Successful treatment of idiopathic hypersomnia and narcolepsy with modafinil

Subjective effects of modafinil, a new central adrenergic stimulant in healthy volunteers: a comparison with amphetamine, caffeine and placebo

“…Side effects we noticed with amphetamine are already known. The incidence of headache observed in this sample under modafinil is higher than in the placebo condition, which is not in accordance with clinical data (Phase I studies, Bastuji and Jouvet, 1988). We have no definite explanation, except that the collection of side effects might differ from one study to another.…”

Subjective effects of modafinil, a new central adrenergic stimulant in healthy volunteers: a comparison with amphetamine, caffeine and placebo

“…Side effects we noticed with amphetamine are already known. The incidence of headache observed in this sample under modafinil is higher than in the placebo condition, which is not in accordance with clinical data (Phase I studies, Bastuji and Jouvet, 1988). We have no definite explanation, except that the collection of side effects might differ from one study to another.…”

Modafinil in the treatment of idiopathic hypersomnia without long sleep time—a randomized, double‐blind, placebo‐controlled study

“…(). The subjective ratings in CGI confirmed the significant effect of modafinil already found in older controlled trials (Bastuji and Jouvet, ; Billiard, ).…”

“…The difference of gender effect of modafinil and placebo on ESS in V2 and V5 may be caused by the pharmacogenetic difference described in patients with narcolepsy by Dauvilliers et al (2002). The subjective ratings in CGI confirmed the significant effect of modafinil already found in older controlled trials (Bastuji and Jouvet, 1988;Billiard, 1996).…”

Adrafinil: A Novel Vigilance Promoting Agent

“…In canine narcolepsy, modafinil increases wakefulness and reduces slow-wave sleep but is unable to suppress cataplexy (50). This finding has also been seen in humans with narcolepsy (2,5,6).…”

Subjective effects of modafinil, a new central adrenergic stimulant in healthy volunteers: a comparison with amphetamine, caffeine and placebo

“…Side effects we noticed with amphetamine are already known. The incidence of headache observed in this sample under modafinil is higher than in the placebo condition, which is not in accordance with clinical data (Phase I studies, Bastuji and Jouvet, 1988). We have no definite explanation, except that the collection of side effects might differ from one study to another.…”

Modafinil in the treatment of idiopathic hypersomnia without long sleep time—a randomized, double‐blind, placebo‐controlled study

“…(). The subjective ratings in CGI confirmed the significant effect of modafinil already found in older controlled trials (Bastuji and Jouvet, ; Billiard, ).…”

“…The difference of gender effect of modafinil and placebo on ESS in V2 and V5 may be caused by the pharmacogenetic difference described in patients with narcolepsy by Dauvilliers et al (2002). The subjective ratings in CGI confirmed the significant effect of modafinil already found in older controlled trials (Bastuji and Jouvet, 1988;Billiard, 1996).…”

Adrafinil: A Novel Vigilance Promoting Agent

“…In canine narcolepsy, modafinil increases wakefulness and reduces slow-wave sleep but is unable to suppress cataplexy (50). This finding has also been seen in humans with narcolepsy (2,5,6).…”

Subjective effects of modafinil, a new central adrenergic stimulant in healthy volunteers: a comparison with amphetamine, caffeine and placebo

“…Side effects we noticed with amphetamine are already known. The incidence of headache observed in this sample under modafinil is higher than in the placebo condition, which is not in accordance with clinical data (Phase I studies, Bastuji and Jouvet, 1988). We have no definite explanation, except that the collection of side effects might differ from one study to another.…”

Modafinil in the treatment of idiopathic hypersomnia without long sleep time—a randomized, double‐blind, placebo‐controlled study

“…(). The subjective ratings in CGI confirmed the significant effect of modafinil already found in older controlled trials (Bastuji and Jouvet, ; Billiard, ).…”

“…The difference of gender effect of modafinil and placebo on ESS in V2 and V5 may be caused by the pharmacogenetic difference described in patients with narcolepsy by Dauvilliers et al (2002). The subjective ratings in CGI confirmed the significant effect of modafinil already found in older controlled trials (Bastuji and Jouvet, 1988;Billiard, 1996).…”

Adrafinil: A Novel Vigilance Promoting Agent

“…In canine narcolepsy, modafinil increases wakefulness and reduces slow-wave sleep but is unable to suppress cataplexy (50). This finding has also been seen in humans with narcolepsy (2,5,6).…”