Sulcus vocalis: evidence for autosomal dominant inheritance

Martins, Regina Helena Garcia; Gonçalves, Tatiana Maria; Neves, das; Fracalossi, Thalita; Tavares, Elaine Lara Mendes; Moretti-Ferreira, Danilo

doi:10.4238/2011.december.19.5

Cited by 13 publications

(8 citation statements)

References 5 publications

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“…No recent studies have confirmed this statement, and to our knowledge no other study has investigated the correlation between SV and origin. Other investigators have shown evidence for autosomal dominant inheritance and probable genetic etiology, which could support the thesis of SV as a congenital disorder [26, 27]. …”

Section: Discussionmentioning

confidence: 79%

Background Factors and Subjective Voice Symptoms in Patients with Acquired Vocal Fold Scarring and Sulcus Vocalis

Malmström¹,

Hertegård²

2017

Folia Phoniatr Logop

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Objective: Vocal fold scarring (VFS) and sulcus vocalis (SV) often result in severe and chronic voice disorders. This study compares subjective voice complaints as rated with the Voice Handicap Index and etiological factors for patients with VFS and SV. Patients and Methods: Data were collected from the medical records at the Department of Otorhinolaryngology, Karolinska University Hospital, for 27 VFS patients and 27 SV patients. Descriptive background factors were compared between the groups and data were compared from the Swedish Voice Handicap Index (Sw-VHI) questionnaires. Results: Previous laryngeal surgery/trauma was significantly more common for the patients with VFS. The SV group had significantly more persistent dysphonia since childhood. It was significantly more common to have a non-Germanic language origin among the SV patients. VFS and SV rated high for the total median Sw-VHI scores. The VFS group’s total Sw-VHI and the three domain scores were significantly higher compared to the SV group. The physical domain showed a significantly higher score when compared to the functional and emotional domains in the SV cohort and when compared to the emotional domain in the VFS cohort. Conclusion: There are significant differences between the VFS group and SV group regarding etiological factors as well as the Sw-VHI. The degree and profile of VHI should be considered when selecting patients and evaluating the result of new treatments for this group of patients.

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Section: Discussionmentioning

confidence: 79%

Background Factors and Subjective Voice Symptoms in Patients with Acquired Vocal Fold Scarring and Sulcus Vocalis

Malmström¹,

Hertegård²

2017

Folia Phoniatr Logop

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“…Numerous studies have noted type II lesions within the same family members and they are commonly believed to be hereditary in origin. [17][18][19][20][21] Further evidence of congenital sulci was noted in excised neonatal larynges. 22 Silva et al examined 56 larynges for evidence of congenital anomalies.…”

Section: Discussionmentioning

confidence: 99%

Polyp within the Center of a Vocal Fold Sulcus: A Proposed Pathophysiologic Construct

Mor¹,

Hernández-Prera²,

Tang³

et al. 2016

International Journal of Head and Neck Surgery

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Objective:We noted unusual cases of vocal fold polyps originating from the center of vocal sulci and propose a possible etiology for the development of these lesions. Materials and methods:Three patients presented to our office with acute onset dysphonia. Intraoperative examination revealed vocal polyps originating from the center of vocal sulci. Lesions were treated with microflap excisions and were sent for histopathologic analysis.Results: Pathology of the excised lesions showed a parakeratotic squamous epithelium with mild inflammation and with dilated vascularity suggesting an acute or subacute process. Patients had voice improvement without recurrence of the vocal-polyp or sulcus following surgical excision. Conclusion:We speculate that the observed lesions result from phonotrauma to congenital sulci and propose that partial prolapse of the epithelium is responsible for the formation of the observed vocal polyps.

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“…Years to come will demonstrate the advances in medical and tissue engineering in developing tools to restore the microanatomy and molecular biology in sulcus vocalis. Important breakthroughs have already been made and new studies are showing promising results [46,[61][62][63][64][65][66][67], however, further research is required until a standard technique to address sulcus vocalis is found, ending the ancient struggle of the vocal fold to freely vibrate.…”

Section: Futurementioning

confidence: 99%

Vocal fold sulci – what are the current options for and outcomes of treatment?

Avellaneda¹,

Allen²

2021

Current Opinion in Otolaryngology &Amp; Head &Amp; Neck Surgery

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Purpose of review Sulcus vocalis is a benign condition of the vocal folds that, according to its severity, can affect the quality of the voice of those who have it. Voice symptoms can range from mild to severe, affecting the quality of life of patients with this condition. Although different surgical and no surgical options have been described, no gold standard treatment has been described. Recent findings New evidence supports congenital, inflammatory, and acquired theories for sulcus vocalis. Also, recent literature demonstrated the role of the epithelium in the pathogenesis, which makes the absence of superficial lamina propria no longer the only accepted hypothesis. Technological developments improved the in-office diagnostics capabilities for this condition, but vocal fold palpation remains the gold standard. Different benign laryngeal conditions are associated with sulcus vocalis and knowing when to treat those is very important. Different treatment options are available for sulcus vocalis, however, results are diverse and no strong recommendations for one over the other can be made. Summary Progress continues to be made in our understanding of sulcus vocalis from diagnosis to treatment. Novel and promising therapeutic strategies have been recently developed for this condition; however, more data and investigations are needed to improve their accuracy and reproducibility.

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Sulcus vocalis: evidence for autosomal dominant inheritance

Cited by 13 publications

References 5 publications

Background Factors and Subjective Voice Symptoms in Patients with Acquired Vocal Fold Scarring and Sulcus Vocalis

Background Factors and Subjective Voice Symptoms in Patients with Acquired Vocal Fold Scarring and Sulcus Vocalis

Polyp within the Center of a Vocal Fold Sulcus: A Proposed Pathophysiologic Construct

Vocal fold sulci – what are the current options for and outcomes of treatment?

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