Suicide and Attempted Suicide in Tourette’s Syndrome

Dávila, Guadalupe; Berthier, Marcelo L.; Kulisevsky, Jaime; Chacón, Salud Jurado

doi:10.4088/jcp.09l05669blu

Cited by 15 publications

(16 citation statements)

References 13 publications

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“…Prior evidence suggests that individuals with TS have a higher rate of suicidal ideation, which also may apply for a higher rate of suicide. A high rate of suicidal ideations (26.8%) was reported in a consecutive clinical sample of all ages, as well as in a selected sample of adults with malignant TS (35%) .…”

Section: Discussionmentioning

confidence: 99%

Mortality risk in a nationwide cohort of individuals with tic disorders and with tourette syndrome

et al. 2017

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Section: Discussionmentioning

confidence: 99%

Mortality risk in a nationwide cohort of individuals with tic disorders and with tourette syndrome

et al. 2017

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“…Structural and functional neuroimaging and neurophysiological and post-mortem studies have shown that the basal ganglia and related cortico-striato-thalamo-cortical circuits, as well as the dopaminergic neuronal system, may be dysfunctional in TS [5], [6]. Traditional therapies such as pharmacological treatments, behavioral therapies, and surgical approaches can reduce the frequency and intensity of tics but cannot eliminate them entirely.…”

Section: Introductionmentioning

confidence: 99%

Influence of Mesenchymal Stem Cell Transplantation on Stereotypic Behavior and Dopamine Levels in Rats with Tourette Syndrome

Liu

Wang

et al. 2013

PLoS ONE

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ContextTourette syndrome (TS) is a heterogeneous neuropsychiatric disorder. Chronic motor and phonic tics are central symptoms in TS patients. For some patients, tics are intractable to any traditional treatment and cause lifelong impairment and life-threatening symptoms. New therapies should be developed to address symptoms and overt manifestations of TS. Transplantation of neurogenic stem cells might be a viable approach in TS treatment.ObjectiveWe used mesenchymal stem cell (MSC) transplantation to treat TS. We discuss the mechanism of action, as well as the efficiency of this approach, in treating TS.Settings and DesignAn autoimmune TS animal model was adopted in the present study. Forty-eight Wistar rats were randomly allocated to the control group and the 2 experimental groups, namely, TS rats+vehicle and TS rats+MSC. MSCs were co-cultured with 5-bromodeoxyuridine (BrdU) for 24 h for labeling prior to grafting.MethodsStereotypic behaviors were recorded at 1, 7, 14, and 28 days after transplantation. Dopamine (DA) content in the striatum of rats in the 3 groups was measured using a high-performance liquid chromatography column equipped with an electrochemical detector (HPLC-ECD) on day 28 after transplantation.Statistical analysisStatistical analysis was performed by repeated measurements analysis of variance to evaluate stereotypic behavior counts at different time points.ResultsTS rats exhibited higher stereotypic behavioral counts compared with the control group. One week after transplantation, TS rats with MSC grafts exhibited significantly decreased stereotypic behavior. Rats with MSC grafts also showed reduced levels of DA in the striatum when compared with TS rats, which were exposed only to the vehicle.ConclusionsIntrastriatal transplantation of MSCs can provide relief from the stereotypic behavior of TS. Our results indicate that this approach may have potential for developing therapies against TS. The mechanism(s) of the observed effect may be related to the suppression of DA system by decreasing the content of DA in TS rats.

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“…Few studies have focused on SI exclusively on pediatric TD samples, with most studies using a wide age-range (Cheung et al, 2007; Davila et al, 2010; Gharatya et al, 2014). In the only study of SI in children and adolescents with TD to date, around 10% of children had experienced SI over the past year, significantly higher than rates endorsed by community controls (Storch et al, 2015a).…”

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confidence: 99%

“…While there are some strengths to this method, specific continuous measure of SI presence and severity have been developed for youth (Reynolds, 1988) that may allow for a more nuanced examination about not only the clinical features associated with the presence/absence of SI, but the severity of these symptoms as well. Overall, there appears to be a general consensus in the literature that there is a relationship between tic severity, psychiatric comorbidity and SI (Davila et al, 2010). In particular, anxiety and depressive symptoms may increase the risk of SI; however the differential impact of these symptoms has not been fully elucidated.…”

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confidence: 99%

Suicidal ideation in youth with tic disorders

Johnco

McGuire

McBride

et al. 2016

Journal of Affective Disorders

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Background This study examined the incidence and clinical correlates of suicidal ideation (SI) in youth with tic disorders (TD). The independent contribution of tics, anxiety, depressive and externalizing symptoms on SI severity in youth with TD was assessed. Method Participants were 75 treatment-seeking youth with a TD (N = 75) aged 6–18. Participants completed diagnostic assessments, clinician-ratings, self- and parent-report measures of emotional functioning and the presence and/or severity of suicidal ideation. Results Based on youth-report, 61% of youth endorsed at least some symptoms of SI, and 8% endorsed symptoms that exceeded the clinically significant cut-off. Parents reported SI in 11% of cases, with generally poor agreement between parent- and youth-report. Suicidal ideation correlated with higher anxiety, depressive and externalizing symptoms, affective lability, and with poorer distress tolerance and overall functioning. Anxiety, depressive and externalizing symptoms showed an independent relationship with SI. Tic severity was not associated with SI. Rather, higher tic severity was associated with an increase in anxiety symptoms, which in turn, was associated with greater SI severity. Limitations Cross-sectional data limits causal conclusions. Diagnosis was based on unstructured assessments by expert clinicians, including consensus diagnosis, rather than structured clinical interviews. Conclusions Around 8–11% of youth with TD experienced SI. Tic severity did not have any direct influence on SI, however the presence of comorbid anxiety and depressive symptoms significantly increases this risk. Results suggest that it is psychiatric comorbidity, rather than tics themselves, that predispose youth with tic disorders to increased risk of suicidality.

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Suicide and Attempted Suicide in Tourette’s Syndrome

Cited by 15 publications

References 13 publications

Mortality risk in a nationwide cohort of individuals with tic disorders and with tourette syndrome

Mortality risk in a nationwide cohort of individuals with tic disorders and with tourette syndrome

Influence of Mesenchymal Stem Cell Transplantation on Stereotypic Behavior and Dopamine Levels in Rats with Tourette Syndrome

Suicidal ideation in youth with tic disorders

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