Sulfonate-functionalized tetraphenylethylenes for selective detection and wash-free imaging of Gram-positive bacteria (<i>Staphylococcus aureus</i>)

Naik, Viraj G.; Hiremath, Sharanabasava D.; Das, Avijit; Banwari, Dishant; Gawas, Ram U.; Biswas, Malabika; Banerjee, Mainak; Chatterjee, Amrita

doi:10.1039/c8qm00417j

Cited by 28 publications

(20 citation statements)

References 76 publications

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“…In general, AIE‐sulfonates are non‐emissive in aqueous solution but fluoresce strongly in the aggregated state, either by the formation of water‐dispersible aggregates or by adhering onto solid surfaces (e. g. cell‐wall of bacteria) (Figure 2a) [35,38,44,45] . The aqueous solubility of AIE‐sulfonates increases with the increasing number of −SO 3 − functionalities in the molecule.…”

Section: General Properties and Characterization Techniquesmentioning

confidence: 99%

Sulfonate‐Functionalized AIEgens: Strategic Approaches Beyond Water Solubility for Sensing and Imaging Applications

2022

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The development of water-soluble aggregation-induced emission (AIE)-active "light-up" probes for sensing and imaging purposes has drawn immense research attention in the recent past. One strategy has been to introduce À SO 3 À groups in AIEgens (AIE-sulfonates) to increase their hydrophilic properties, and the ionic nature of the corresponding compounds also paves the way for electrostatic interaction with various analytes, in particular, with several biospecies having positively charged surfaces. A significant number of AIE-sulfonates, many among them having a tetraphenylethylene (TPE) moiety, have been designed and synthesized for the selective detection of a variety of analytes, such as metal ions, small molecules, enzymes, proteins, and bacteria. The strategies for selective detection include, for example, spontaneous complex formation with cations, electrostatic interaction with target-specific units in the biospecies, and strong hydrophobic interactions. In addition, these AIEgens are used in cell imaging and OLED applications. This Review attempts to provide a summary and discuss recent developments in sulfonate-functionalized AIEactive "light-up" probes in sensing and imaging applications with a focus on the role of the sulfonate functionality in the design and sensing processes.

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Section: General Properties and Characterization Techniquesmentioning

confidence: 99%

Sulfonate‐Functionalized AIEgens: Strategic Approaches Beyond Water Solubility for Sensing and Imaging Applications

2022

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“…designed a tetraphenylethylene (TPE) derivative with two sulfonate groups ( Figure ). [ 96 ] The negatively charged AIE probe TPE‐di‐sulfonate showed strong electrostatic interaction with the amino groups of lipoteichoic acid, which restricted the intramolecular motion of TPE‐di‐sulfonate, thus exhibiting 43 folds increase of fluorescent intensity upon incubating with Gram‐positive Staphylococcus aureus or Bacillus subtilis . However, negligible fluorescence was observed upon TPE‐di‐sulfonate was incubated with Gram‐negative E. coli or Pseudomonas aeruginosa .…”

Section: Aiegens For Bacterial Treatmentmentioning

confidence: 99%

“…Reproduced with permission. [ 96 ] Copyright 2018, the Royal Society of Chemistry. B) Chemical structure of TTVP, Confocal images of S. epidermidis , S. aureus , and E. coli incubated with 1 µ m of TTVP for 3 s. Reproduced with permission.…”

Section: Aiegens For Bacterial Treatmentmentioning

confidence: 99%

Aggregation‐Induced Emission‐Based Platforms for the Treatment of Bacteria, Fungi, and Viruses

Chen

Han

Tang

et al. 2021

Adv Healthcare Materials

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The prevention and control of pathogenic bacteria, fungi, and viruses is a herculean task for all the countries since they greatly threaten global public health. Rapid detection and effective elimination of these pathogens is crucial for the treatment of related diseases. It is urgently demanded to develop new diagnostic and therapeutic strategies to combat bacteria, fungi, and viruses‐induced infections. The emergence of aggregation‐induced emission (AIE) luminogens (AIEgens) is a revolutionary breakthrough for the treatment of many diseases, including pathogenic infections. In this review, the main focus is on the applications of AIEgens for theranostic treatment of pathogenic bacteria, fungi, and viruses. Due to the AIE characteristic, AIEgens are promising fluorescent probes for the detection of bacteria, fungi, and viruses with excellent sensitivity and photostability. Moreover, AIEgen‐based theranostic platforms can be fabricated by introducing bactericidal moieties or designing AIE photosensitizers and AIE photothermal agents. The current strategies and ongoing developments of AIEgens for the treatment of pathogenic bacteria, fungi, and viruses will be discussed in detail.

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“…The detection limit is about 10 4 CFU•mL -1 Target recognition of E. coli [35] Sulfonate functionalized TPE The detection limit is 1.19 × 10 6 CFU mL -1 Target recognition of Gram-positive bacteria [86] TTVP The detection limit is 10 . Reproduced with permission.…”

Section: Bacteria Identification and Ablationmentioning

confidence: 99%

AIEgens for Bacterial Imaging and Ablation

Borjihan

Dong

et al. 2021

Adv Healthcare Materials

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Accurate and sensitive diagnosis of pathogenic bacterial infection is a fundamental first step for correct bacteria management, helping to avoid the development of drug-resistant bacteria caused by the inappropriate use and overuse of antibiotics. Fluorescence probes as a promising visual tool can help identify pathogens rapidly and reliably. However, rigidly structured traditional fluorescence probes generally suffer from the drawback of aggregation-caused quenching (ACQ) effect, which greatly undermines their advantages with respect to sensitivity. Luminogens with aggregation-induced emission properties, namely AIEgens, can overcome the ACQ effect and certain AIEgen-based materials are capable of generating reactive oxygen species (ROS) in the aggregate states. Hence, they have become powerful tools for imaging and killing bacteria. This review summarizes the recent advances in AIEgens for the diagnosis and treatment of pathogen infections. Special attention has been paid to the molecular design, the application in bacterial imaging and ablation in vitro and in vivo, and the biocompatibility of AIEgens. Finally, the challenges and prospects are discussed in terms of using AIEgens to advance precision therapies for pathogen infections.

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Sulfonate-functionalized tetraphenylethylenes for selective detection and wash-free imaging of Gram-positive bacteria (Staphylococcus aureus)

Abstract: Two sulfonate functionalized tetraphenylethylene (TPE) derivatives were synthesized and used as probes for the detection and imaging of Gram-positive bacteria (e.g. Staphylococcus aureus).

Cited by 28 publications

References 76 publications

Sulfonate‐Functionalized AIEgens: Strategic Approaches Beyond Water Solubility for Sensing and Imaging Applications

Sulfonate‐Functionalized AIEgens: Strategic Approaches Beyond Water Solubility for Sensing and Imaging Applications

Aggregation‐Induced Emission‐Based Platforms for the Treatment of Bacteria, Fungi, and Viruses

AIEgens for Bacterial Imaging and Ablation

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