Successful management of gastrointestinal pythiosis in a dog using itraconazole, terbinafine, and mefenoxam

Hummel, James; Grooters, Amy M.; Davidson, Gigi; Jennings, Sydney; Nicklas, Jodi; Birkenheuer, Adam J.

doi:10.3109/13693786.2010.543705

Cited by 21 publications

(44 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Few single case reports have documented treatment success with marginal surgical excision and medical treatment using a combination of potassium iodide, itraconazole, and terbinafine, or Pythium immunotreatment, itraconazole, and terbinafine . Another case report described a positive response to medical treatment without surgical resection in a dog with gastric pythiosis after administration of itraconazole, terbinafine, and mefonoxam . It is difficult to determine whether surgical or medical intervention, or a combination of both, was responsible for the favorable outcomes in these dogs, but these results do indicate that combination treatment could be superior to itraconazole monotherapy.…”

Section: Discussionmentioning

confidence: 99%

“…Instead, as sterol auxotrophs, Pythium , Lagenidium , and related oomycetes incorporate sterols from their environments or hosts rather than producing them . Nonetheless, improvement or resolution of clinical disease has been described after treatment with ergosterol‐targeting drugs (most often itraconazole and terbinafine) in a small number of dogs with pythiosis as well as in a 2‐year‐old child …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Successful management of 3 dogs with colonic pythiosis using itraconzaole, terbinafine, and prednisone

Reagan

Marks

Maggiore

et al. 2019

Veterinary Internal Medicne

View full text Add to dashboard Cite

Gastrointestinal (GI) pythiosis is a severe and often fatal disease in dogs that traditionally has been poorly responsive to medical treatment. Although aggressive surgical resection with wide margins is the most consistently effective treatment, lesion location and extent often preclude complete resection. Recently, it has been suggested that the addition of anti‐inflammatory doses of corticosteroids may improve outcome in dogs with nonresectable GI pythiosis. This report describes 3 dogs with colonic pythiosis in which complete resolution of clinical signs, regression of colonic masses, and progressive decreases in serological titers were observed after treatment with itraconazole, terbinafine, and corticosteroids. This treatment protocol represents a promising treatment for dogs with GI pythiosis in which surgical intervention is not feasible.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Successful management of 3 dogs with colonic pythiosis using itraconzaole, terbinafine, and prednisone

Reagan

Marks

Maggiore

et al. 2019

Veterinary Internal Medicne

View full text Add to dashboard Cite

show abstract

“…Mefenoxam continues to be effective in controlling oomycete diseases in crops (Rebollar‐Alviter et al . , ), and has recently been used to treat infection of animals by Pythium insidiosum (Hummel et al ., ).…”

Section: Introductionmentioning

confidence: 97%

Sequence diversity in the large subunit of RNA polymerase I contributes to Mefenoxam insensitivity in Phytophthora infestans

Randall

Young

Sierotzki

et al. 2014

Molecular Plant Pathology

View full text Add to dashboard Cite

Phenylamide fungicides have been widely used for the control of oomycete-incited plant diseases for over 30 years. Insensitivity to this chemical class of fungicide was recorded early in its usage history, but the precise protein(s) conditioning insensitivity has proven difficult to determine. To determine the genetic basis of insensitivity and to inform strategies for the cloning of the gene(s) responsible, genetic crosses were established between Mefenoxam sensitive and intermediate insensitive isolates of Phytophthora infestans, the potato late blight pathogen. F1 progeny showed the expected semi-dominant phenotypes for Mefenoxam insensitivity and suggested the involvement of multiple loci, complicating the positional cloning of the gene(s) conditioning insensitivity to Mefenoxam. Instead, a candidate gene strategy was used, based on previous observations that the primary effect of phenylamide compounds is to inhibit ribosomal RNA synthesis. The subunits of RNA polymerase I (RNApolI) were sequenced from sensitive and insensitive isolates and F1 progeny. Single nucleotide polymorphisms (SNPs) specific to insensitive field isolates were identified in the gene encoding the large subunit of RNApolI. In a survey of field isolates, SNP T1145A (Y382F) showed an 86% association with Mefenoxam insensitivity. Isolates not showing this association belonged predominantly to one P. infestans genotype. The transfer of the 'insensitive' allele of RPA190 to a sensitive isolate yielded transgenic lines that were insensitive to Mefenoxam. These results demonstrate that sequence variation in RPA190 contributes to insensitivity to Mefenoxam in P. infestans.

