Sudden Cardiac Death in Infants, Children and Young Adults: Possible Roles of Dietary Magnesium Intake and Generation of PlateletActivating Factor in Coronary Arteries

Altura, Burton M.; Li, Wenyan; Zhang, Aimin; Zheng, Tao; Shah, Nilank C; Shah, Gatha J; Altura, Bella T.

doi:10.16966/2379-769x.121

Cited by 8 publications

(2 citation statements)

References 52 publications

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“…The World Health Organization reported that the frequency of Mg deficiency is still problematic in general population in both developed and developing countries (54). A high percentage of pregnant women with low serum ionized Mg levels is found in the USA (55). Thus, pregnant women are still recommended to include good sources of Mg in their diets (56).…”

Section: Magnesiummentioning

confidence: 99%

The Effect and Potential Mechanism of Maternal Micronutrient Intake on Offspring Glucose Metabolism: An Emerging Field

Zhang

Xiao

2021

Front. Nutr.

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Diabetes has become the most common metabolic disease around the world. In addition to genetic and environmental factors in adulthood, the early life environment is critical to the progression of diabetes in adults, especially the environment during the fetal period; this concept is called “fetal programming.” Substantial evidence has illustrated the key role of early life macronutrient in programming metabolic diseases. Recently, the effect of maternal micronutrient intake on offspring glucose metabolism during later life has become an emerging field. This review focuses on updated human and animal evidence about the effect of maternal micronutrient status on offspring glucose metabolism and the underlying mechanism.

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Section: Magnesiummentioning

confidence: 99%

The Effect and Potential Mechanism of Maternal Micronutrient Intake on Offspring Glucose Metabolism: An Emerging Field

Zhang

Xiao

2021

Front. Nutr.

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“…Brazil nut is an important food source of Mg, since it contains 365mg to 393mg/100g of this microelement (39). Mg deficiency has been linked to endothelial dysfunction, arterial stiffening, atherosclerosis, mortality due to coronary heart disease mortality and sudden cardiac death (SCD) (46)(47)(48)(49)(50)(51). Dietary intake of Mg reduced arterial calcification and stiffening and improves arterial flowmediated dilation and decreases carotid IMT (50, 52).…”

Section: Magnesium (Mg)mentioning

confidence: 99%

Anti-atherosclerotic and cardiovascular protective benefits of Brazilian nuts

Ferrari

2020

Front Biosci

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Introduction 3. Epidemiological aspects 4. Atheroprotective effect of constituents of Brazil nuts 4.1. Dietary intake of Brazil nuts and protection against atherosclerosis 4.2. Dietary fiber and atherosclerosis 4.3. The atheroprotective effect of micronutrients of Brazil nuts 4.3.1. Magnesium (Mg) 4.3.2. Selenium (Se) 4.4. Arginine and other amino acids 4.5. Fatty acids, phytosterols, and sphingolipids 4.6. Tocopherols 4.7. Polyphenols 5. Summary and perspectives 6. Acknowledgements 7. References Atheroprotective effects of Brazil nuts 39© 1996-2020 from the neighborhood states, the so-called Legal Amazon, tend to have a lower concentration of this microelement (2,3). The objective of this review is to update the relationship of dietary intake of Brazil nuts and the mechanistic role of their bioactive compounds against atherosclerosis and cardiovascular disease. EPIDEMIOLOGICAL ASPECTSThe two oldest studies regarding nuts, recorded in the MEDLINE, are descriptions of Trapa bispinosa and Anacardium occidentale, respectively published in 1927 and 1930 (4,5). Fraser et al. (6) developed the Adventist Health Study and reported that dietary intake of nuts (5 times per week) was associated with a 48% decrease in the risk of mortality from coronary heart disease (6). Six years later, the Nurses' Health Study found that regular intake of nuts diminished the risk of coronary heart disease (CHD) and non-fatal myocardial infarction (7). The PREDIMED study, a Spanish cohort study covering 7,216 men and women, concluded that frequent consumption of Brazil nut (>3 servings per week) reduced overall, cardiovascular, and cancer mortality (8). In some populations, intake of Brazil nuts is frequent (9). Some studies suggested an association between dietary intake of nuts and decreased risk of other cardiovascular diseases, stroke, and possibly type 2 diabetes mellitus (10-12). ATHEROPROTECTIVE EFFECT OF CONSTITUENTS OF BRAZIL NUTSBrazil nuts are considered very nutritious, since they contain considerable amounts of fiber, macronutrients, micronutrients and bioactive compounds, such as phytosterols, phenolics, and flavonoids (1,13,14). Antioxidant activity Increased expression of nuclear factor E2-related factor (Nrf2) Decrease in reactive oxygen species (ROS) Decrease in reactive nitrogen species Decrease in lipid peroxidation Decrease in DNA peroxidation Decrease in LDL peroxidation Anti-inflammatory activity Decrease in the blood levels of IL-1, IL-6, INF-γ, TNF-α Decrease in vascular inflammation Antidiabetic activity Decrease in blood glucose level Decrease in pancreatic load Anti-atherosclerosis activity Decrease in formation of macrophage foam cells Decrease in atherogenesis Decrease in total amount of cholesterol, triglycerides, and apolipoprotein-A in the blood Improves blood viscosity

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Magnesium Deficiency, Sphingolipids, and Telomerase: Relevance to Atherogenesis, Cardiovascular Diseases, and Aging

Altura

Shah

et al. 2018

Handbook of Famine, Starvation, and Nutrient Deprivation

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Sudden Cardiac Death in Infants, Children and Young Adults: Possible Roles of Dietary Magnesium Intake and Generation of PlateletActivating Factor in Coronary Arteries

Cited by 8 publications

References 52 publications

The Effect and Potential Mechanism of Maternal Micronutrient Intake on Offspring Glucose Metabolism: An Emerging Field

The Effect and Potential Mechanism of Maternal Micronutrient Intake on Offspring Glucose Metabolism: An Emerging Field

Anti-atherosclerotic and cardiovascular protective benefits of Brazilian nuts

Magnesium Deficiency, Sphingolipids, and Telomerase: Relevance to Atherogenesis, Cardiovascular Diseases, and Aging

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