Subungual melanoma in situ: two independent streaks in one nail bed

Clarkson, James H. W.; McAllister, Murdoch K.; Cliff, S.; Powell, Barry

doi:10.1054/bjps.2001.3782

Cited by 33 publications

(25 citation statements)

References 3 publications

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“…Therefore, the currently recommended treatment for in situ or minimally invasive SUM is considered WLE with a narrow surgical margin, followed by SG. Although this strategy is becoming more common, there is limited evidence available regarding this procedure, and the recommendation for this strategy is based on a number case reports and series (<10 cases) (Table ) . Therefore, we conducted this retrospective study to evaluate WLE for in situ or invasive SUM (including >0.5‐mm thick tumors) in a larger patient population.…”

Section: Discussionmentioning

confidence: 99%

“…Although this strategy is becoming more common, there is limited evidence available regarding this procedure, and the recommendation for this strategy is based on a number case reports and series (<10 cases) ( Table 4). [9][10][11][12][13][14][17][18][19][20] Therefore, we conducted this retrospective study to evaluate WLE for in situ or invasive SUM (including >0.5-mm thick tumors) in a larger patient population. Regarding in situ lesions, Lazar et al 11 reported a series of nine patients with in situ SUM who were treated using WLE and full-thickness SG, and noted that no recurrence was observed after a mean follow-up period of 50.4 months.…”

Section: Discussionmentioning

confidence: 99%

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Effects of non‐amputative wide local excision on the local control and prognosis of in situ and invasive subungual melanoma

Nakamura

Ohara

Kishi

et al. 2015

The Journal of Dermatology

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Subungual melanomas (SUM) are rare, and amputation is often required. Non-amputative wide local excision (WLE) of the nail unit with the periosteum of the distal phalanx, followed by skin graft, has been accepted for in situ or SUM of 0.5 mm or less thickness. However, previous reports have included a limited number of cases, and not all more than 0.5-mm thick SUM exhibit invasion or attachment to the distal phalanx. The aim of the present study was to investigate the local recurrence and prognosis for in situ, minimally invasive and invasive SUM that were treated using WLE. We retrospectively reviewed 50 patients with in situ (n = 48) or minimally invasive SUM (n = 2) (in situ or minimally invasive group) and 12 patients with more than 0.5-mm thick invasive SUM (invasive group) who were treated using WLE. All patients survived the follow-up period (24-207 months), although four patients with in situ SUM experienced local recurrence at the lateral margin and re-excision was required. In the invasive group, no patients experienced local recurrence, although one patient (8.3%) developed nodal metastasis at 86 months and regional lymph node dissection was required. WLE may provide acceptable local control for in situ and intermediate thickness SUM, without compromising the vital prognosis. However, a larger randomized prospective study with long-term follow up is required to evaluate adequately the risks associated with a non-amputative WLE for in situ and invasive SUM.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effects of non‐amputative wide local excision on the local control and prognosis of in situ and invasive subungual melanoma

Nakamura

Ohara

Kishi

et al. 2015

The Journal of Dermatology

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“…3), which is defined as a Breslow tumor thickness (TT) ≤0.5 mm [33][34][35][36][37][38]. There have also been a few case reports of two-step surgeries using artificial dermis tissue for the tentative coverage of the defect after local excision, followed by skin graft coverage after the histopathological confirmation of negative surgical margins [39,40].…”

Section: In Situ or Minimally-invasive Summentioning

confidence: 99%

Current Surgical Management of Acral Lentiginous Melanoma

Nakamura¹,

Teramoto²,

Sato³

et al. 2015

Melanoma - Current Clinical Management and Future Therapeutics

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“…The tumor may present as nail plate loss, a non-healing ulcer, a tumor nodule or subungual pigmentation which often extends into the nail folds 7,8 . The incidence of amelanotic melanoma in all melanomas is low, although the subungual region seems to be an area of predilection for amelanotic melanoma in 15 to 25% of cases 4,6 .…”

Section: Case Reportmentioning

confidence: 99%