Successful Treatment of Phantosmia With Preservation of Olfaction

Distorted Odorant Perception

“…The peripheral theory is based on the inability of abnormal olfactory neurons to form a complete picture of the odorant. 2,12 This hypothesis is in agreement with our findings that all individuals with parosmia have an intensity loss along with parosmia. Recently, Leopold et al 13 described a series of 8 patients surgically treated for phantosmia.…”

Long-term Follow-up of Surgically Treated Phantosmia

“…These first 2 features were also noted in our previous report on phantosmia. 4 The last feature has not been described previously. Much of the cross-sectional area of large fascicles of the olfactory nerve lacked axons as evidenced by an absence of immunostaining with anti-NT and anti-OMP.…”

Phantosmia May Predict Long‐Term Measurable Olfactory Dysfunction After COVID ‐19

“…19 This symptom has also been associated with histopathological changes in the olfactory epithelium. 48,49 These results should be carefully interpreted, given that the presence of persistent qualitative smell symptoms may represent an ongoing regeneration process. This observation suggests the need for longer follow-up studies, as more time is required to attribute a prognostic role for parosmia or phantosmia in the outcome of the final smell function.…”

“…Phantosmia has been recently described in COVID‐19 patients, 18 with a variable reported prevalence, ranging from 11.8% at 6 months of follow‐up 16 to 20.5% between 100 and 244 days following COVID‐19 19 . This symptom has also been associated with histopathological changes in the olfactory epithelium 48,49 . These results should be carefully interpreted, given that the presence of persistent qualitative smell symptoms may represent an ongoing regeneration process.…”