volume 272, issue 1-2, P189-193 2004
DOI: 10.1016/j.ijpharm.2003.12.017
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Abstract: The possibility of developing a quantitative relationship between molecular structure and lymphatic transfer of lipophilic compounds co-administered with a long-chain triglyceride vehicle was examined. Molecular descriptors were calculated using the computer program VolSurf, and lymphatic transfer data were derived from the literature. A significant structure-property relationship was established using partial least squares, projection to latent structures statistics (PLS). R(2)X was 0.77, R(2)Y was 0.83 and t…

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