Summer–winter differences of PM2.5 toxicity to human alveolar epithelial cells (A549) and the roles of transition metals

Chen, Yan; Luo, Xiao-San; Zhao, Zhen; Chen, Qi; Wu, Di; Sun, Xue; Wu, Li-Chun; Liu, Jin

doi:10.1016/j.ecoenv.2018.09.034

Cited by 74 publications

(33 citation statements)

References 30 publications

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“…Due to their high toxicity, As, Cd, Hg, and Pb rank among the top 10 priority substances that are of public health concern ([12]-2018). Other priority elements for human health concern, and of particular relevance when considering exposure to metalliferous mine dust, include U and the transition metals Co, Cu, Ni and Zn due to their ability to generate reactive oxygen species (ROS) in biological tissues via Fenton-type reactions [25,48,63]. The Fenton reaction refers to the reaction between hydrogen peroxide and ferrous salts to produce a reactive species capable of oxidising a wide variety of organic substrates.…”

Section: Source and Environmental Pathways Of Metalliferous Mine Dustsmentioning

confidence: 99%

Metalliferous Mine Dust: Human Health Impacts and the Potential Determinants of Disease in Mining Communities

et al. 2019

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Purpose of Review Many factors influence the health impact of exposure to metalliferous mine dusts and whilst the underpinning toxicology is pivotal, it is not the only driver of health outcomes following exposure. The purpose of this review is twofold: (i) to highlight recent advances in our understanding of the hazard posed by metalliferous mine dust and (ii) to broaden an often narrowly framed health risk perspective to consider the wider aetiology of the potential determinants of disease. Recent Findings The hazard posed by metalliferous dusts depends not only on their abundance and particle size but other properties such as chemical composition, solubility, shape, and surface area, which all play a role in the associated health effects. A better understanding of the mechanisms that lead to toxicity, such as recent advances in our understanding of the role played by reactive oxygen species (ROS), can help in the development of improved in vitro models to support risk assessments, whilst biomonitoring studies have the potential to guide risk management decisions for mining communities. Summary Environmental exposures are complex; complex geochemically and complex geographically. Research linking the environment to human health is starting to mature, highlighting the subtlety of multiple exposures, mixtures of substances, and the cumulative legacy effects of life in disrupted and stressed environments. We are evolving more refined biomarkers to identify these responses, which enhances our appreciation of the burden of effects on society and also directs us to more sophisticated risk assessment approaches to adequately address evolving regulatory and societal needs.

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Section: Source and Environmental Pathways Of Metalliferous Mine Dustsmentioning

confidence: 99%

Metalliferous Mine Dust: Human Health Impacts and the Potential Determinants of Disease in Mining Communities

et al. 2019

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“…Epidemiological studies have shown that PM is associated with increased disease morbidity and mortality, especially heart and lung diseases. PM has become the primary pollutant in the ambient air of China, typically as PM 2.5 [3]. PM 2.5 refers to atmospheric particles with an aerodynamic diameter less than or equal to 2.5 µm.…”

Section: Introductionmentioning

confidence: 99%

Seasonal Levels, Sources, and Health Risks of Heavy Metals in Atmospheric PM2.5 from Four Functional Areas of Nanjing City, Eastern China

Luo

et al. 2019

Atmosphere

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Aerosol pollution is a serious environmental issue, especially in China where there has been rapid urbanization. To identify the intra-annual and regional distributions of health risks and potential sources of heavy metals in atmospheric particles with an aerodynamic diameter less than or equal to 2.5 μm (PM2.5), this work collected monthly PM2.5 samples from urban, industrial, suburban, and rural areas in Nanjing city during 2016 and analyzed the heavy metal compositions (Cu, Pb, Cd, Co, V, Sr, Mn, Ti, and Sb). Enrichment factors (EFs) and principal component analysis (PCA) were applied to investigate the sources. The atmospheric PM2.5 pollution level was highest in the industrial area, followed by the urban and suburban areas, and was the lowest in the rural area. Seasonally, the concentrations of PM2.5 and associated heavy metals in spring and winter were higher than those in summer and autumn. Besides natural sources, heavy metal pollution in PM2.5 might come from metallurgical dust in the industrial area, while it mainly comes from automobile exhaust in urban and suburban areas. Health risk assessments revealed that noncancerous hazards of heavy metals in PM2.5 were low, while the lifetime cancer risks obviously exceeded the threshold. The airborne metal pollution in various functional areas of the city impacted human health differently.

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“…Because of the complexity of PM 2.5 , in this study we only considered PM 2.5 as a whole with a preliminary discussion on its effect on Ca 2+ signaling responses in T lymphocytes. Currently, more and more studies have begun to study the mechanisms of toxicity of PM 2.5 components from a microscopic perspective (Chen et al, 2018; Li et al, 2019; Zou et al, 2016). Thus further studies are needed to determine which components are involved in IP3 R and RyR channels opening.…”

Section: Discussionmentioning

confidence: 99%

IP3R and RyR channels are involved in traffic-related PM_2.5-induced disorders of calcium homeostasis

et al. 2019

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Traffic-related PM 2.5 can result in immune system damage and diseases; however, the possible mechanism of its effect remains unclear. Calcium (Ca 2þ) is a critical signaling molecule in a variety of cells. Indeed, Ca 2þ is involved in numerous basic functions, including cell growth and death. In this study, Jurkat T cells were used to explore the possible mechanisms of PM 2.5-elicited intracellular Ca 2þ signal responses. The results indicate that PM 2.5 could raise the level of intracellular Ca 2þ concentration ([Ca 2þ ]i). The [Ca 2þ ]i in Jurkat T cells significantly decreased after treatment with heparin as an inhibitor of inositol trisphosphate receptors (IP3 R), or procaine as an inhibitor of ryanodine receptors (RyR). The expression of calmodulin (CAM) protein decreased in a time-dependent manner after exposure to PM 2.5 , whereas the activity of Ca 2þ-Mg 2þ-ATPase seemed to show a slight drop trend after exposure to PM 2.5. Our findings demonstrate that PM 2.5 stimulation to Jurkat T cells would result in an increase in [Ca 2þ ]i, which is modulated by IP3 R and RyR, as well as CAM.

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Summer–winter differences of PM2.5 toxicity to human alveolar epithelial cells (A549) and the roles of transition metals

Cited by 74 publications

References 30 publications

Metalliferous Mine Dust: Human Health Impacts and the Potential Determinants of Disease in Mining Communities

Metalliferous Mine Dust: Human Health Impacts and the Potential Determinants of Disease in Mining Communities

Seasonal Levels, Sources, and Health Risks of Heavy Metals in Atmospheric PM2.5 from Four Functional Areas of Nanjing City, Eastern China

IP3R and RyR channels are involved in traffic-related PM_2.5-induced disorders of calcium homeostasis

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Summer–winter differences of PM2.5 toxicity to human alveolar epithelial cells (A549) and the roles of transition metals

Cited by 74 publications

References 30 publications

Metalliferous Mine Dust: Human Health Impacts and the Potential Determinants of Disease in Mining Communities

Metalliferous Mine Dust: Human Health Impacts and the Potential Determinants of Disease in Mining Communities

Seasonal Levels, Sources, and Health Risks of Heavy Metals in Atmospheric PM2.5 from Four Functional Areas of Nanjing City, Eastern China

IP3R and RyR channels are involved in traffic-related PM2.5-induced disorders of calcium homeostasis

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IP3R and RyR channels are involved in traffic-related PM_2.5-induced disorders of calcium homeostasis