2004
DOI: 10.1001/archderm.140.7.794
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Successful Treatment of Epidermolysis Bullosa Pruriginosa With Topical Tacrolimus

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Cited by 49 publications
(39 citation statements)
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References 19 publications
(19 reference statements)
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“…[2] The face and flexures are always spared, and nail dystrophy, albopapuloid lesions, blisters and milia are other common but variable features. [4] Age of onset of skin lesions in EBP is very variable; development of the first clinical sign in adulthood is not uncommon although the reason for the delayed presentation is not known. Lesions may develop at birth.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…[2] The face and flexures are always spared, and nail dystrophy, albopapuloid lesions, blisters and milia are other common but variable features. [4] Age of onset of skin lesions in EBP is very variable; development of the first clinical sign in adulthood is not uncommon although the reason for the delayed presentation is not known. Lesions may develop at birth.…”
Section: Discussionmentioning
confidence: 99%
“…Clinical management of EBP is often difficult and treatment is usually unsatisfactory and includes general measures for pruritus like anti-histaminics and topical steroid with or without occlusion. [8] Trials of a few interventions which have been found to have a variable response in EBP are topical tacrolimus, [4] systemic ciclosporin, [9] Dapsone, [10] thalidomide, [7] and cryotherapy. [5] …”
Section: Discussionmentioning
confidence: 99%
“…Nevertheless, some reports of helpful interventions in EBP have been published. These include topical treatments (eg, tacrolimus), 14 systemic agents (eg, ciclosporin 17 or thalidomide 13 ), and cryotherapy. 12 In summary, we have investigated a family with EBP in whom we have identified a COL7A1 mutation in affected individuals as well as two clinically unaffected family members who may be at risk from developing EBP in the future.…”
Section: Discussionmentioning
confidence: 99%
“…Since the initial publication, a number of other cases of EBP have been reported, collectively highlighting the distinctive nature and clinical spectrum of this form of DEB. [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] Inheritance of EBP may be dominant or recessive, but the cause of the pruritus is uncertain-it is not caused by a specific type of COL7A1 mutation. Other factors, such as atopy or iron deficiency, have been implicated, but no universal abnormality has been found to link all cases of EBP.…”
mentioning
confidence: 99%
“…For example, a patient with epidermolysis bullosa pruriginosa was treated with tacrolimus 0.03% for otherwise intractable itching on the legs and experienced a relief within one week (Banky et al 2004). Patients with chronic irritative hand dermatitis experienced significant reduction of itch during topical treatment with pimecrolimus 1% (Cherill et al 2000).…”
Section: Discussionmentioning
confidence: 99%