Suicide Gene Delivery System Mediated by Ultrasound-Targeted Microbubble Destruction: A Promising Strategy for Cancer Therapy

Wu, Tong; Huang, Chi Ping; Yao, Yiran; Du, Zhaolin; Liu, Zhijun

doi:10.1089/hum.2022.152

Cited by 3 publications

(2 citation statements)

References 118 publications

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“… 29 UTMD-mediated gene therapy is a promising approach in the field of medicine, with potential utility not only in cardiology and cardiovascular therapies 12 , 15 but also in the treatment of tumors. 30 …”

Section: Discussionmentioning

confidence: 99%

Ultrasound-targeted microbubble technology facilitates SAHH gene delivery to treat diabetic cardiomyopathy by activating AMPK pathway

Guo,

Chen,

et al. 2024

iScience

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Section: Discussionmentioning

confidence: 99%

Ultrasound-targeted microbubble technology facilitates SAHH gene delivery to treat diabetic cardiomyopathy by activating AMPK pathway

Guo,

Chen,

et al. 2024

iScience

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“…The constituent shell materials mainly used in the brain cancer therapy system are phospholipids and phospholipid derivatives. Moreover, a broad range of phospholipids with various hydrophobic chain lengths and electrostatic charges have been utilized [ 53 , 57 , 58 ]. Thus, it facilitates the customization of the system according to the characteristics of the delivered material.…”

Section: Structure and Composition Of Mbsmentioning

confidence: 99%

Microbubble Delivery Platform for Ultrasound-Mediated Therapy in Brain Cancers

2023

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The blood-brain barrier (BBB) is one of the most selective endothelial barriers that protect the brain and maintains homeostasis in neural microenvironments. This barrier restricts the passage of molecules into the brain, except for gaseous or extremely small hydrophobic molecules. Thus, the BBB hinders the delivery of drugs with large molecular weights for the treatment of brain cancers. Various methods have been used to deliver drugs to the brain by circumventing the BBB; however, they have limitations such as drug diversity and low delivery efficiency. To overcome this challenge, microbubbles (MBs)-based drug delivery systems have garnered a lot of interest in recent years. MBs are widely used as contrast agents and are recently being researched as a vehicle for delivering drugs, proteins, and gene complexes. The MBs are 1–10 μm in size and consist of a gas core and an organic shell, which cause physical changes, such as bubble expansion, contraction, vibration, and collapse, in response to ultrasound. The physical changes in the MBs and the resulting energy lead to biological changes in the BBB and cause the drug to penetrate it, thus enhancing the therapeutic effect. Particularly, this review describes a state-of-the-art strategy for fabricating MB-based delivery platforms and their use with ultrasound in brain cancer therapy.

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Delivery of sPD1 gene by anti-CD133 antibody conjugated microbubbles combined with ultrasound for the treatment of cervical cancer in mice

Liu¹,

Zheng²,

Han³

et al. 2023

Toxicology and Applied Pharmacology

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Suicide Gene Delivery System Mediated by Ultrasound-Targeted Microbubble Destruction: A Promising Strategy for Cancer Therapy

Cited by 3 publications

References 118 publications

Ultrasound-targeted microbubble technology facilitates SAHH gene delivery to treat diabetic cardiomyopathy by activating AMPK pathway

Ultrasound-targeted microbubble technology facilitates SAHH gene delivery to treat diabetic cardiomyopathy by activating AMPK pathway

Microbubble Delivery Platform for Ultrasound-Mediated Therapy in Brain Cancers

Delivery of sPD1 gene by anti-CD133 antibody conjugated microbubbles combined with ultrasound for the treatment of cervical cancer in mice

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