show abstract

“…Em outro trabalho, no qual dez casos de pitiose equina foram observados em Pelotas/RS, com diferentes sinais clínicos, cinco destes animais apresentaram recuperação após a aplicação do imunoterápico (Frey Jr et al 2007). Em cães, a imunoterapia tem gerado resultados promissores , especialmente quando há combinação com outras formas de tratamentos, sobretudo havendo a associação com a quimioterapia (Hensel et al 2003, Hummel et al, 2011, Schmiedt et al 2012. Com o número crescente de relatos de pitiose em criações de ovinos no Brasil, há necessidade de pesquisas futuras a fim de buscar alternativas terapêuticas no controle desta importante enfermidade.…”

Section: Discussionunclassified

“…A eficácia dos tratamentos está associada ao tamanho e local da lesão, duração da enfermidade, estado fisiológico e nutricional do hospedeiro acometido (Headley & Junior 2004). Fármacos isolados ou em associação são empregados como alternativa de terapia em infecções humanas e animais (Hummel et al 2011, Sudjaritruk et al 2011, Argenta et al 2012, Schmiedt et al 2012. A imunoterapia tem sido outra ferramenta no tratamento da pitiose, mostrando boa eficácia especialmente em equinos infectados (Frey Jr et al 2007).…”

Section: Introductionunclassified

Pitiose em ovinos nos estados de Pernambuco e Bahia

et al. 2013

View full text Add to dashboard Cite

Pythiosis is a devastating infectious disease caused by an aquatic oomycete, Pythium insidioum, and affects animals and humans that inhabit wetlands. The disease is characterized mainly by granulomatous lesions in the hosts. The purpose of this study was to report the occurrence of pythiosis in sheep in the states of Pernambuco (PE) and Bahia (BA), Northeastern Brazil, as well as to evaluate the efficacy of an immunotherapic against ovine pythiosis. Blood samples were collected from 53 sheep, 49 from flocks in counties located in PE and four from BA. Seven sheep showed clinical signs of ovine pythiosis; one of them was submitted to euthanasia and its head and submandibular lymph node was collected and sent for histopathologic and mycological analyses. Other six sheep were treated with an immunotherapic. During the treatment the animals were kept in the Sheep Industry Sector facilities at Univasf/Petrolina-PE. ELISA, fungal culture and polymerase chain reaction (PCR) methods were used to confirm the diagnosis of clinical ovine pythiosis in the sheep flock. At microscopic examination of the material collected from the nasal cavity of a sheep euthanized was observed a focally extensive area of necrosis with presence of diffuse infiltration of intact and degenerated neutrophils bordering the cartilage. Only one sheep showed clinical cure, indicating efficiency in the pythiosis treatment of 16.7% (1/6). Ovine pythiosis has been increasing in several municipalities of PE and BA. In this context, the immunotherapy may be an alternative to be searched. Therefore, further studies are needed to investigate the effect of immunotherapy on ovine pythiosis. mação de lesões com aspecto granulomatoso nos hospedeiros. Neste trabalho, relatou-se a ocorrência da pitiose em ovinos nos estados de Pernambuco (PE) e Bahia (BA), Nordeste do Brasil, bem como foi avaliada a eficácia de um imunoterápico frente a esta enfermidade. Amostras de sangue de 53 ovinos foram coletadas, sendo 49 animais oriundos de propriedades localizadas em PE e quatro animais provenientes da BA. Sete ovinos demonstraram sinais clínicos de pitiose ovina. Um dos animais foi submetido à eutanásia e sua cabeça e linfonodo submandibular foram coletados e enviados para análises laboratoriais. Seis ovinos foram submetidos à imunoterapia, sendo mantidos nas instalações do setor de ovinocultura da Univasf/Petrolina--PE durante o tratamento. As técnicas de ELISA, cultura fúngica e reação em cadeia da polimerase (PCR) foram utilizadas como métodos diagnósticos da pitiose ovina, sendo

show abstract

Successful management of gastrointestinal pythiosis in a dog using itraconazole, terbinafine, and mefenoxam

Cited by 21 publications

References 12 publications

Successful management of 3 dogs with colonic pythiosis using itraconzaole, terbinafine, and prednisone

Successful management of 3 dogs with colonic pythiosis using itraconzaole, terbinafine, and prednisone

Sequence diversity in the large subunit of RNA polymerase I contributes to Mefenoxam insensitivity in Phytophthora infestans

Pitiose em ovinos nos estados de Pernambuco e Bahia

Contact Info

Product

Resources

About