Sulfonate-modified phenylboronic acid-rich nanoparticles as a novel mucoadhesive drug delivery system for vaginal administration of protein therapeutics: improved stability, mucin-dependent release and effective intravaginal placement

Li, Chunyan; Huang, Zhigang; Liu, Zheshuo; Ci, Li-qian; Liu, Zhepeng; Liu, Yu; Yan, Xueying; Lu, Weiyue

doi:10.2147/ijn.s113658

Cited by 14 publications

(14 citation statements)

References 35 publications

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“…In addition to assessing surface modifications and delivery conditions, different polymeric delivery vehicles have been evaluated in murine models. 23 A novel formulation, composed of phenylboronic NPs, was studied to improve NP mucoadhesion within the FRT. 23 Due to the affinity of phenylboronic acid to form stable cyclic ester bonds with mucin, phenylboronic acid rich-NPs (PBNPs) were seen as an attractive option to formulate mucoadhesive delivery vehicles.…”

Section: Effects Of Polymer Type On In Vivo Transportmentioning

confidence: 99%

“…23 A novel formulation, composed of phenylboronic NPs, was studied to improve NP mucoadhesion within the FRT. 23 Due to the affinity of phenylboronic acid to form stable cyclic ester bonds with mucin, phenylboronic acid rich-NPs (PBNPs) were seen as an attractive option to formulate mucoadhesive delivery vehicles. Moreover, it was believed that modifying PBNPs with sodium sulfate would increase colloidal stability and form stable bonds with mucin fibers.…”

Section: Effects Of Polymer Type On In Vivo Transportmentioning

confidence: 99%

“…These modifications can either enhance NP diffusion through the CVM via muco-inert properties, or can impart mucoadhesive characteristics for greater longevity in the basal mucus layer ( Figure 2). 5,18,19,23,31,32,36,[38][39][40] Therefore, NPs can directly carry therapeutic payloads and navigate through the porous CVM, thereby increasing agent penetration and transport. Moreover, alterations in physicochemical properties can be adapted to attain desired pharmacokinetic (PK) and pharmacodynamic (PD) properties.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, alterations in physicochemical properties can be adapted to attain desired pharmacokinetic (PK) and pharmacodynamic (PD) properties. 6,7,10,14,15,19,23,26,27,36,39,41 Thus, polymeric NPs can be designed to overcome transport barriers and to deliver effective doses to target sites, while maintaining agent activity and minimizing adverse effects on surrounding tissue.…”

Section: Introductionmentioning

confidence: 99%

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Nanoparticle-mediated drug delivery to treat infections in the female reproductive tract: evaluation of experimental systems and the potential for mathematical modeling

Sims¹,

Frieboes²,

Steinbach-Rankins³

2018

IJN

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A variety of drug-delivery platforms have been employed to deliver therapeutic agents across cervicovaginal mucus (CVM) and the vaginal mucosa, offering the capability to increase the longevity and retention of active agents to treat infections of the female reproductive tract (FRT). Nanoparticles (NPs) have been shown to improve retention, diffusion, and cell-specific targeting via specific surface modifications, relative to other delivery platforms. In particular, polymeric NPs represent a promising option that has shown improved distribution through the CVM. These NPs are typically fabricated from nontoxic, non-inflammatory, US Food and Drug Administration-approved polymers that improve biocompatibility. This review summarizes recent experimental studies that have evaluated NP transport in the FRT, and highlights research areas that more thoroughly and efficiently inform polymeric NP design, including mathematical modeling. An overview of the in vitro, ex vivo, and in vivo NP studies conducted to date – whereby transport parameters are determined, extrapolated, and validated – is presented first. The impact of different NP design features on transport through the FRT is summarized, and gaps that exist due to the limitations of iterative experimentation alone are identified. The potential of mathematical modeling to complement the characterization and evaluation of diffusion and transport of delivery vehicles and active agents through the CVM and mucosa is discussed. Lastly, potential advancements combining experimental and mathematical knowledge are suggested to inform next-generation NP designs, such that infections in the FRT may be more effectively treated.

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Section: Effects Of Polymer Type On In Vivo Transportmentioning

confidence: 99%

Section: Effects Of Polymer Type On In Vivo Transportmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Nanoparticle-mediated drug delivery to treat infections in the female reproductive tract: evaluation of experimental systems and the potential for mathematical modeling

Sims¹,

Frieboes²,

Steinbach-Rankins³

2018

IJN

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“…Irritation of the treated groups was demonstrated by comprehensive irritation index (Dover et al, 2007;Bachhav & Patravale, 2009;Li et al, 2016) (shown in supplemental material).…”

Section: In Vivo Irritation Testmentioning

confidence: 99%

Expansible thermal gelling foam aerosol for vaginal drug delivery

Mei

Chen

et al. 2017

Drug Delivery

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Vaginal delivery of antimicrobial drugs is the most effective method for the local treatment of the vaginal infections. However, current vaginal drug delivery systems (VDDS), including gel, lotion, aerosol and cream, are suffering from low penetration in the deep vaginal rugae and easy elimination by self-cleaning of vaginal canal. To address these issues, a foam aerosol based on the thermal transformation was designed to improve penetration efficiency and achieve the extended retention. The expansible thermal gelling foam aerosol (ETGFA) consisting of thermal sensitive matrix, silver nanoparticle, adhesive agent and propellant, was optimized by evaluations of precursor viscosity, foam expansion, thermal gelation, gel adhesiveness, antimicrobial effects and tissue irritation. The ETGFA would penetrate to the deep vaginal rugae to cover the infectious sites by foam expansion. Drug leakage was intended to be avoided by the thermal gelation at physiological temperature before foam collapse. The gel could be retained in the vaginal canal for extended time due to its superior adhesiveness when compared to the commercial gel Asimi V R . The ETGFA provided extended drug release for over 4 h and maintained effective drug concentrations at the infectious sites. The ETGFA containing silver nanoparticles showed dose-dependent antimicrobial effects on the vaginal floras and irritation reduction to the vaginal tissues. The results demonstrated that the ETGFA could overcome the limitations of conventional dosage forms, including poor drug penetration, carrier retention and patient compliance and satisfied the requirements for vaginal drug delivery. ARTICLE HISTORY

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Phenylboronic acid-functionalized gelatin–oleic acid nanoparticles for high loading and efficient transdermal delivery of Celastrol towards the treatment of psoriasis

Su,

Lin,

You

et al. 2023

Macromol. Res.

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Sulfonate-modified phenylboronic acid-rich nanoparticles as a novel mucoadhesive drug delivery system for vaginal administration of protein therapeutics: improved stability, mucin-dependent release and effective intravaginal placement

Cited by 14 publications

References 35 publications

Nanoparticle-mediated drug delivery to treat infections in the female reproductive tract: evaluation of experimental systems and the potential for mathematical modeling

Nanoparticle-mediated drug delivery to treat infections in the female reproductive tract: evaluation of experimental systems and the potential for mathematical modeling

Expansible thermal gelling foam aerosol for vaginal drug delivery

Phenylboronic acid-functionalized gelatin–oleic acid nanoparticles for high loading and efficient transdermal delivery of Celastrol towards the treatment of psoriasis

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