1978
DOI: 10.1001/archderm.114.6.889
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Successful use of cyclophosphamide and prednisone for initial treatment of pemphigus vulgaris

Abstract: Previous reports showed that cyclophosphamide used late in the treatment of patients with pemphigus vulgaris reduced the complications due to steroids. In this study, cyclophosphamide was used in the initial treatment of five patients with pemphigus vulgaris in combination with prednisone to avoid side-effects of prednisone. Two patients had no prior treatment with steroids for pemphigus. Results indicate that initial combined program may be a highly effective treatment method for pemphigus vulgaris. Followup … Show more

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Cited by 27 publications
(17 citation statements)
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“…Early studies reported the corticosteroid‐sparing effects of cyclophosphamide at doses of 50–200 mg per day in case series of up to six patients . Prolonged remission with cessation of all therapy was observed in some cases .…”
Section: Adjuvant Drugsmentioning
confidence: 99%
“…Early studies reported the corticosteroid‐sparing effects of cyclophosphamide at doses of 50–200 mg per day in case series of up to six patients . Prolonged remission with cessation of all therapy was observed in some cases .…”
Section: Adjuvant Drugsmentioning
confidence: 99%
“…12,14,[22][23][24][25][26][27][28][29][30] Azathioprine has been used successfully for nearly 4 decades as an adjuvant in combination with corticosteroids. The active metabolite of azathioprine is mercaptopurine, which is intracellularly converted to 6-thionine acid.…”
Section: Commentmentioning
confidence: 99%
“…Other adverse effects included diabetes mellitus, cardiac complications, alopecia, amenorrhea, and sterility. 42,43 Haemorrhagic cystitis and pituitary adrenal suppression has also been reported.…”
mentioning
confidence: 97%
“…42,43 Cyclophosphamide is a potent alkylating agent with cytostatic properties that cross-links DNA and other macromolecules, such as RNA and proteins, causing failure of cell division. This chemotherapeutic agent was used since it would act upon both B cells and T cells and suppress autoantibody production.…”
mentioning
confidence: 99%