Sulfonamides in dermatology

Fuchs, S.; Elsner, Peter

doi:10.1016/s0738-081x(02)00326-7

Cited by 13 publications

(2 citation statements)

References 31 publications

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“…However, this compound also demonstrates a series of undesirable local actions such as cytotoxicity against fibroblasts and keratinocytes [44]. The systemic disorders following the silver sulfadiazine application have also been described [45–47]. Beside the application of SSD in the course of injury management, other novel, promising methods, such as electrotherapy, laser irradiation, and ultrasound therapy, of possible application in wound treatment exist.…”

Section: Discussionmentioning

confidence: 99%

Propolis Modulates Fibronectin Expression in the Matrix of Thermal Injury

Olczyk

Komosińska-Vassev

Wisowski

et al. 2014

BioMed Research International

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The aim of the study was to assess the propolis effect on fibronectin metabolism in the course of burn wounds healing process. A model of burn wound healing of pig skin was applied. The amount of the released glycoprotein was assessed by a surface plasmon resonance. The profile of extracted fibronectin components was also assessed by an electrophoresis in polyacrylamide gel, with a subsequent immunodetection by Western Blotting. Propolis burn treatment decreased the release of fibronectin components from healing wounds in relation to damages treated with silver sulfadiazine. The main reason of decreased extraction of fibronectin components from wounds treated with propolis was a substantial decrease of degradation product release of the mentioned glycoprotein, which was observed particularly from the 3rd to 5th day of the repair. Wounds treatment with propolis demonstrated, especially in relation to damages treated with silver sulfadiazine, the decreased release of synthesized fibronectin molecules. The obtained results suggest that propolis modifies fibronectin metabolism in the course of wound healing process. The influence of propolis is reflected in prevention of fibronectin biosynthesis as well as its degradation in the wound area. The above-mentioned metabolic changes may decrease the risk of complications in the repair wounds process.

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Section: Discussionmentioning

confidence: 99%

Propolis Modulates Fibronectin Expression in the Matrix of Thermal Injury

Olczyk

Komosińska-Vassev

Wisowski

et al. 2014

BioMed Research International

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“…The mechanism of the antimicrobial action of silver sulfadiazine (SSD) is based on the disruption of metabolic pathways essential for bacterial cell division and survival. The SSD-sensitive pathogens are Pseudomonas aeruginosa , Klebsiella species, Enterobacter cloacae , Escherichia coli , Proteus mirabilis , Proteus vulgaris , Pseudomonas fluorescens , Serratia , Citrobacter , Staphylococcus aureus , Staphylococcus epidermis , Cyphylococcus aureus , Cyphylococcus epidermingidis , and Enterobacter; and SSD shows in vitro activity against Herpes virus and Candida albicans [ 1 , 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Biological Activity of Propolis Ointment with the Addition of 1% Nanosilver in the Treatment of Experimentally-Evoked Burn Wounds

2021

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The main objective of this study was to assess the pharmacological efficacy of ointments containing 1% propolis and 1% nanosilver, compared to the conventional treatment of burn wounds. In the evaluation of the results, we used clinical observation of scars, microbiological examinations, pathomorphological examinations, and analysis of free radicals. The analysis of the experiment results concerning the therapeutic effectiveness of the propolis ointment revealed its wide-ranging antibacterial action (against Gram-positive and Gram-negative bacteria). The 1% propolis ointment was found to accelerate neoangiogenesis and epithelialization, have a positive effect on the healing of burn wounds, improve the cosmetic look of scars, and have no side-effects. The analysis of free radicals in burn wounds showed impressive activity of the 1% nanosilver ointment in the reduction of free radicals. No synergism of pharmacological activity of propolis and nanosilver was shown. A comparative evaluation of the acquired research material allows us to provide a favorable opinion on the topical treatment of burn wounds with 1% propolis. The obtained results show that the 1% propolis ointment reduces healing time, offers antimicrobial action, and has a positive effect on the normal process of scar formation.

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Synthesis and interaction of bovine serum albumin with p‐hydroxybenzoic acid derivatives

et al. 2012

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Three novel p-hydroxybenzoic acid derivatives (HSOP, HSOX, HSCP) were synthesized from p-hydroxybenzoic acid and sulfonamides (sulfamonomethoxine sodium, sulfamethoxazole and sulfachloropyridazine sodium) and characterized by elemental analysis, HNMR and MS. Interactions between derivatives and bovine serum albumin (BSA) were studied by fluorescence quenching spectra, UV-vis absorption spectra and time-resolved fluorescence spectra. Based on fluorescence quenching calculation and Förster's non-radioactive energy transfer theory, the values of the binding constants, basic thermodynamic parameters and binding distances were obtained. Experimental results indicated that the three derivatives had a strong ability to quench fluorescence from BSA and that the binding reactions of the derivatives with BSA were a static quenching process. Thermodynamic parameters showed that binding reactions were spontaneous and exothermic and hydrogen bond and van der Waals force were predominant intermolecular forces between the derivatives and BSA. Synchronous fluorescence spectra suggested that HSOX and HSCP had little effect on the microenvironment and conformation of BSA in the binding reactions but the microenvironments around tyrosine residues were disturbed and polarity around tyrosine residues increased in the presence of HSOP.

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Sulfonamides in dermatology

Cited by 13 publications

References 31 publications

Propolis Modulates Fibronectin Expression in the Matrix of Thermal Injury

Propolis Modulates Fibronectin Expression in the Matrix of Thermal Injury

Biological Activity of Propolis Ointment with the Addition of 1% Nanosilver in the Treatment of Experimentally-Evoked Burn Wounds

Synthesis and interaction of bovine serum albumin with p‐hydroxybenzoic acid derivatives

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