Successful Colchicine Therapy in a Patient With Follicular Bronchiolitis Presumed to Be Asthma

Göksel, Özlem; Nart, Denız; Ergönül, Ayşe Gül; Sever, Fidan; Göksel, Tuncay

doi:10.4187/respcare.03610

Cited by 3 publications

(4 citation statements)

References 16 publications

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“…In primary follicular bronchiolitis, there is no apparent underlying cause. The secondary follicular bronchiolitis is usually associated with connective tissue disorder, immunodeficiency syndromes, infections and obstructive airway diseases like COPD and asthma 1 2…”

Section: Discussionmentioning

confidence: 99%

Perplexing case of lung mass perfectly mimicking a malignancy

Alqurashi

Ahmed²,

Alsulami

et al. 2019

BMJ Case Rep

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A 35-year-old man, a known asthmatic and with a history of smoking presented with a history of recurrent episodes of mild haemoptysis. On examination, there was decreased intensity of breath sounds on the right infraclavicular area. The chest X-ray and CT chest showed a mass in right upper lobe with nodules in the other lobe. The VAT showed large heavily vascularised mass with surface laden with multiple nodules. The wedge resection of the mass was taken and sent for histopathology examination. The biopsy result showed picture suggestive of connective tissue disease associated follicular bronchiolitis. The patient did not have any signs or symptoms of connective tissue disease. However he was positive for Rheumatoid factor, ANA, anti-RO, anti-CCP antibodies. He was started on steroids and azathioprine. After 6 months of treatment, the size of the mass and nodules reduced by 50% and ESR was reduced to 5 from 75.

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Section: Discussionmentioning

confidence: 99%

Perplexing case of lung mass perfectly mimicking a malignancy

Alqurashi

Ahmed²,

Alsulami

et al. 2019

BMJ Case Rep

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“…Mediastinal and/or hilar lymphadenopathy on chest imaging were also seen in some of our cases, which could be related to the underlying diseases, such as MCD, PSS and CTD. Infections and small airway diseases are accompanied by the changes of pathological FB 2 , 23 , 24 . The infections of legionella pneumophilia and mycobacterium avium complex could give rise to the development of FB 23 , 25 .…”

Section: Discussionmentioning

confidence: 99%

“…Goksel et al . reported FB associated with RA that was controlled successfully by colchicine after she did not respond to systemic steroid therapy 2 . However, Kinane et al .…”

Section: Discussionmentioning

confidence: 99%

“…It can be generally classified into primary and secondary form. Secondary FB is usually associated with multiple systemic and pulmonary diseases such as connective tissue disease (CTD) and immunodeficiency, infections, interstitial lung disease (ILD), airway inflammatory diseases 2 , 3 . Primary (idiopathic) form of FB is more common in children than in adults 4 , 5 .…”

Section: Introductionmentioning

confidence: 99%

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The Clinical Characteristics and Outcomes of Follicular Bronchiolitis in Chinese Adult Patients

Zhao

et al. 2018

Sci Rep

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Follicular bronchiolitis (FB) is a rare interstitial lung disease (ILD) and has been reported in diverse clinical contexts. Six FB patients demonstrated by surgical lung biopsy (SLB) were reviewed between 2009 and 2017 from Nanjing Drum Tower Hospital in China. The average age of subjects was 42 years old (range: 31–55 years). The clinical symptoms were very mild. The laboratory findings showed elevated Erythrocyte sedimentation rate (ESR) and serum globulin and anemia. Pulmonary function tests were normal in four cases. Five cases had underlying diseases, such as, Sjo¨gren’s syndrome, multi-centric castlemans’ disease, idiopathic pneumonia with autoimmune features and abscess. Five cases presented as interstitial lung disease (ILD) on chest imaging with centrilobular or peribronchiolar nodules, ground glass opacities, interlobular septal thickening, cysts and bronchiectasis. Isolated mass was in one patient. The histopathology suggested the changes of FB in all subjects. Prednisone and/or cyclophosphamide were used in four cases, one did the surgery and the other was clinically monitored. All cases were alive at the end of follow up. The adult patients of FB usually have mild symptoms, ILD and underlying diseases. The definite diagnosis needs SLB. The prognosis is depended on their underlying conditions.

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