Sulfasalazine and pentoxifylline in psoriasis: A possible safe alternative

El‐Mofty, Medhat; El-Darouti, Mohammad Ali; Rasheed, Hoda; Bassiouny, Dalia Ahmed; Abdel‐Halim, Mona R. E.; Zaki, Naglaa Sameh; El-Hanafy, Ghada M.; El-hadidi, Heba H; Abu-Azzam, Omar; El-Ramly, Amany Z.; Fawzy, Marwa M.

doi:10.3109/09546630903460260

Cited by 20 publications

(10 citation statements)

References 28 publications

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“…The kidney is an organ that is highly vulnerable to damage caused by ROS, probably due to the abundance of polyunsaturated fatty acids in the composition of renal lipids (6). Pentoxifylline is a low-cost drug with antitumor necrosis factor α (TNF-α) properties (7). This drug is used in the treatment of many diseases such as cardiovascular disorders, diabetic nephropathy, alcoholic hepatitis, and venous leg ulcer (8).…”

Section: Introductionmentioning

confidence: 99%

Effect of pentoxifylline on kidney damage induced by nitrosamine in male rats

et al. 2019

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Nitrosamines are well-known carcinogenic agents. Humans are exposed to nitrosamines in various ways, the most important of which is the diet. Pentoxifylline is a xanthine derivative, which is used as a drug that inhibits inflammatory factors, reduces blood viscosity, improves peripheral blood flow, and increases oxygenation of tissue. This study was designed to evaluate the effects of pentoxifylline against damage induced by nitrosamine to the kidneys of rats. In this study, 48 male rats were randomly assigned to 8 groups: control normal group and nitrosamine control treated group (40 mg/kg); pentoxifylline groups (25, 50, 100 mg/kg) and nitrosamine + pentoxifylline treated groups (25, 50, 100 mg/kg). Treatments were administered either intraperitoneally (nitrosamine) or orally (pentoxifylline) on a daily basis for 28 days. The normalized kidney weight, glomeruli characteristics, thiobarbituric acid reactive species, antioxidant capacity, kidney function indicators, and serum nitrite oxide levels were investigated. Nitrosamine administration increased kidney malondialdehyde (MDA) level, kidney weight, blood urea nitrogen (BUN), creatinine, and nitrite oxide levels and decreased significantly glomeruli number and tissue ferric reducing/antioxidant power (FRAP) level compared to the control normal group ( P < 0.05). The pentoxifylline and pentoxifylline + nitrosamine treatments reduced BUN, kidney MDA level, creatinine, glomerular diameter, and nitrite oxide levels significantly at all doses and increased the glomeruli number, kidney weight, and tissue FRAP level compared to the nitrosamine control group ( P < 0.05). It seems that pentoxifylline administration improved kidney injury induced by nitrosamine in rats.

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Section: Introductionmentioning

confidence: 99%

Effect of pentoxifylline on kidney damage induced by nitrosamine in male rats

et al. 2019

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“…In a study of 52 patients with generalized lichen planus, the most pruritus relieving effect was seen in the first 3 weeks of treatment 9 . Sulfasalazine resulted in a mean 57.09% reduction in PASI score at 8th week in a small psoriasis trial and was associated with promotion and maintenance of hair growth in 6 patients with alopecia areata after 2‐12 months of use 10,11 . Sulfasalazine, to our knowledge, has never been reported as a therapeutic option in EPD.…”

Section: Discussionmentioning

confidence: 89%

Erosive pustular dermatosis of the leg in a young girl successfully treated with sulfasalazine and 308 nm monochromatic excimer light

Seçkin

Tekin

Güneş

et al. 2020

Photoderm Photoimm Photomed

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“…Pentoxifylline is not only compatible with other drugs used for the management of AS, but it is also postulated to act synergistically to reduce TNF-α levels through independent mechanisms with sulfasalazine. Their effectiveness has been shown in other autoimmune disorders such as pemphigus vulgaris, entero-Behcet's disease, and psoriasis [26][27][28]. This is particularly important in the geographical area where the authors of the current study practice because of the higher prevalence of infectious diseases such as TB and the relatively lower socioeconomic status of the population, both of which make the prescription of anti-TNF agents an even more challenging issue and the search for alternatives a necessary area of research.…”

Section: Discussion ____________________________mentioning

confidence: 99%

Pentoxifylline as a new adjunctive therapy in ankylosing spondylitis: A randomized clinical trial

et al. 2017

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Treatment with tumor necrosis factor alpha inhibitors has been increasingly implicated in the management of autoimmune diseases. In spite of their promising effects, they are commonly associated with side effects. This issue indicates the need for newer drugs with the same efficacy and fewer serious adverse effects. Pentoxifylline is a phosphodiesterase which inhibits TNF secretion and exerts to some degree an anti-inflammatory effect. The purpose of this randomized clinical trial was to evaluate the effect of pentoxifylline as an adjunctive therapy in the management of ankylosing spondylitis. Twenty-five patients suffering from ankylosing spondylitis were randomly assigned to treatment or placebo groups having been matched for age and gender. The treatment group received pentoxifylline (1200 mg daily), and the placebo group received a placebo in addition to the standard treatment of sulfasalazine 2-3 gram daily and indomethacin 50-75 mg per day that were given to all the patients in both groups. Serum levels of TNF-α were measured before and after the study intervention. Serum levels of TNF-α were reduced significantly in both groups with a p-value of < 0.001. However, the reduction was more prominent in the group receiving pentoxifylline than in the placebo group, although this between-group difference was not statistically significant. The results demonstrate the need for further studies on the use of pentoxifylline as a safe adjunctive therapy in controlling disease activity and reducing tumor necrosis factor-alpha levels in patients with ankylosing spondylitis.

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Sulfasalazine and pentoxifylline in psoriasis: A possible safe alternative

Abstract: Although incomparable to methotrexate, combined sulfasalazine and pentoxifylline produced a good response in cases of extensive psoriasis. Multicentre studies are needed to validate these results.

Cited by 20 publications

References 28 publications

Effect of pentoxifylline on kidney damage induced by nitrosamine in male rats

Effect of pentoxifylline on kidney damage induced by nitrosamine in male rats

Erosive pustular dermatosis of the leg in a young girl successfully treated with sulfasalazine and 308 nm monochromatic excimer light

Pentoxifylline as a new adjunctive therapy in ankylosing spondylitis: A randomized clinical trial

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