Successful Treatment of Flat Warts Using Intralesional Candida Antigen

Ritter, Steven E.

doi:10.1001/archderm.139.4.541-c

Cited by 6 publications

(3 citation statements)

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“…The difference in the response rate may be attributed to differences in the number of the studied patients (40 vs 20, respectively), in the number of warts (multiple vs single and multiple, respectively), in the quantity injected (0.1 mL vs 0.3 mL, respectively) and in the number of sessions (5 vs 4, respectively). Ritter and Meffert 14 have also reported, in a case report, complete resolution of recalcitrant plane warts following two doses with 0.3 mL of Candida antigen injected 3 weeks apart.…”

Section: Discussionmentioning

confidence: 86%

“…Intralesional immunotherapy is a promising safe and effective and therapeutic option for common and plantar warts with many reported studies in the literature 6,9,11‐13 . On the other hand, intralesional antigen immunotherapy (with Candida antigen) has been only used in two studies designed originally for the treatment of plane warts 14,15 . In this controlled study, we evaluate the efficacy and safety of intralesional immunotherapy by three different antigens (PPD, Candida antigen, and MMR) for the treatment of plane warts.…”

Section: Discussionmentioning

confidence: 99%

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Intralesional antigen immunotherapy for the treatment of plane warts: A comparative study

Fawzy

Nofal

Alakad

2020

Dermatologic Therapy

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Intralesional immunotherapy by different antigens has shown promising efficacy and safety in the treatment of warts. However, the use of these antigens for the treatment of plane warts has been investigated in two studies only. To evaluate the efficacy and safety of three antigens; Measles Mumps, Rubella vaccine (MMR), Candida antigen, and purified protein derivative (PPD) in the treatment of multiple plane warts. The study included 120 patients who were randomly assigned to three groups, 40 patients in each group. Each agent was injected intralesionally at a dose of 0.1 mL into the largest wart at 2-week intervals until complete clearance or for a maximum of five sessions. Complete clearance of warts was observed in 55% of the PPD group, in 70% of the Candida antigen group, and in 62.5% of the MMR group. No statistically significant difference in the therapeutic response was found between the three groups. Intralesional antigen immunotherapy seems to be a promising well-tolerated and effective therapeutic option for the treatment of multiple plane warts, with relatively higher efficacy of Candida antigen.

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Intralesional antigen immunotherapy for the treatment of plane warts: A comparative study

Fawzy

Nofal

Alakad

2020

Dermatologic Therapy

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“…Other studies have also shown efficacy of candida antigen, but it was used in combination with other antigens such as mumps or trichophyton rather than as monotherapy (5–7). In addition, there is one case report of recalcitrant facial flat warts in a 13‐year‐old female resolving with intralesional candida antigen therapy (8). There is one report in the literature of a painful, edematous, purple distal fingertip developing within 24 hours of intralesional candida antigen injection for a wart on the distal subungual region of the left index finger (9).…”

Section: Discussionmentioning

confidence: 99%

One‐Year Experience with Candida Antigen Immunotherapy for Warts and Molluscum

Maronn

Salm

Lyon

et al. 2008

Pediatric Dermatology

100

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Molluscum contagiosum and warts are two very common viral-induced diseases of childhood. We report our 1-year experience with intralesional candida antigen therapy for both warts and molluscum contagiosum. A retrospective chart review was performed and a total of 217 patients were identified. Follow-up was obtained either through clinic visits or telephone interviews for 25/47 molluscum patients and 55/170 wart patients. Of the molluscum patients with follow-up, 14/25 (56%) had complete resolution, 7/25 (28%) had partial clearing, and 4/25 (16%) had no improvement. For the wart patients with follow-up, 48/55 (87%) had complete resolution, 3/55 (6%) had partial clearing, and 4/55 (7%) had no improvement. It is important to note that our clearance rate may be overestimated, as many patients were also treated concurrently with liquid nitrogen or other therapies. All wart and molluscum patients experienced some discomfort at the time of injection, but no serious side effects were reported. Our experience suggests intralesional candida antigen may represent a treatment option for warts and molluscum contagiosum that is safe and effective.

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Verruca Plana (Flat Viral Warts)

Strumìa

2016

Dermatological Cryosurgery and Cryotherapy

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Successful Treatment of Flat Warts Using Intralesional Candida Antigen

Cited by 6 publications

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Intralesional antigen immunotherapy for the treatment of plane warts: A comparative study

Intralesional antigen immunotherapy for the treatment of plane warts: A comparative study

One‐Year Experience with Candida Antigen Immunotherapy for Warts and Molluscum

Verruca Plana (Flat Viral Warts)

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