Successful Plasmapheresis for Fulminant Myasthenia Gravis During Pregnancy

Effects on feto‐placental markers with plasma exchange in pregnancy

“…As can be seen from Table I, plasma exchange, using the Asahi membrane separator, produces a rapid decrease in levels of AFP and hCG during the procedure, with rebound to essentially normal levels by 18 hours postexchange. The rapid rebound in AFP as shown in Figure 2 may, in part, explain some of the improvement in myasthenia gravis treated with plasma exchange in pregnancy since AFP has been reported to block binding of myasthenia gravis antibody to acetylcholine receptors [14,19]. The rapid rebound in hCG is consistent with the case report of Shechter et al who reported hCG to be "normal" through week 24 of pregnancy in a patient receiving frequent plasma exchange [6].…”

“…Plasma exchange is an accepted therapy for a number of diseases in nonpregnant patients. In pregnancy, plasma exchange has been performed safely for both non-pregnancy-related diseases such as GBS [ 1,2], myasthenia gravis [ 14,151, and TTP [ 1,331 as well as some specific report of improved uteroplacental circulation in a patient with familial hypercholesterolemia treated with long-term plasma exchange during pregnancy [4]. Despite the relative safety of plasma exchange in pregnancy, to the best of our knowledge the current report is the first to document the clearance and rebound of AFP, hCG, and FE with plasma exchange during pregnancy.…”

Effects on feto‐placental markers with plasma exchange in pregnancy

“…As can be seen from Table I, plasma exchange, using the Asahi membrane separator, produces a rapid decrease in levels of AFP and hCG during the procedure, with rebound to essentially normal levels by 18 hours postexchange. The rapid rebound in AFP as shown in Figure 2 may, in part, explain some of the improvement in myasthenia gravis treated with plasma exchange in pregnancy since AFP has been reported to block binding of myasthenia gravis antibody to acetylcholine receptors [14,19]. The rapid rebound in hCG is consistent with the case report of Shechter et al who reported hCG to be "normal" through week 24 of pregnancy in a patient receiving frequent plasma exchange [6].…”

“…Plasma exchange is an accepted therapy for a number of diseases in nonpregnant patients. In pregnancy, plasma exchange has been performed safely for both non-pregnancy-related diseases such as GBS [ 1,2], myasthenia gravis [ 14,151, and TTP [ 1,331 as well as some specific report of improved uteroplacental circulation in a patient with familial hypercholesterolemia treated with long-term plasma exchange during pregnancy [4]. Despite the relative safety of plasma exchange in pregnancy, to the best of our knowledge the current report is the first to document the clearance and rebound of AFP, hCG, and FE with plasma exchange during pregnancy.…”

Preeclampsia from a renal point of view: Insides into disease models, biomarkers and therapy

“…In 1986 a successful use of plasmapheresis during pregnancy was reported in a patient with unusually fulminant, antibody-negative myasthenia gravis [107] . Another case report has suggested that PE may be a successful treatment for pregnant women with antiphospholipid syndrome [108] .…”

Міастенія Ґравіс І Вагітність

“…Пацієнтка народила немовля з перехідною міастенією, але з нормальним розвитком легень і без вад розвитку. Імовірно, лікування покращило перебіг цієї вагітності порівняно з двома попередніми [5].…”

Effects on feto‐placental markers with plasma exchange in pregnancy

“…As can be seen from Table I, plasma exchange, using the Asahi membrane separator, produces a rapid decrease in levels of AFP and hCG during the procedure, with rebound to essentially normal levels by 18 hours postexchange. The rapid rebound in AFP as shown in Figure 2 may, in part, explain some of the improvement in myasthenia gravis treated with plasma exchange in pregnancy since AFP has been reported to block binding of myasthenia gravis antibody to acetylcholine receptors [14,19]. The rapid rebound in hCG is consistent with the case report of Shechter et al who reported hCG to be "normal" through week 24 of pregnancy in a patient receiving frequent plasma exchange [6].…”

“…Plasma exchange is an accepted therapy for a number of diseases in nonpregnant patients. In pregnancy, plasma exchange has been performed safely for both non-pregnancy-related diseases such as GBS [ 1,2], myasthenia gravis [ 14,151, and TTP [ 1,331 as well as some specific report of improved uteroplacental circulation in a patient with familial hypercholesterolemia treated with long-term plasma exchange during pregnancy [4]. Despite the relative safety of plasma exchange in pregnancy, to the best of our knowledge the current report is the first to document the clearance and rebound of AFP, hCG, and FE with plasma exchange during pregnancy.…”

Preeclampsia from a renal point of view: Insides into disease models, biomarkers and therapy

“…In 1986 a successful use of plasmapheresis during pregnancy was reported in a patient with unusually fulminant, antibody-negative myasthenia gravis [107] . Another case report has suggested that PE may be a successful treatment for pregnant women with antiphospholipid syndrome [108] .…”

Міастенія Ґравіс І Вагітність

“…Пацієнтка народила немовля з перехідною міастенією, але з нормальним розвитком легень і без вад розвитку. Імовірно, лікування покращило перебіг цієї вагітності порівняно з двома попередніми [5].…”

Effects on feto‐placental markers with plasma exchange in pregnancy

“…As can be seen from Table I, plasma exchange, using the Asahi membrane separator, produces a rapid decrease in levels of AFP and hCG during the procedure, with rebound to essentially normal levels by 18 hours postexchange. The rapid rebound in AFP as shown in Figure 2 may, in part, explain some of the improvement in myasthenia gravis treated with plasma exchange in pregnancy since AFP has been reported to block binding of myasthenia gravis antibody to acetylcholine receptors [14,19]. The rapid rebound in hCG is consistent with the case report of Shechter et al who reported hCG to be "normal" through week 24 of pregnancy in a patient receiving frequent plasma exchange [6].…”

“…Plasma exchange is an accepted therapy for a number of diseases in nonpregnant patients. In pregnancy, plasma exchange has been performed safely for both non-pregnancy-related diseases such as GBS [ 1,2], myasthenia gravis [ 14,151, and TTP [ 1,331 as well as some specific report of improved uteroplacental circulation in a patient with familial hypercholesterolemia treated with long-term plasma exchange during pregnancy [4]. Despite the relative safety of plasma exchange in pregnancy, to the best of our knowledge the current report is the first to document the clearance and rebound of AFP, hCG, and FE with plasma exchange during pregnancy.…”

Preeclampsia from a renal point of view: Insides into disease models, biomarkers and therapy

“…In 1986 a successful use of plasmapheresis during pregnancy was reported in a patient with unusually fulminant, antibody-negative myasthenia gravis [107] . Another case report has suggested that PE may be a successful treatment for pregnant women with antiphospholipid syndrome [108] .…”

Міастенія Ґравіс І Вагітність

“…Пацієнтка народила немовля з перехідною міастенією, але з нормальним розвитком легень і без вад розвитку. Імовірно, лікування покращило перебіг цієї вагітності порівняно з двома попередніми [5].…”