Subtyping Major Depressive Disorder

Lichtenberg, Pesach; Belmaker, Robert H.

doi:10.1159/000286957

Cited by 108 publications

(89 citation statements)

References 77 publications

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“…Exclusive reliance on psychiatric diagnostic criteria has impoverished the clinical process and does not reflect the complex thinking that underlies decisions in psychiatric practice 61 . Identifying and subtyping demoralization in the setting of medical disease may yield improved targets for research and treatment trials, as is currently advocated in major depression [62][63][64] .…”

Section: Discussionmentioning

confidence: 99%

Subtyping demoralization in the medically ill by cluster analysis

et al. 2013

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ITALY ABSTRACT -Background and Objectives:There is increasing interest in the issue of demoralization, particularly in the setting of medical disease. The aim of this investigation was to use both DSM-IV comorbidity and the Diagnostic Criteria for Psychosomatic Research (DCPR) in order to characterize demoralization in the medically ill.Methods: 1700 patients were recruited from 8 medical centers in the Italian Health System and 1560 agreed to participate. They all underwent a cross-sectional assessment with DSM-IV and DCPR structured interviews. 373 patients (23.9%) received a diagnosis of demoralization. Data were submitted to cluster analysis.Results: Four clusters were identified: demoralization and comorbid depression; demoralization and comorbid somatoform/adjustment disorders; demoralization and comorbid anxiety; demoralization without any comorbid DSM disorder. The first cluster included 27.6% of the total sample and was characterized by the presence of DSM-IV mood disorders (mainly major depressive disorder). The second cluster had 18.2% of the cases and contained both DSM-IV somatoform (particularly, undifferentiated somatoform disorder and hypochondriasis) and adjustment disorders. In the third cluster (24.7%), DSM-IV anxiety disorders in comorbidity with demoralization were predominant (particularly, generalized anxiety disorder, agoraphobia, panic disorder and obsessive-compulsive disorder). The fourth cluster had 29.5% of the patients and was characterized by the absence of any DSM-IV comorbid disorder.Conclusions: The findings indicate the need of expanding clinical assessment in the medically ill to include the various manifestations of demoralization as encompassed by the DCPR. Subtyping demoralization may yield improved targets for psychosomatic research and treatment trials.

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Section: Discussionmentioning

confidence: 99%

Subtyping demoralization in the medically ill by cluster analysis

et al. 2013

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“…Subtypes of depression are proposed to exist that differ in etiology, manifestation and are responsive to different kinds of antidepressant treatment [49] . The existence of different subtypes of depression in cardiac patients could explain why some subgroups of depressed cardiac patients have worse prognosis than others.…”

Section: Discussionmentioning

confidence: 99%

Onset and Recurrence of Depression as Predictors of Cardiovascular Prognosis in Depressed Acute Coronary Syndrome Patients: A Systematic Review

Zuidersma

Thombs

Jonge

2011

Psychother Psychosom

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Background: Depression after acute coronary syndrome (ACS) is associated with worse cardiac outcomes. This systematic review evaluated whether depressed ACS patients are at differential risk depending on the recurrence and timing of onset of depressive episodes. Methods: MEDLINE, EMBASE and PsycINFO were searched from inception to 11 April 2009. Additionally, reference lists and recent tables of contents of 34 selected journals were manually searched. Eligible studies evaluated cardiovascular outcomes for subgroups of ACS patients with depression or depressive symptoms according to recurrence or onset. Results: Six studies were included that reported outcomes for subgroups of ACS patients with first-ever versus recurrent depression. Four of these reported also outcomes for post-ACS onset versus pre-ACS onset depression, and incident versus nonincident depression. Worse outcomes (odds ratio >1.4) were reported for ACS patients with first-ever depression in 3 of 6 studies (1 study p < 0.05), for patients with post-ACS onset depression in 3 of 4 studies (1 study p < 0.05, but better outcomes in one study) and for patients with incident depression in 2 of 4 studies (no studies p < 0.05). Conclusions: Although it is still suggested that ACS patients with first and new-onset depression are at particularly increased risk of worse prognosis, the inconsistent results from the studies included in this systematic review show that there is no consistent evidence to support such statements.

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“…Считается, что используемые в настоящее время антидепрессанты не вызывают зависимости [14,18]. Вместе с тем серьезной проблемой остается воз-можность развития симптомов отмены после резко-го прекращения их длительного применения.…”

Section: Introductionunclassified

“…Прак-тически для всех групп антидепрессантов описаны симптомы, вызванные резкой отменой длительного приема -тревога, нарушения сна, расстройства движения, маниакальные состояния, панические атаки, нарушение функций желудочно-кишечно-го тракта и сердечной деятельности [11,14,22]. Следует отметить, что описанные явления трудно интерпретировать, если не сделать точной диагно-стической категоризации наблюдаемых нарушений у больных с различными формами депрессий [18].…”

Section: Introductionunclassified

The study of the effects of dipeptide mimetic of a brain derived neurotrophic factor with antidepressant activity during prolonged use and after withdrawal

Garibova

Леоновна²,

Krayneva

et al. 2018

Rev Clin Pharm Drug Ther

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The antidepressant activity of the GSB-106, dipeptide mimetic of the 4th loop of BDNF, during long-term use was studied in doses of 1.0 mg/kg and 5 mg/kg for. When comparing antidepressant activity in the “forced swimming Porsolt test” on the 14th and 28th day of administration, it was established that the antidepressant effect did not change. It was shown that a withdrawal of prolonged administration for 28 days did not lead to an increase in anxiety in the “elevated plus-maze test” and to the development of disturbances in the exploratory behavior of animals and motor activity in the “open field” test. It was concluded that during long-term administration of GSB-106 the tolerance for the main antidepressant effect did not developed, and cessation of long-term administration of GSB-106 did not lead to the development of withdrawal syndrome. (For citation: Garibova TL, Krayneva VA, Valdman EA, et al. The study of the effects of dipeptide mimetic of a brain derived neurotrophic factor with antidepressant activity during prolonged use and after withdrawal. Reviews on Clinical Pharmacology and Drug Therapy. 2018;16(1):28-33. doi: 10.17816/RCF16128-33).

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Subtyping Major Depressive Disorder

Cited by 108 publications

References 77 publications

Subtyping demoralization in the medically ill by cluster analysis

Subtyping demoralization in the medically ill by cluster analysis

Onset and Recurrence of Depression as Predictors of Cardiovascular Prognosis in Depressed Acute Coronary Syndrome Patients: A Systematic Review

The study of the effects of dipeptide mimetic of a brain derived neurotrophic factor with antidepressant activity during prolonged use and after withdrawal

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