Suicide risk in Huntington's disease.

Maio, Luigi Di; Squitieri, Ferdinando; Napolitano, Gaetana; Campanella, G; Trofatter, J A; Conneally, P. Michael

doi:10.1136/jmg.30.4.293

Cited by 126 publications

(69 citation statements)

References 8 publications

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“…In addition to motor and cognitive impairments, patients with HD frequently experience psychiatric disturbances, such as anxiety and depression (Di Maio et al, 1993), that severely reduce their daily functioning and quality of life (Hamilton et al, 2003;Wheelock et al, 2003). In the brains of HD mice treated with lithium and VPA together, the activity of GSK-3b and HDACs was consistently decreased, and expression of BDNF and HSP70 was rapidly elevated and sustained .…”

Section: Hdmentioning

confidence: 99%

Therapeutic Potential of Mood Stabilizers Lithium and Valproic Acid: Beyond Bipolar Disorder

et al. 2013

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Section: Hdmentioning

confidence: 99%

Therapeutic Potential of Mood Stabilizers Lithium and Valproic Acid: Beyond Bipolar Disorder

et al. 2013

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“…6 The suicide rate among patients with Huntington disease varies between 3% and 7.3%. 17 The aim of our study was to evaluate echogenicity of the basal ganglia, especially in the brain stem raphe, and to correlate ultrasound findings with psychiatric features in particu lar, but also with neurologic and cognitive features.…”

Section: Introductionmentioning

confidence: 99%

Depression in patients with Huntington disease correlates with alterations of the brain stem raphe depicted by transcranial sonography

Krogias

Strassburger

Eyding

et al. 2011

jpn

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Background: Transcranial sonography (TCS) has become a new diagnostic tool in the evaluation of extrapyramidal disorders. Studies of TCS report alterations of the mesencephalic raphe in patients with depression. The aim of this study was to evaluate TCS findings in patients with Huntington disease in correlation with their neurologic and psychiatric status. Methods: We recruited patients with genetically confirmed Huntington disease. The neurological and psychiatric status of participants was assessed by independent physicians. Echogenicities were investigated according to examination protocol for extrapyramidal disorders using a Siemens Sonoline Elegra system. The sonography examiner was blinded for clinical data. Results: We included 39 patients in our study; 21 patients (53.8%) showed symptoms of depression at the time of evaluation and, of those, 15 (71.4%) had hypoechogenic raphe structures. Thirty patients (76.9%) had a history of depressive episodes, 19 (63.3%) of them with hypoechogenic raphe structures. All 9 patients without a history of depressive episodes showed normal echogenicity of raphe structures (sensitivity 63.3%, specificity 100%). Twelve (70.6%) of the 17 patients with Huntington disease who showed psychiatric disturbances prior to the occurrence of motor symptoms exhibited pathological raphe echogenicity (sensitivity 70.6%, specificity 68.2%). Limitations: Most of the patients were taking antichoreatic medication, which particularly influences neurologic status. Thus, a meaningful interpretation of the correlation between TCS findings and neurologic features was limited. Conclusion: As a novel finding, a relation between mesencephalic raphe echogenicity and depressive state could be identified in patients with Huntington disease. An alteration of the serotonergic brain stem raphe might be involved in the pathogenesis of depression in these patients.

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“…Using the data obtained from the Behavioral Inventory, it was observed that the SG when compared to the CG showed statistically significant differences in internalizing factors (Table 1, Figure 2) and total problems (Table 1; Figure 4), suggesting that the behavioral profile with changes involves not only the individual but also the environment where he is inserted, consequently showing losses in his social relation [11][12][13][14] .…”

Section: Discussionmentioning

confidence: 99%

“…Regarding quality of life, there are reports of suicide justified by depression and physical dependence caused by the impact of symptoms on daily activities 11,12 . Therefore, the DH impairs the mental health of individuals and may be observed suffering and emotional stress among family throughout the course of the disease 13,14 .…”

Section: Discussionmentioning

confidence: 99%

Comportamento, competência social e qualidade de vida na Doença de Huntington

2015

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RESUMO: Objetivo: investigar o comportamento, a competência social e a qualidade de vida de indivíduos com a Doença de Huntington (DH), segundo opinião de seus cuidadores. Métodos: constituíram a casuística 30 participantes, com faixa etária de 33 a 79 anos, subdivididos em dois grupos: 15 do grupo amostral (GA) diagnosticados previamente com Doença de Huntington e 15 participantes do grupo controle (GC), pareados quanto à faixa etária, gênero e classificação socioeconômica. Para avaliação destes sujeitos foram aplicados, em seus cuidadores, o Inventário Comportamental Adult Behavior Checklist e o Questionário de Qualidade de Vida WHOQOL-100. Resultados: na avaliação do comportamento e da competência social, os sujeitos do GA apresentaram diferença estatisticamente significante em relação ao GC, segundo opinião dos seus cuidadores, com escores elevados para fatores internalizantes (ansiedade, depressão, isolamento, queixas somáticas), totais de problemas e outros, como problemas do pensamento, atenção e hiperatividade. No questionário de qualidade de vida, para sujeitos com a DH também se evidenciou diferença estatisticamente significante em relação ao grupo controle, em todos os domínios (físico, psicológico, nível de independência, relações sociais, ambiente e aspectos religiosos) e na maioria dos subitens avaliados. O GA apresentou média baixa de qualidade de vida, enquanto o GC apresentou média alta. Conclusão: sujeitos com DH possuem um perfil comportamental, de competência social e qualidade de vida diferenciado e com mais alterações, em relação ao GC, segundo os cuidadores . A Doença de Huntington parece ser responsável pelo conjunto de alterações comportamentais, de competência social e de qualidade de vida, relatado pelos cuidadores.

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Suicide risk in Huntington's disease.

Cited by 126 publications

References 8 publications

Therapeutic Potential of Mood Stabilizers Lithium and Valproic Acid: Beyond Bipolar Disorder

Therapeutic Potential of Mood Stabilizers Lithium and Valproic Acid: Beyond Bipolar Disorder

Depression in patients with Huntington disease correlates with alterations of the brain stem raphe depicted by transcranial sonography

Comportamento, competência social e qualidade de vida na Doença de Huntington

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