2021
DOI: 10.1007/s00018-021-03826-6
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SUMOylation modulates the stability and function of PI3K-p110β

Abstract: We thank Dr Jonathan M Backer for kindly providing the myc-p110b plasmid and Dr Lewis Cantley for the HA-tagged p110a expression plasmid. Funding at the laboratory of CR is provided by Ministry of Science, Innovation and Universities and FEDER (BFU-2017-88880-P) and Xunta de Galicia (ED431G 2019/02). SV and RS are predoctoral fellows funded by Xunta de Galicia-Consellería de Cultura, Educación y Ordenación Universitaria (ED481A-2018/110 and ED481A-2020/160, respectively).

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Cited by 12 publications
(10 citation statements)
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“…These results agree with the observation that SUMOylation regulates protein stability by antagonizing ubiquitination either in the same lysine as can be the case for SAM residues or by other mechanisms that might include steric hindrance. Enhanced protein stability by SUMOylation has been documented in several proteins, including PI3K p110 catalytic subunit [ 37 ], tau [ 33 ], phosducin [ 38 ], and the transcription factor Nrf2 [ 39 ]. However, in the case of the TJ protein claudin-2, its expression level and membrane localization diminished when SUMO-1 was stably expressed [ 40 ].…”
Section: Discussionmentioning
confidence: 99%
“…These results agree with the observation that SUMOylation regulates protein stability by antagonizing ubiquitination either in the same lysine as can be the case for SAM residues or by other mechanisms that might include steric hindrance. Enhanced protein stability by SUMOylation has been documented in several proteins, including PI3K p110 catalytic subunit [ 37 ], tau [ 33 ], phosducin [ 38 ], and the transcription factor Nrf2 [ 39 ]. However, in the case of the TJ protein claudin-2, its expression level and membrane localization diminished when SUMO-1 was stably expressed [ 40 ].…”
Section: Discussionmentioning
confidence: 99%
“…PI3K is composed of one catalytic (p110) domain and one regulatory (p85) domain. 32 , 33 p85, which contains the Src homology 2 (SH2) and SH3 protein-binding domains, 34 , 35 can interact with target proteins with corresponding binding sites. The activation of PI3K mainly involves the binding of the substrate near the inner side of the plasma membrane.…”
Section: The Pi3k/akt Signaling Pathway In Tumorigenesismentioning
confidence: 99%
“…The SUMOylation of proteins is regulated by multiple signaling pathways including mitogenactivated protein kinase (MEK), extracellular signalregulated kinase (ERK) and phosphatidylinositol 3-kinase (PI3K) [27][28][29]. Synthetic SUMOylation inhibitors (e.g., TAK-981) were evaluated for activating IFN1 signaling pathway and controlling DNA damage response and gene transcription [30,31].…”
Section: Ivyspring International Publishermentioning
confidence: 99%