Sunlight exposure, pigmentation factors, and risk of nonmelanocytic skin cancer. II. Squamous cell carcinoma

Gallagher, Richard P.

doi:10.1001/archderm.131.2.164

Cited by 132 publications

(156 citation statements)

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“…Furthermore, skin cancers are not a single entity but different diseases with different sun exposure-related risk factors; for example, early, intermittent overexposure to the sun is thought to be most important for the development of CMM and basal cell carcinoma (BCC; refs. [15][16][17], whereas cumulative sun exposure is thought to be more relevant to SCC (18). Consequently, the skin cancers should be considered individually, rather than as a group (as has been done in some previous studies), because we might reasonably expect to see associations between photosensitizing medications and some forms of skin cancer but not others.…”

Section: Introductionmentioning

confidence: 98%

Photosensitizing Medication Use and Risk of Skin Cancer

Kaae

Boyd

Hansen

et al. 2010

Cancer Epidemiology, Biomarkers &Amp; Prevention

118

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Background: Many commonly used medications, including both medications for long-term (daily) use and short-term use (treatment courses of finite duration), have photosensitizing properties. Whether use of these medications affects skin cancer risk, however, is unclear.Methods: Using a cohort of all Danish residents ≥15 years old in 1995 to 2006 (n = 4,761,749) and information from Danish national registers, we examined associations between use of photosensitizing medications and risk of basal cell carcinoma, cutaneous malignant melanoma, Merkel cell carcinoma, and squamous cell carcinoma.Results: Users of only 2 of 19 medications for long-term use (methyldopa and furosemide) had both a ≥20% increased risk of skin cancer (compared with nonusers) and an increase in risk with increasing duration of use; these effects were limited to basal cell carcinoma and squamous cell carcinoma, respectively. In contrast, 8 of 10 medications for short-term use were associated with both a ≥20% increased risk of skin cancer and an increase in risk with increasing use for at least one of the four cancers.Conclusion: We found little evidence of an increased risk of skin cancer among users of photosensitizing medications for long-term daily use, but could not rule out the possibility that users of some photosensitizing medications for short-term use may have an increased risk of skin cancer.Impact: Previous studies have been limited to specific medication types (e.g., antidiuretics). Our study examined the effect of a wide range of photosensitizing medications on skin cancer risk and suggests that future work should focus on photosensitizing medications for short-term use.

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Section: Introductionmentioning

confidence: 98%

Photosensitizing Medication Use and Risk of Skin Cancer

Kaae

Boyd

Hansen

et al. 2010

Cancer Epidemiology, Biomarkers &Amp; Prevention

118

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“…In addition to the relatively well-known health effects (cataracts, immunosuppression, and skin cancer) on human beings (Bergmanson et al, 1996;Cullen and Perera, 1994;Gallagher et al, 1995aGallagher et al, , 1995bGarssen et al, 1996), increases in surface UV-B irradiance (resulting from the well-known decline in total column ozone) may have deleterious effects on a great variety of species, such as the phytoplankton in the oceans that are the base of the marine food web (Cullen and Neale, 1994), nitrogen-fixing bacteria in rice paddies (Banerjee and Häder, 1996), food crops (Krupa and Kickert, 1989;Greenberg, 1993a, 1993b), forests (Laakso and Huttunen, 1998) and aquatic ecosystems (Pienitz and Vincent, 2000; † Incident energy per unit area per unit time, from all directions (units W m -2 ), as opposed to radiance, which is incident energy per unit solid angle per unit area per unit time (units W sr -1 m -2 ). Spectral irradiance is incident energy per unit area per unit time per wavelength interval (units W m -2 nm -1 ).…”

