Subungual keratoacanthoma. Report of a case and review of the literature

Keeney, G. L.

doi:10.1001/archderm.124.7.1074

Cited by 8 publications

(12 citation statements)

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“…SUKA has an aggressive clinical course, and may spontaneously resolve; still, this is rare, and the literature does not support an accepted safe period of observation for SUKA [9]. Initially, local excision and curettage are sufficient for treatment, but amputation may be necessary either because of the aggressive nature of the disease, or extensive osteolysis or recurrence after excision and curettage [1,2,10]. There is no certain recurrence ratio, but most of the recurrences occurred within the first 5 months [2].…”

Section: Discussionmentioning

confidence: 99%

Relationship between Human Papilloma Virus and Subungual Keratoacanthoma: Two Case Reports and the Outcomes of Surgical Treatment

Göktay

Kaynak

Güneş

et al. 2016

Skin Appendage Disord

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Subungual keratoacanthoma (SUKA) is a rare form of keratoacanthoma, with the majority of the lesions appearing as rapidly growing, painful hyperkeratotic masses located under the distal nail plate of the thumb. In some cases, SUKA causes damage to the underlying bone. The first case presented here was treated by surgical excision alone, and human papilloma virus (HPV) type 6 was detected in the tissue samples. The second case was treated by surgical excision plus curettage; however, HPV was not detected, and tumor cells were not found in the curettage material. There was near complete improvement in both the clinical appearance and the distal phalanx destruction, with no recurrence at the final follow-up in either patient (30 and 14 months, respectively). Overall, simple excision alone or in combination with curettage seemed to be sufficient in the treatment of SUKA; however, the etiopathogenetic role of HPV in SUKA remains controversial, as in its classical form.

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Section: Discussionmentioning

confidence: 99%

Relationship between Human Papilloma Virus and Subungual Keratoacanthoma: Two Case Reports and the Outcomes of Surgical Treatment

Göktay

Kaynak

Güneş

et al. 2016

Skin Appendage Disord

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“…Despite exceptional cases of spontaneous resolutions [9], this rare painful and destructive variant of KA is regarded by some authors as a low-grade carcinoma, capable of local invasion and extension to the bone [10, 11]. SKA effectively differs from typical KA in regard to its occurrence on non-hair-bearing skin, a usual lack of typical histological collarette, and a tendency to deep invasion [12]. Characteristically its growth is rapid (within a matter of weeks, often preceded by a history of trauma) and separates the nail plate from the nail bed.…”

Section: Discussionmentioning

confidence: 99%

Solitary Subungual Keratoacanthoma Arising in an MSH2 Germline Mutation Carrier: Confirmation of a Relationship by Immunohistochemical Analysis

Stoebner

Fabre²,

Delfour³

et al. 2009

Dermatology

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Background: Muir-Torre syndrome (MTS) is an autosomal dominant disorder characterized by the concurrent or sequential development of at least 1 sebaceous gland tumor or keratoacanthoma and 1 or more internal malignancies. It is actually considered as a variant of hereditary nonpolyposis colorectal cancer (HNPCC) as both MTS and HNPCC are more often associated with germline mutations in the DNA mismatch repair (MMR) gene. Objective andMethods: We report the case of MTS diagnosed after the occurrence of a solitary subungual keratoacanthoma (SKA) in a man with a well-known family history of HNPCC and who is carrying a constitutional 1–7 deletion in the MSH2 MMR gene. Results: The link between the germline mutation and the skin tumor was reinforced by immunohistochemical staining. MSH2 immunoreactivity was decreased in SKA tumoral cells when compared to normal adjacent epidermis and to 5 cases of sporadic KA used as controls. Conclusion: This observation indicates that a solitary SKA may be the first clinical manifestation of MTS and brings up the relevance for regular dermatological screening for MTS-associated skin lesions among gene carriers (and symptomatic individuals) for HNPCC syndrome.

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“…SUKA is a rare tumour associated with a well-defined cup-shaped lytic defect of the underlying bone. 1 It most commonly occurs in Caucasian men, having a predilection for the hands. The differential diagnosis includes subungual SCC, verrucous carcinoma, viral wart and epidermoid cyst.…”

Section: Reportmentioning

confidence: 99%

“…2,3 Both SUKA and subungual SCC may present with pain, swelling and inflammation of the nail bed. 4 However, SUKA characteristically arises in the fifth decade and develops rapidly over a period of weeks, 1 whereas subungual SCC arises most commonly in the seventh decade and develops over several months or insidiously over many years and may be misdiagnosed as chronic paronychia. 3 Underlying bone erosion is common in SUKA and considered to be resorption rather than invasion, occurring without sclerosis or periosteal reaction.…”

Section: Reportmentioning

confidence: 99%

“…The more protracted nature of subungual SCC typically results in periosteal thickening and reactive sclerosis of the underlying bone. 1 The potential for lytic bony destruction should be considered with any subungual expansile lesion. 6 SUKA differs from a typical keratoacanthoma (KA) as it arises in nonhair-bearing skin and lacks the distinctive epithelial collarette.…”

Section: Reportmentioning

confidence: 99%

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Spontaneous regression of subungual keratoacanthoma with reossification of underlying distal lytic phalynx

2005

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A 45-year-old man presented with a rapidly enlarging keratotic lesion of the distal subungual right middle finger. An X-ray of the digit revealed a well-defined cup-shaped lytic lesion of the phalynx underlying the subungual nodule. The lesion resolved spontaneously with reossification of the underlying bony defect. The clinical history and X-ray is consistent with a diagnosis of spontaneously resolving subungual keratoacanthoma.

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Subungual keratoacanthoma. Report of a case and review of the literature

Cited by 8 publications

References 0 publications

Relationship between Human Papilloma Virus and Subungual Keratoacanthoma: Two Case Reports and the Outcomes of Surgical Treatment

Relationship between Human Papilloma Virus and Subungual Keratoacanthoma: Two Case Reports and the Outcomes of Surgical Treatment

Solitary Subungual Keratoacanthoma Arising in an MSH2 Germline Mutation Carrier: Confirmation of a Relationship by Immunohistochemical Analysis

Spontaneous regression of subungual keratoacanthoma with reossification of underlying distal lytic phalynx

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