Sulphasalazine in rheumatoid arthritis.

McConkey, B; Amos, R S; Durham, Stephen K.; Forster, P.; Hubball, S; Walsh, Linda

doi:10.1136/bmj.280.6212.442

Cited by 156 publications

(28 citation statements)

References 10 publications

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“…Nevertheless they both appear to produce significant clinical improvement in rheumatoid patients [19,20,21,22,28]. High doses of dapsone (100-150 mg/kg) failed to have any therapeutic effect on adjuvant arthritis in rats [29]; some activity was observed with a prophylactic schedule but this may have been due to gross toxicity of the compound.…”

Section: Discussionmentioning

confidence: 95%

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Pharmacological studies of antigen-induced arthritis in BALB/c mice II. The effects of second-line antirheumatic drugs and cytotoxic agents on the histopathological changes

1986

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The effects of treatment with second-line antirheumatic drugs and cytotoxic agents on the severity of experimental monoarticular arthritis in BALB/c mice have been investigated. The arthritis was assessed histologically in terms of synovitis and erosions of cartilage and bone. Azathioprine (20 mg/kg) and sulphasalazine (10-30 mg/kg oral; 30-100 mg/kg i.p.) produced significant suppression of synovitis and erosions when administered daily for 4 weeks commencing 2 weeks after induction of the arthritis. Dapsone (1-10 mg/kg) and to a lesser extent methotrexate (2 mg/kg) produced some suppression of erosive disease when administered daily for 4 weeks commencing 2 weeks after induction of the arthritis but this failed to reach statistical significance. Chloroquine, D-penicillamine and sodium aurothiomalate all failed to have any effect on the disease with any of the treatment schedules used. Auranofin had no effect on the disease when treatment commenced 2 weeks after intra-articular injection but produced variable suppression at high doses when administered from the day of intra-articular injection.

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Section: Discussionmentioning

confidence: 95%

“…In addition, we have investigated the activity of the orally active gold compound auranofin and two drugs which are being used increasingly for the treatment of rheumatoid arthritis, namely dapsone and sulphasalazine [19,20,21,22]. Two cytotoxic agents, azathioprine and methotrexate, have also been examined.…”

Section: Introductionmentioning

confidence: 99%

Pharmacological studies of antigen-induced arthritis in BALB/c mice II. The effects of second-line antirheumatic drugs and cytotoxic agents on the histopathological changes

1986

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“…However, due to the discovery of corticosteroids in 1949 and the increased interest in gold and penicillamine, SASPs did not become the preferred RA treatment until the 1980s. In a study published in 1980, McConkey et al restored the use of SASPs for the treatment of RA [36].…”

Section: Sulfasalazinementioning

confidence: 99%

Oral Bacteria Are Responsible for the Etiology of Rheumatoid Arthritis

Öğrendik¹

2014

OJRA

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A significant association has been shown to exist between periodontitis and rheumatoid arthritis (RA) in observational studies. Some intervention studies have suggested that periodontal treatment can reduce serum inflammatory biomarkers such as C-reactive protein, or erythrocyte sedimentation rate. Serum antibodies to oral bacteria have been found at increased levels in RA patients. In addition, DNAs from these bacteria have been identified from samples of RA patients. Several antibiotics are effective on RA. Finally, oral bacteria are responsible for the etiology of RA.

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“…It also has been found to be effective in the treatment of rheumatoid arthritis (13,14), and its beneficial effect has been observed in reactive synovitis and in AS with peripheral arthritis (15). In 2 recent double-blind controlled studies using enteric-coated sulfasalazine, AS patients showed good clinical response (16,17).…”

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confidence: 99%

Sulfasalazine in the treatment of ankylosing spondylitis

Nissilä

Lehtinen

Leirisalo‐Repo

et al. 1988

Arthritis & Rheumatism

111

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Eighty-five patients with active ankylosing spondylitis (AS) were randomized to receive either sulfasalazine ( 5 3 gm/day, mean 2.5) or placebo for 26 weeks. There was a statistically significant improvement, compared with baseline, in most of the clinical variables in patients receiving the active drug. Laboratory parameters (erythrocyte sedimentation rate, Creactive protein, IgG, IgM, and IgA) also improved during the active treatment, suggesting a beneficial effect of sulfasalazine on AS. At the end of the treatment, significant differences between the sulfasalazine and placebo groups were observed in morning stiffness, chest expansion, erythrocyte sedimentation rate, and in all immunoglobulin classes. Two patients in each treatment group discontinued the trial because of side effects. Enteric-coated sulfasalazine seemed to be effective and well tolerated in patients with active AS.Ankylosing spondylitis (AS) is one of the HLA-B27-associated diseases (1). In some of these diseases, infection is considered to be an etiologic factor.To date, however, the role of infection in the etiology of AS has not been confirmed. The association beFrom the Rheumatism Foundation

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Sulphasalazine in rheumatoid arthritis.

Cited by 156 publications

References 10 publications

Pharmacological studies of antigen-induced arthritis in BALB/c mice II. The effects of second-line antirheumatic drugs and cytotoxic agents on the histopathological changes

Pharmacological studies of antigen-induced arthritis in BALB/c mice II. The effects of second-line antirheumatic drugs and cytotoxic agents on the histopathological changes

Oral Bacteria Are Responsible for the Etiology of Rheumatoid Arthritis

Sulfasalazine in the treatment of ankylosing spondylitis

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