Sudden vegetation of the mouth. Pemphigus vegetans of the mouth (Hallopeau type)

Trombelli, Leonardo; Calura, G

doi:10.1001/archderm.128.3.398

Cited by 8 publications

(4 citation statements)

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“…In contrast, other pemphigus variants such as pemphigus foliaceus, pemphigus erythematosus and pemphigus vegetans only rarely affect the oral mucosae (Ahmed et al , 1980; Virgili et al , 1992; Mahe et al , 1996).…”

Section: Pemphigus and Variantsmentioning

confidence: 99%

Number II Pemphigus vulgaris

2005

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Pemphigus is a group of potentially life-threatening autoimmune diseases characterized by cutaneous and/or mucosal blistering. Pemphigus vulgaris (PV), the most common variant, is characterized by circulating IgG antibodies directed against desmoglein 3 (Dsg3), with about half the patients also having Dsg1 autoantibodies. There is a fairly strong genetic background to pemphigus with linkage to HLA class II alleles and ethnic groups such as Ashkenazi Jews and those of Mediterranean and Indian origin, are especially liable. Oral lesions are initially vesiculobullous but readily rupture, new bullae developing as the older ones rupture and ulcerate. Biopsy of perilesional tissue, with histological and immunostaining examination are essential to the diagnosis. Serum autoantibodies to either Dsg1 or Dsg3 are best detected using both normal human skin and monkey oesophagus or by enzyme-linked immunosorbent assay. Before the introduction of corticosteroids, PV was typically fatal mainly from dehydration or secondary systemic infections. Current treatment is largely based on systemic immunosuppression using corticosteroids, with azathioprine or other adjuvants or alternatives but newer therapies with potentially fewer adverse effects, also appear promising.

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Section: Pemphigus and Variantsmentioning

confidence: 99%

Number II Pemphigus vulgaris

2005

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“…In contrast, other types of pemphigus-such as pemphigus foliaceus (PF) and erythematosus and pemphigus vegetans-only rarely affect the oral mucosae (Ahmed et al, 1980;Virgili et al, 1992;Mahé et al, 1996).…”

Section: Other Variantsmentioning

confidence: 99%

“…Oral lesions have been seen in less common pemphigus variants, especially in most cases with IgA pemphigus (intraepithelial IgA pustulosis [IEAP]), and in some cases of pemphigus associated with inflammatory bowel disease (Stone, 1971;Lubach et al, 1984;Delfino et al, 1986;Fabbri et al, 1986;Schwermann et al, 1988;Prendiville et al, 1994). In contrast, other types of pemphigus-such as pemphigus foliaceus (PF) and erythematosus and pemphigus vegetans-only rarely affect the oral mucosae (Ahmed et al, 1980;Virgili et al, 1992;Mahé et al, 1996).…”

Section: Other Variantsmentioning

confidence: 99%

Pemphigus Vulgaris: Update on Etiopathogenesis, Oral Manifestations, and Management

Scully

Challacombe

2002

Critical Reviews in Oral Biology & Medicine

137

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ABSTRACT:Pemphigus is a group of potentially life-threatening diseases characterized by cutaneous and mucosal blistering. There is a fairly strong genetic background to pemphigus with linkage to HLA class II alleles. Certain ethnic groups, such as Ashkenazi Jews and those of Mediterranean origin, are especially liable to pemphigus. Pemphigus vulgaris (PV), the most common and important variant, is an autoimmune blistering disease characterized by circulating pathogenic IgG antibodies against desmoglein 3 (Dsg3), about half the patients also having Dsg1 autoantibodies. Oral lesions are initially vesiculobullous but readily rupture, new bullae developing as the older ones rupture and ulcerate. Biopsy of perilesional tissue, with histological and immunostaining examinations, is essential to the diagnosis. Serum autoantibodies to either Dsg1 or Dsg3 are best detected by both normal human skin and monkey esophagus or by enzyme-linked immunosorbent assay (ELISA). Before the introduction of corticosteroids, pemphigus vulgaris was typically fatal mainly from dehydration or secondary systemic infections. Current treatment is largely based on systemic immunosuppression using systemic corticosteroids, with azathioprine, dapsone, methotrexate, cyclophosphamide, and gold as adjuvants or alternatives, but mycophenolate mofetil and intravenous immunoglobulins also appear promising.

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“…Oral lesions may be the sole manifestation (23) and have also been seen in all reported cases of paraneoplastic pemphigus (6, 23, 32, 75, 104, 1811, in IgA pemphigus (intraepithelial IgA pustulosis (25)) and in some cases of pemphigus associated with inflammatory bowel disease (51, 64,126,180,199). In contrast, other types of pemphigus such as pemphigus foliaceus and erythematosus and pemphigus vegetans only rarely affect the oral mucosae (1, 127, 228,237).…”

Section: Fig 5 Pemphigus Vulgaris Can Present With Desquamative Ginmentioning

confidence: 99%

Mucocutaneous disorders

Scully¹,

Laskaris²

1998

Periodontology 2000

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Sudden vegetation of the mouth. Pemphigus vegetans of the mouth (Hallopeau type)

Cited by 8 publications

References 0 publications

Number II Pemphigus vulgaris

Number II Pemphigus vulgaris

Pemphigus Vulgaris: Update on Etiopathogenesis, Oral Manifestations, and Management

Mucocutaneous disorders

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Sudden vegetation of the mouth. Pemphigus vegetans of the mouth (Hallopeau type)

Cited by 8 publications

References 0 publications

Number II Pemphigus vulgaris

Number II Pemphigus vulgaris

Pemphigus Vulgaris: Update on Etiopathogenesis, Oral Manifestations, and Management

Mucocutaneous disorders

Contact Info

Product

Resources

About

Number II Pemphigus vulgaris

Number II Pemphigus vulgaris