Successful Treatment of a Widespread Inflammatory Verrucous Epidermal Nevus With Etanercept

Bogle, Melissa A.; Sobell, Jeffrey M.; Dover, Jeffrey S.

doi:10.1001/archderm.142.3.401

Cited by 12 publications

(6 citation statements)

References 3 publications

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“…In light of the similarities between ILVEN and psoriasis, she was then treated with etanercept. Pruritus resolved after treatment, and the erythema improved over the 6-month follow-up period [85].…”

Section: -Inflammatory Linear Verrucous Epidermal Nevus (Ilven)mentioning

confidence: 89%

Off-Label Dermatological Uses of Etanercept Treatment

2016

J turk acad dermatol

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Background: Tumor necrosis factor-alpha (TNF-α) is a proinflammatory cytokine that plays an immunomodulatory role in a variety of systemic and dermatologic disease. Its blockade can be achieved by using specific inhibitors like etanercept. At present, etanercept is approved for rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, juvenile idiopathic arthritis and psoriasis treatment. However, it has been used with promising results in other inflammatory dermatoses. Etanercept treatment have been reported in the following dermatologic diseases: sarcoidosis, hidradenitis suppurativa, acne vulgaris, cicatricial pemphigoid, pemphigus vulgaris, Hailey-Hailey disease, Behçet' s disease, oral aphthous stomatitis, pyoderma gangrenosum, multicentric reticulohistiocytosis, apthous stomatitis, Sneddon-Wilkinson disease, acrodermatitis continua of Hallopeau, SAPHO syndrome, pityriasis rubra pilaris, vitiligo, necrobiosis lipoidica, silicone granulomas, Sweet's syndrome, atopic dermatitis, dyshidrotic eczema, toxic epidermal necrolysis, alopecia areata, centrifugal annular erythema, primary amyloidosis, erythroderma-related pruritus in Sézary syndrome, cutaneous T-cell lymphoma, inflammatory linear verrucous epidermal nevus, excessive scarring, postherpetic neuralgia, dermatomyositis, vasculitis, lupus erythematosus, and scleroderma. The vast majority of these reports are in the form of individual case reports and small case series. A growing number of published reports suggest that etanercept treatment may be effective in the treatment of numerous inflammatory skin disease outside their currently approved indications.

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Section: -Inflammatory Linear Verrucous Epidermal Nevus (Ilven)mentioning

confidence: 89%

Off-Label Dermatological Uses of Etanercept Treatment

2016

J turk acad dermatol

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“…Reported treatments for ILVEN include topical steroids, 4 topical tretinoin and 5‐fluorouracil, 5 topical calcipotriene, 6,7 pulsed dye laser, 8 CO2 laser, 9 excimer laser, 4 surgical excision, 10,11 TNF‐ inhibitors 12 and IL‐17a inhibitors 13 . Many of these treatments are derived from the psoriasis literature as some believe that the two entities share a common pathogenesis 14,15 …”

Section: Discussionmentioning

confidence: 99%

A case of inflammatory linear verrucous epidermal nevus successfully treated with Brodalumab

Green

Hunter

Chia

2022

Pediatric Dermatology

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Inflammatory linear verrucous epidermal nevus (ILVEN) is a rare type of epidermal nevus, commonly arising in childhood. We present a case of a 13‐year‐old female with Blaschkoid psoriasiform plaques extending from her left foot to the scalp, sparing the right side of the body. While treatment options historically show variable success, we trialed an IL‐17a receptor inhibitor as studies have shown increased levels of IL‐17 receptor expression in ILVEN keratinocytes. At both 3 and 6 months after treatment initiation there was found to be significant improvement. We propose brodalumab as an effective treatment option for widespread ILVEN.

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“…[ 7 ] There are few reports of effective systemic treatments with acitretin and etanercept. [ 8 9 ] Laser ablation, electrofulguration, cryotherapy, and medium to full-depth chemical peels are other alternatives for smaller lesions. Earlier reports say, surgical excision tends to be followed by rapid recurrence unless a generous depth of underlying dermis is removed.…”

Section: Discussionmentioning

confidence: 99%

Giant inflammatory linear verrucous epidermal nevus: Successfully treated with full thickness excision and skin grafting

et al. 2013

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Inflammatory linear verrucous epidermal nevus (ILVEN) is a pruritic, erythematous scaly epidermal nevus which follows a Blaschko's lines. Lichen striatus, linear Darier disease, linear porokeratosis, linear lichen planus, linear psoriasis, and the verrucous stage of incontinentia pigmenti may all have similar clinical presentations as the linear verrucous epidermal nevus. ILVEN can be distinguished from true nevoid psoriasis by pruritus and lack of response to antipsoriatic treatments. Various therapeutic modalities have been described, but no one therapy has been successful consistently. Though giant ILVEN is a relative contraindication to surgical excision, here we report a case showing effectiveness of full thickness excision and skin grafting for this condition.

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Successful Treatment of a Widespread Inflammatory Verrucous Epidermal Nevus With Etanercept

Cited by 12 publications

References 3 publications

Off-Label Dermatological Uses of Etanercept Treatment

Off-Label Dermatological Uses of Etanercept Treatment

A case of inflammatory linear verrucous epidermal nevus successfully treated with Brodalumab

Giant inflammatory linear verrucous epidermal nevus: Successfully treated with full thickness excision and skin grafting

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