Successful Outcome of a Case of Acute Myeloid Leukemia With t(8;21)/AML-ETO Following Langerhans Cell Histiocytosis

Meng, Guangqiang; Wang, Jingshi; Huang, Jiancheng; Wang, Yini; Wei, Na; Wang, Zhao

doi:10.4274/tjh.galenos.2019.2019.0126

Cited by 1 publication

(1 citation statement)

References 16 publications

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“…7 Although previous cases have linked LCH with subsequent development of AML, the concurrent presentation of LCH and AML is uncommon. 8,9 The Histiocyte Society identified 22 adults who developed AML within 10 years after the diagnosis of LCH, of which 19 had received chemotherapy with leukemogenic potential. 7 The development of AML in such cases might be due to treatment side effects or other factors.…”

Section: F I G U R E 2 Langerhans Cells Histiocytosis Involving the B...mentioning

confidence: 99%

Concurrent Langerhans cell histiocytosis and acute myeloid leukemia: A rare presentation of a rare case

Gao,

Davis,

Dagrosa

et al. 2023

J Cutan Pathol

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A 72‐year‐old woman with no significant past medical history was admitted to the hospital for new‐onset of leukocytosis with neutropenia, anemia, and thrombocytopenia, as well as a pruritic skin eruption. She was found to have acute myeloid leukemia (AML) with myelomonocytic differentiation. Her skin eruption consisted of widespread hemorrhagic crusted papules on the scalp and trunk. A skin biopsy was performed, which revealed a proliferation of mononuclear cells in the dermis with prominent epidermotropism and positive expression of CD1a and langerin (CD207), supporting a diagnosis of Langerhans cell histiocytosis (LCH). LCH is an uncommon proliferative disorder of activated Langerhans cells, which generally presents in children. In adults, it is exceptionally infrequent. Associated malignancies and rare reports of AML developing in subsequent years after an initial presentation of LCH have been described. Here we present an unusual concurrent presentation of LCH and AML in an adult.

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Section: F I G U R E 2 Langerhans Cells Histiocytosis Involving the B...mentioning

confidence: 99%

Concurrent Langerhans cell histiocytosis and acute myeloid leukemia: A rare presentation of a rare case

Gao,

Davis,

Dagrosa

et al. 2023

J Cutan Pathol

View full text Add to dashboard Cite

show abstract

Successful Outcome of a Case of Acute Myeloid Leukemia With t(8;21)/AML-ETO Following Langerhans Cell Histiocytosis

Cited by 1 publication

References 16 publications

Concurrent Langerhans cell histiocytosis and acute myeloid leukemia: A rare presentation of a rare case

Concurrent Langerhans cell histiocytosis and acute myeloid leukemia: A rare presentation of a rare case

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