Section: Introductionmentioning

confidence: 99%

Climatology and trends of surface UV radiation: Survey article

Tarasick¹,

Fioletov

Wardle

et al. 2003

Atmosphere-Ocean

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An improved understanding of the global ultraviolet (UV) climate has recently become of great interest. A number of stations are now making regular measurements of spectrally-resolved UV-B irradiance. Despite the lack of long-term records RÉSUMÉ [traduit par la rédaction] On cherche récemment à améliorer nos connaissances de la climatologie mondiale de l'ultraviolet (UV). Plusieurs stations mesurent périodiquement l'irradiance UV-B résolue spectralement. Malgré la pénurie de données à long terme, il est possible de décrire la climatologie à court terme de l'irradiance UV-B au sol ainsi que plusieurs de ses caractéristiques et des facteurs dont elle dépend. Le présent article décrit l'état actuel des mesures des UV-B et présente une climatologie de l'irradiance UV-B au sol, notamment pour le Canada. L'irradiance UV est fonction de l'ozone et d'autres variables climatiques; cette relation est examinée en détail en faisant appel aux observations. Une comparaison des résultats fournis par les modèles de transfert radiatif et des mesures récentes révèle qu'il est possible d'inférer l'irradiance UV-B à la surface à partir d'enregistrements plus anciens de l'ozone total et de mesures accessoires (irradiance avec IntroductionThe ultraviolet (UV) solar spectrum is, by common convention, divided into three regions. Solar radiation of less than 280 nm wavelength (the UV-C region) is so strongly absorbed by ozone and (at shorter wavelengths) molecular oxygen that it is undetectable at the Earth's surface. Surface UV irradiance † therefore consists of UV-A (315-400 nm) and UV-B (280-315 nm). While the former comprises a much larger portion of the total solar energy (7% of the extraterrestrial solar constant versus 1.5% for the UV-B portion) it has much less capacity to affect biological systems because the individual photons themselves are less energetic.

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“…The major environmental risk factor for all skin cancers is exposure to ultraviolet (UV) radiation, although the precise patterns and timing of sun exposure and its relation to skin cancer risk differ between these three main skin cancer types and also depend on geographical location and population. [3][4][5][6] Development of skin cancer is also closely related to pigmentary traits (higher risks for fair-skinned people with eye and hair colour also repeatedly shown to be related to skin cancer risk). 7,8 Many other risk factors for skin cancer have been postulated, including smoking, alcohol consumption, exposure to arsenic, coal-tar products and psoralens, obesity (body mass index ‡ 30 kg m ), medication use, certain dietary components, major (chronic) stress and certain medical conditions and genetic syndromes.…”

mentioning

confidence: 99%

Known and potential new risk factors for skin cancer in European populations: a multicentre case-control study

Vries

Trakatelli

Kalabalikis

et al. 2012

British Journal of Dermatology

140

111

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BACKGROUND: \ud \ud During recent years numerous studies have suggested that personal and environmental factors might influence cancer development.\ud \ud OBJECTIVES: \ud \ud To investigate environmental and personal characteristics associated with skin cancer risk.\ud \ud METHODS: \ud \ud A multicentre hospital-based case-control study was performed in Finland, Germany, Greece, Italy, Malta, Poland, Scotland and Spain, including 409 patients with squamous cell carcinoma (SCC), 602 with basal cell carcinoma (BCC) and 360 with cutaneous malignant melanoma (CMM) and 1550 control persons. Exposures were assessed by questionnaires that were partly self-administered, partly completed by dermatologists. Unconditional logistic regression modelling was used to assess associations including the influence of certain drugs and food items on skin cancer risk.\ud \ud RESULTS: \ud \ud The usual associations were observed for sun exposure and pigmentation characteristics, with chronic sun exposure being most strongly associated with SCC risk, and naevi and atypical naevi with CMM risk. Use of ciprofloxacin was associated with a decreased risk of BCC [odds ratio (OR) 0·33] and use of thiazide diuretics was associated with an increased risk of SCC (OR 1·66). Ciprofloxacin was also associated with SCC (OR 0·34) and thiazines with BCC (OR 2·04), but these associations lost significance after correction for multiple testing. Consumption of pomegranate, rich in antioxidants, was associated with decreased BCC and SCC risk, also after correcting for multiple testing. Recent experience of stressful events was associated with increased risk, particularly of CMM.\ud \ud CONCLUSIONS: \ud \ud In this large case-control study from across Europe the expected associations were observed for known risk factors. Some new potential protective factors and potential risk factors were identified for consumption of certain food items, medication use and stress, which deserve further investigation in future studies

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Sunlight exposure, pigmentation factors, and risk of nonmelanocytic skin cancer. II. Squamous cell carcinoma

Cited by 132 publications

References 0 publications

Photosensitizing Medication Use and Risk of Skin Cancer

Photosensitizing Medication Use and Risk of Skin Cancer

Climatology and trends of surface UV radiation: Survey article

Known and potential new risk factors for skin cancer in European populations: a multicentre case-control study

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