Successful Treatment of Necrobiosis Lipoidica Diabeticorum With Photodynamic Therapy

Heidenheim, Michael; Jemec, Gregor B. E.

doi:10.1001/archderm.142.12.1548

Cited by 39 publications

(14 citation statements)

References 11 publications

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“…PDT has been shown to elicit immunomodulatory effects that eventually may lead to tumor destruction. These effects include the modification of cytokine expression, induction of immune-specific responses, production of interleukin 1β, interleukin 2, granulocyte colony-stimulating factor and tumor necrosis factor α [10, 11]. Kim et al [12] have used PDT to successfully cure granuloma annulare, a granulomatous disease with certain similarities to NL.…”

Section: Discussionmentioning

confidence: 99%

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Photodynamic Therapy of Necrobiosis Lipoidica – A Multicenter Study of 18 Patients

et al. 2008

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Background: Necrobiosis lipoidica (NL) is a granulomatous skin disease of unknown origin, and no reliably effective treatment option exists to handle this often disfiguring disease. Recently, a patient with long-lasting NL was reported to be cured by topical photodynamic therapy (PDT). Objective: To evaluate the overall potential of PDT in the treatment of NL on the lower legs. Methods: Retrospective study of 18 patients (aged 16–62 years) from 3 European university departments of dermatology treated with PDT for NL. Methyl aminolevulinate or 5-aminolevulinic acid were used as topically applied photosensitizers. Illumination followed with red light-emitting diode light. Results:Complete response was seen in 1/18 patients after 9 PDT cycles, and partial response in 6/18 patients (2–14 PDT cycles) giving an overall response rate of 39% (7/18). Conclusion: Although almost 40% of the cases showed some degree of response, PDT cannot currently be recommended as first-line therapy of NL. Subpopulations of therapy-resistant NL patients may, however, benefit from PDT.

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Section: Discussionmentioning

confidence: 99%

“…In 2006, Heidenheim and Jemec [10] successfully treated a diabetic patient with a 10-year history of NL by topical photodynamic therapy (PDT). They observed a complete remission of the NL lesion after 6 cycles of PDT using methyl aminolevulinate (MAL, 160 mg/g) and red light.…”

Section: Introductionmentioning

confidence: 99%

Photodynamic Therapy of Necrobiosis Lipoidica – A Multicenter Study of 18 Patients

et al. 2008

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“…This therapy, as recently reported, has also proved successful in treating necrobiosis lipoidica diabeticorum (5).…”

mentioning

confidence: 53%

Successful topical photodynamic treatment of refractory necrobiosis lipoidica

Giorgi

Buggiani

Rossi

et al. 2008

Photoderm Photoimm Photomed

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“…Interaction of PpIX with a visible light source of an appropriate wavelength results in the production of singlet oxygen and reactive oxygen species, which causes cellular apoptosis and necrosis. Recent reports indicating the efficacy of PDT in various inflammatory and granulomatous skin disorders, such as chronic palmoplantar eczema, necrobiosis lipoidica diabeticorum and granuloma annulare, urged us to treat our patient with this modality . After a single session of PDT, we achieved relief of symptoms and resolution of the lesions.…”

Section: Discussionmentioning

confidence: 93%

Acquired perforating dermatosis successfully treated with photodynamic therapy

Sezer

Erkek

2011

Photoderm Photoimm Photomed

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Acquired perforating dermatosis is a rare perforating skin disorder characterized by intensely pruritic papules or nodules with central adherent plugs mainly observed on the lower extremities and transepidermal elimination of collagen bundles. Treatment of acquired perforating dermatosis is a matter of debate and conventional treatment options including topical and systemic retinoids, topical corticosteroids and keratolytics, ultraviolet B phototherapy, psoralen plus ultraviolet A (PUVA), allopurinol and cryosurgery show mixed results. Herein, we describe a 60-year-old woman with a diagnosis of acquired perforating dermatosis secondary to diabetes mellitus in whom we achieved excellent results with photodynamic treatment. As far as we are aware, this is the first case report of photodynamic treatment for acquired perforating dermatosis.

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Successful Treatment of Necrobiosis Lipoidica Diabeticorum With Photodynamic Therapy

Cited by 39 publications

References 11 publications

Photodynamic Therapy of Necrobiosis Lipoidica – A Multicenter Study of 18 Patients

Photodynamic Therapy of Necrobiosis Lipoidica – A Multicenter Study of 18 Patients

Successful topical photodynamic treatment of refractory necrobiosis lipoidica

Acquired perforating dermatosis successfully treated with photodynamic therapy

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