 79) gave written informed consent. Most were of Fitzpatrick skin type (FST) II and III. 32 The group demographics and study locations are summarized in Tables 1 and 2. Briefly, three groups of holidaymakers from Ł od z, Poland, spent a week during March

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Section: Discussionmentioning

confidence: 99%

Optimal sunscreen use, during a sun holiday with a very high ultraviolet index, allows vitamin D synthesis without sunburn

et al. 2019

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“…Modern lifestyle—including indoor living with insufficient sun exposure or the use of sunscreen [ 74 , 75 ] to prevent skin burns and cancer [ 76 ]—can significantly reduce endogenous vitamin D production [ 4 , 12 ]. For this reason, an adequate vitamin D intake through food or supplements became crucial [ 23 , 77 , 78 , 79 ].…”

Section: Vitamin D: State Of the Artmentioning

confidence: 99%

Understanding the Biological Activities of Vitamin D in Type 1 Neurofibromatosis: New Insights into Disease Pathogenesis and Therapeutic Design

Riccardi

Perrone

Napolitano

et al. 2020

Cancers

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Vitamin D is a fat-soluble steroid hormone playing a pivotal role in calcium and phosphate homeostasis as well as in bone health. Vitamin D levels are not exclusively dependent on food intake. Indeed, the endogenous production—occurring in the skin and dependent on sun exposure—contributes to the majority amount of vitamin D present in the body. Since vitamin D receptors (VDRs) are ubiquitous and drive the expression of hundreds of genes, the interest in vitamin D has tremendously grown and its role in different diseases has been extensively studied. Several investigations indicated that vitamin D action extends far beyond bone health and calcium metabolism, showing broad effects on a variety of critical illnesses, including cancer, infections, cardiovascular and autoimmune diseases. Epidemiological studies indicated that low circulating vitamin D levels inversely correlate with cutaneous manifestations and bone abnormalities, clinical hallmarks of neurofibromatosis type 1 (NF1). NF1 is an autosomal dominant tumour predisposition syndrome causing significant pain and morbidity, for which limited treatment options are available. In this context, vitamin D or its analogues have been used to treat both skin and bone lesions in NF1 patients, alone or combined with other therapeutic agents. Here we provide an overview of vitamin D, its characteristic nutritional properties relevant for health benefits and its role in NF1 disorder. We focus on preclinical and clinical studies that demonstrated the clinical correlation between vitamin D status and NF1 disease, thus providing important insights into disease pathogenesis and new opportunities for targeted therapy.

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“…An approach to combat this which appears to be gaining momentum is to promote rigorous sunscreen use. The well‐documented consensus review of Passeron et al . fits this approach and supports it by dismissing any adverse effect on vitamin D, their summary concluding: ‘Sunscreen use for daily and recreational photoprotection does not compromise vitamin D synthesis, even when applied under optimal conditions.’…”

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confidence: 99%