Successful switch to ofatumumab after liver injury associated with ocrelizumab treatment in multiple sclerosis: a case report
Alice Mariottini,
Alessandro Barilaro,
Antonio Lotti
et al.
Abstract:Drug-induced liver injury (DILI) is a potential adverse event of disease-modifying therapies (DMTs) for the treatment of multiple sclerosis (MS), as well as of methylprednisolone pulsed therapy used in case of MS relapse. DILI may be induced by different mechanisms, including idiosyncratic reaction, autoimmune hepatitis or viral reactivation. In patients receiving the humanized anti-CD20 monoclonal antibody (mAb) ocrelizumab, DILI has been rarely reported and was mostly associated with hepatitis B virus (HBV) … Show more
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