Abstract:Context
: Central precocious puberty (CPP) results from premature activation of the hypothalamic–pituitary–gonadal axis. Loss-of-function mutations in makorin ring finger 3 (
MKRN3
), a maternally imprinted gene, have been recognized as the most common genetic cause of CPP. More recently, a complex defect (deletion and duplication) in delta-like 1 homolog (
DLK1
), another maternally imprinted gene, was associated with CPP and increased body fat in a fam… Show more
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