Sucrose esters improve the colloidal stability of nanoethosomal suspensions of (−)‐epigallocatechin gallate for enhancing the effectiveness against UVB‐induced skin damage

Abstract

Nanoethosomal suspensions, composed of phospholipids, ethanol, and water, are novel lipid carriers. These suspensions have been reported to enhance the permeation of drugs into the skin as a result of the interdigitation effect of ethanol on the lipid bilayer of liposomes and by increasing the fluidity of lipids in the stratum corneum. The physical stability of the nanoethosomal suspension is still a critical research problem until now. This study investigated the commercial palm sucrose esters to improve the colloidal stability of nanoethosomal suspensions. The results indicated that palm sucrose esters (PSE) were effective for stabilizing nanoethosomal suspension of (-)-epigallocatechin gallate (EGCG) from green tea. A PSE concentration of 0.15% was optimal for a nanoethosomal suspension which gave mean diameter 75.5 ± 3.5 nm, zeta potential -30.8 ± 3.2 mV and polydispersity index 0.207 ± 0.017. Moreover, the effectiveness of stabilization was influenced by the degree of esterification of the sucrose esters: the sucrose polyesters could prolong the stability of nanoethosomes loaded with EGCG to a year, but the sucrose monoesters only provided less than 6 months of stabilization. EGCG nanoethosomal suspension stabilized by sucrose polyesters shows better inhibition effectiveness against UVB-induced skin damage than native EGCG. The nanoethosomal suspension has the potential for its utilization as skin care and other products. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 2416-2425, 2017.

Activity of catechins and their applications

“…BP-4, a soluble UVB filter, can stabilise EGCG to produce effective anti-oxidants. Catechin preparations made with lipid ingredients are less stable in heat, so it is necessary to Gallego et al 2017, Spizzirri et al 2009, Nadim et al 2014, Feng et al 2014, Feng et al 2013, Zhong and Shahidi 2011, Muhammad et al 2014, Li and Seeram 2018, Choi et al 2018, Shoko et al 2018, Lima et al 2016 UV protection Improve the stability of catechins in sunlight and increase the UV protection effect Zhang et al 2016, Yoshino et al 2013, Niu et al 2017, Huang et al 2007, Martincigh and Ollengo 2016, Parisi et al 2012, Kim et al 2012, Xia et al 2005 Anti-microbial activities Demonstrates anti-microbial activity and develops pharmaceuticals and functional cosmetics de Oliveira et al 2017, Aoshima et al 2009, Goyal et al 2017 Anti-allergenic and antiinflammatory activities…”

“…Studies have also been conducted to find effective uses for catechins in various fields, such as the prevention of skin ageing, by increasing their efficacy and stability. Catechins improve the stability of EGCG nanoethosomal suspensions to enhance the effectiveness of inhibiting UVB-induced skin damage (Zhang et al 2016). Emulsification of catechins increases the permeation of the skin, protective capacity against UV rays, and anti-ageing effects (Yoshino et al 2013).…”

Controlled released naringin-loaded liposome/sucrose acetate isobutyrate hybrid depot for osteogenesis in vitro and in vivo

“…Obviously, SAIB provided a secondary barrier for drugs attached to the surface of the liposome membrane to be released into the medium. Moreover, Esters of SAIB could enhance liposome membrane stability physically to decrease drug release ( Zhang et al, 2017 ). The values of the diffusion coefficient (n) in the Ritger–Peppas equation were less than .43 for the Ng-lipo/SAIB group, indicating that the mechanism of drug release from the liposomal SAIB-based depots was diffusion ( Cuomo et al, 2015 ).…”

Catechins and Theaflavins: An Overview on Therapeutic Application

“…Catechins have also being studied to see if they may be used in a variety of disciplines, including the protection of aging process of skin, by improving their effectiveness and stability. Catechins boost the stability of EGCG nanoethosomal suspensions, enhancing their capacity to protect skin from UVB damage 42 . Catechins that have been emulsified have increased skin permeability, UV protection, and anti-aging properties 43 .…”