Successful double-lung transplantation from a donor previously infected with SARS-CoV-2

Ceulemans, Laurens J.; Slambrouck, Jan Van; Leyn, Paul De; Decaluwé, Herbert; Veer, Hans Van; Depypere, Lieven; Ceuterick, Vincent; Verleden, Stijn E.; Vanstapel, Arno; Desmet, Stefanie; Maes, Piet; Ranst, Marc Van; Lormans, Piet; Meyfroidt, Geert; Neyrinck, Arne; Vanaudenaerde, Bart M.; Wijngaerden, Eric Van; Bos, Saskia; Godinas, Laurent; Carmeliet, Peter; Verleden, Geert M.; Raemdonck, Dirk Van; Vos, Robin

doi:10.1016/s2213-2600(20)30524-5

Cited by 47 publications

(61 citation statements)

References 22 publications

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“…As yet, there is no published evidence of transmission of COVID‐19 from a donor to a recipient. Although the number of transplants performed from COVID‐19‐positive donors remains low, the first single case report in lung transplantation has been published 13 . In line with NHSBT guidance, donors who have previously tested positive and recovered (referring to a period of at least 28 days from full clinical recovery) may still be considered for organ donation, with liaison with microbiology/virology clinicians.…”

Section: Discussionmentioning

confidence: 99%

The impact of the SARS‐CoV‐2 pandemic and COVID‐19 on lung transplantation in the UK: Lessons learned from the first wave

Hardman

Sutcliffe

Hogg

et al. 2021

Clinical Transplantation

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Background Lung transplantation is particularly susceptible to the impact of the severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) pandemic, and evaluation of changes to practice is required to inform future decision‐making. Methods A retrospective review of the UK Transplant Registry (UKTR) and national survey of UK lung transplant centers has been performed. Results There was geographic variation in the prevalence of COVID‐19 infection across the UK. The number of donors fell by 48% during the early pandemic period. Lung utilization fell to 10% (compared with 24% for the same period of 2019). The number of lung transplants performed fell by 77% from 53, March to May 2019, to 12. Seven (58%) of these were performed in a single‐center, designated “COVID‐light.” The number of patients who died on the lung transplant waiting list increased, compared to the same period of 2019 ( p = .0118). Twenty‐six lung transplant recipients with confirmed COVID‐19 infection were reported during the study period. Conclusion As the pandemic continues, reviewing practice and implementing the lessons learned during this period, including the use of robust donor testing strategies and the provision of “COVID‐light” hospitals, are vital in ensuring the safe continuation of our lung transplant program.

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Section: Discussionmentioning

confidence: 99%

The impact of the SARS‐CoV‐2 pandemic and COVID‐19 on lung transplantation in the UK: Lessons learned from the first wave

Hardman

Sutcliffe

Hogg

et al. 2021

Clinical Transplantation

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“…As yet, there is no published evidence of transmission of COVID‐19 from a donor to a recipient, although the number of transplants performed from COVID‐19‐positive donors remains low. The first single case report of a COVID‐19‐positive donor successfully resulting in lung transplantation has been published, 12 and, as the pandemic continues, and the number of people within the general population who have previously tested positive for COVID‐19 increases, new questions, including time since exposure and confidence in viral testing, will need to be answered, to ensure safe and on‐going utilization of donors. National guidance in the UK will no doubt to evolve as the pandemic continues.…”

Section: Discussionmentioning

confidence: 99%

Heart transplantation in the UK during the first wave of the SARS‐CoV‐2 pandemic

Hardman

Sutcliffe

Hogg

et al. 2021

Clinical Transplantation

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Background We aim to evaluate practice and understand the impact of the first wave of the SARS‐CoV‐2 pandemic on heart transplantation in the UK. Methods A retrospective review of the UK Transplant Registry (UKTR) and a national survey of UK heart transplant centers have been performed. The early pandemic period is defined here as 1 March to 31 May 2020. Results There was geographic variation in the prevalence of COVID‐19 across the UK. All centers reported adaptations to maintain the safety of their staff, candidate, and recipient populations. The number of donors fell by 31% during the early pandemic period. Heart utilization increased to 35%, compared to 26% during the same period of 2019. The number of heart transplants was well maintained, across all centers, with 38 performed, compared to 41 during the same period of 2019, with no change in 30‐day survival. Twenty‐seven heart transplant recipients with confirmed COVID‐19 infection were reported during the study period. Conclusion All UK heart transplant centers have successfully adapted their programs to overcome the challenges of staff redeployment and ICU and hospital resource limitation, associated with the pandemic, whilst continuing heart transplant activity. On‐going evaluation of practice changes, with sharing of lessons learned, is required as the pandemic continues.

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“…[123][124][125][126][127][128][129][130][131][132][133] There are several concerns regarding this patient group, some of which have been discussed in the previous paragraph, with the additional concerns of possible transmission of disease via the donor lung, hypercoagulability due to COVID-19, concomitant infections, immune dys-regulation, and prolonged critical illness of the patients. [123][124][125][126][127][128][129][132][133][134][135] Short-term survival rates are acceptable in highly selected patients, but more experience is needed to evaluate long-term outcomes in larger cohorts. 124,125,127,132,133,135…”

Section: Post-covid-19 Acute Respiratory Distress Syndromementioning

confidence: 99%

“…[123][124][125][126][127][128][129][132][133][134][135] Short-term survival rates are acceptable in highly selected patients, but more experience is needed to evaluate long-term outcomes in larger cohorts. 124,125,127,132,133,135…”

Section: Post-covid-19 Acute Respiratory Distress Syndromementioning

confidence: 99%

Selection Criteria for Lung Transplantation: Controversies and New Developments

Beeckmans

Bos

Vos

2021

Semin Respir Crit Care Med

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Lung transplantation is an accepted therapeutic option for end-stage lung diseases. The imbalance between limited availability and vast need of donor organs necessitates careful selection of recipient candidates, ensuring the best possible utilization of the scarce resource of organs. Nonetheless, possible lung transplant candidates who could experience a meaningful improvement in survival and quality of life should not be excluded solely based on the complexity of their case. In this review, controversial issues or difficult limitations for lung transplantation, and new developments in recipient selection criteria, are discussed, which may help broaden recipient eligibility for lung transplantation without compromising long-term outcomes.

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Successful double-lung transplantation from a donor previously infected with SARS-CoV-2

Abstract: Lung transplantation from a donor previously infected with SARS-CoV-2

Cited by 47 publications

References 22 publications

The impact of the SARS‐CoV‐2 pandemic and COVID‐19 on lung transplantation in the UK: Lessons learned from the first wave

The impact of the SARS‐CoV‐2 pandemic and COVID‐19 on lung transplantation in the UK: Lessons learned from the first wave

Heart transplantation in the UK during the first wave of the SARS‐CoV‐2 pandemic

Selection Criteria for Lung Transplantation: Controversies and New Developments

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