Successful treatment of angiosarcoma of the scalp by intralesional cytokine therapy and surface irradiation*

Ulrich, Jens; Krause, Markus; Brachmann, Adna; Franke, Ingolf; Gollnick, Harald

doi:10.1046/j.1468-3083.2000.00111.x

Cited by 26 publications

(13 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[10] Other modalities such as cytokine therapy have been reported in the form of intralesional interferon alpha-2b and interleukin-2 combined with surface radiotherapy, as an alternative to surgery. [13] The role of conventional chemotherapy is debatable since angiosarcoma is a rare disease for which there is no established chemotherapy. However, use of liposomal doxorubicin with radiotherapy, in a wide lesion, has been reported.…”

Section: Discussionmentioning

confidence: 99%

Angiosarcoma of the scalp

Gupta¹,

Chakrabarti²,

Agrawal³

et al. 2009

Indian J Plast Surg

View full text Add to dashboard Cite

Angiosarcoma is a relatively rare soft tissue tumour. It usually occurs in the head and neck, and especially in the scalp, in elderly people. Its presentation varies from a small plaque to multifocal nodules. The treatment depends on the extent of the disease. Most cases are treated with wide excision with reconstruction. Radiotherapy and chemotherapy are advocated in the recurrent or extensive lesions with regional or distant metastasis. Other modalities such as immunomodulation have been tried. A case of a 55-year-old female patient with a bleeding scalp lesion is presented. Initially thought to be a pyogenic granuloma, on excisional biopsy it was diagnosed as angiosarcoma with microscopic involvement of the margins. Wide excision with reconstruction using a local rotation flap was done at a second stage. The patient was not given postoperative radiotherapy or chemotherapy. There has been no recurrence for two years.

show abstract

Section: Discussionmentioning

confidence: 99%

Angiosarcoma of the scalp

Gupta¹,

Chakrabarti²,

Agrawal³

et al. 2009

Indian J Plast Surg

View full text Add to dashboard Cite

show abstract

“…In medicine, surgical resection and radiotherapy for HSA has been reported to result in long-term survival in many cases [3,4]. On the other hand, no standard chemotherapy for HSA has been established; nevertheless, several approaches in chemotherapy have been attempted, such as liposomal doxorubicin, interleukin-2, and interferon-α [63-65]. In recent years, anti-angiogenic therapy has attracted considerable attention as a possible therapy for HSA [66-68].…”

Section: Discussionmentioning

confidence: 99%

Establishment of canine hemangiosarcoma xenograft models expressing endothelial growth factors, their receptors, and angiogenesis-associated homeobox genes

et al. 2009

View full text Add to dashboard Cite

BackgroundHuman hemangiosarcoma (HSA) tends to have a poor prognosis; its tumorigenesis has not been elucidated, as there is a dearth of HSA clinical specimens and no experimental model for HSA. However, the incidence of spontaneous HSA is relatively high in canines; therefore, canine HSA has been useful in the study of human HSA. Recently, the production of angiogenic growth factors and their receptors in human and canine HSA has been reported. Moreover, the growth-factor environment of HSA is very similar to that of pathophysiological angiogenesis, which some homeobox genes regulate in the transcription of angiogenic molecules. In the present study, we established 6 xenograft canine HSA tumors and detected the expression of growth factors, their receptors, and angiogenic homeobox genes.MethodsSix primary canine HSAs were xenografted to nude mice subcutaneously and serially transplanted. Subsequently, the expressions of vascular endothelial growth factor (VEGF)-A, basic fibroblast growth factors (bFGF), flt-1 and flk-1 (receptors of VEGF-A), FGFR-1, and angiogenic homeobox genes HoxA9, HoxB3, HoxB7, HoxD3, Pbx1, and Meis1 were investigated in original and xenograft tumors by histopathology, immunostaining, and reverse transcription polymerase chain reaction (RT-PCR), using canine-specific primer sets.ResultsHistopathologically, xenograft tumors comprised a proliferation of neoplastic cells that were varied in shape, from spindle-shaped and polygonal to ovoid; some vascular-like structures and vascular clefts of channels were observed, similar to those in the original tumors. The expression of endothelial markers (CD31 and vWF) was detected in xenograft tumors by immunohistochemistry and RT-PCR. Moreover, the expression of VEGF-A, bFGF, flt-1, flk-1, FGFR-1, HoxA9, HoxB3, HoxB7, HoxD3, Pbx1, and Meis1 was detected in xenograft tumors. Interestingly, expressions of bFGF tended to be higher in 3 of the xenograft HSA tumors than in the other tumors.ConclusionWe established 6 xenograft canine HSA tumors in nude mice and found that the expressions of angiogenic growth factors and their receptors in xenograft HSAs were similar to those in spontaneous HSA. Furthermore, we detected the expression of angiogenic homeobox genes; therefore, xenograft models may be useful in analyzing malignant growth in HSA.

show abstract

“…Single-case reports repeatedly describe complete durable responses with radiotherapy either alone (19,20) or together with chemo/biotherapeutic agents (21)(22)(23), but the true incidence of such an outcome remains unknown, and it is probably lower than case reports suggest. In a study by Mark et al (24), only one of nine patients (11%) with gross disease treated with radiotherapy with or without chemotherapy was determined to be free of disease.…”

Section: Discussionmentioning

confidence: 99%