Subthreshold depression is associated with impaired resting-state functional connectivity of the cognitive control network

Hwang, Jiwon; Egorova, Natalia; Xia, Yang; Zhang, W Y; Chen, J; Yang, Xiaojian; Hu, Lingyu; Sun, Sharon; Tu, Ya; Kong, Jian

doi:10.1038/tp.2015.174

Cited by 102 publications

(79 citation statements)

References 67 publications

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“…This result is consistent with previous resting state FC studies in StD patients (Hwang, Egorova, 2015, Li et al, 2014b, Ma et al, 2013). In a previous study, Ma and colleagues (Ma, Li, 2013) compared regional homogeneity (ReHo) changes of late-life individuals with StD to controls.…”

Section: Discussionsupporting

confidence: 93%

“…In another study on the same cohort of StD patients, Li and colleagues (Li, Ma, 2014b) found the StD group showed increased regional amplitude of low-frequency fluctuation (ALFF) in the anterior portion of the dorsal ACC (adACC), which also displayed increased FC with the dorsolateral prefrontal cortex and supplementary motor area, and decreased FC with the anterior insula, thalamus, and putamen. In a more recent study (Hwang, Egorova, 2015), based on the same data set, we found a significant resting state FC decrease between the DLPFC and the temporo-parietal junction (TPJ)/precuneus (the brain regions associated with the representation of self and other mental states) and the insula in StD subjects.…”

Section: Discussionmentioning

confidence: 53%

“…Please also see a previously published study for more details on the experimental procedure (Hwang et al, 2015). The data has been used in a previous study to investigate the functional connectivity of bilateral dorsal lateral prefrontal cortex changes between individuals with StD and healthy control.…”

Section: Methodsmentioning

confidence: 99%

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Enhanced default mode network connectivity with ventral striatum in subthreshold depression individuals

Hwang

Xin

et al. 2016

Journal of Psychiatric Research

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Subthreshold depression (StD) is a highly prevalent condition associated with increased service utilization and social morbidity. Nevertheless, due to limitations in current diagnostic systems that set the boundary for major depressive disorder (MDD), very few brain imaging studies on the neurobiology of StD have been carried out, and its underlying neurobiological mechanism remains unclear. In recent years, accumulating evidence suggests that the disruption of the default mode network (DMN), a network involved in self-referential processing, affective cognition, and emotion regulation, is involved in major depressive disorder. Using independent component analysis, we investigated resting-state default mode network (DMN) functional connectivity (FC) changes in two cohorts of StD patients with different age ranges (young and middle-aged, n= 57) as well as matched controls (n=79). We found significant FC increase between the DMN and ventral striatum (key region in the reward network), in both cohorts of StD patients in comparison with controls. In addition, we also found the FC between the DMN and ventral striatum was positively and significantly associated with scores on the Center for Epidemiologic Studies Depression Scale (CES-D), a measurement of depressive symptomatology. We speculate that this enhanced FC between the DMN and the ventral striatum may reflect a self-compensation to the lowered reward function.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 53%

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Enhanced default mode network connectivity with ventral striatum in subthreshold depression individuals

Hwang

Xin

et al. 2016

Journal of Psychiatric Research

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“…rsFC allows for the study of the function of one or several brain regions in relation to its functional network and how the network contributes to brain procedures (Hwang et al, 2015; Jessica S. Damoiseaux & Greicius, 2009). It has also widely been used to reveal the underlying mechanisms of different diseases (Sun et al, 2012; J.…”

Section: Introductionmentioning

confidence: 99%

Repeated acupuncture treatments modulate amygdala resting state functional connectivity of depressive patients

Wang

Liu

et al. 2016

NeuroImage: Clinical

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As a widely-applied alternative therapy, acupuncture is gaining popularity in Western society. One challenge that remains, however, is incorporating it into mainstream medicine. One solution is to combine acupuncture with other conventional, mainstream treatments. In this study, we investigated the combination effect of acupuncture and the antidepressant fluoxetine, as well as its underlying mechanism using resting state functional connectivity (rsFC) in patients with major depressive disorders.Forty-six female depressed patients were randomized into a verum acupuncture plus fluoxetine or a sham acupuncture plus fluoxetine group for eight weeks. Resting-state fMRI data was collected before the first and last treatments. Results showed that compared with those in the sham acupuncture treatment, verum acupuncture treatment patients showed 1) greater clinical improvement as indicated by Montgomery–Åsberg Depression Rating Scale (MADRS) and Self-Rating Depression Scale (SDS) scores; 2) increased rsFC between the left amygdala and subgenual anterior cingulate cortex (sgACC)/preguenual anterior cingulate cortex (pgACC); 3) increased rsFC between the right amygdala and left parahippocampus (Para)/putamen (Pu). The strength of the amygdala-sgACC/pgACC rsFC was positively associated with corresponding clinical improvement (as indicated by a negative correlation with MADRS and SDS scores). Our findings demonstrate the additive effect of acupuncture to antidepressant treatment and suggest that this effect may be achieved through the limbic system, especially the amygdala and the ACC.

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“…However, a related study performed on regular meditators and non-meditators suggests that repeated meditation training may be able to raise the efficiency of neural networks mobilized for task based attention and impulse control [24]. These neural activities recruited may activate default-mode network [25,26] that is an important role of depression [26], and promote precuneus structural changes [6] to elicit happy emotions and helped the patient or subject to produce psychological activities. In conclusion, the findings of our study suggests that during short term loosen up meditation increased percentage content and median power frequency of α-wave, and also increased sympathetic nerve activity in young subjects.…”

Section: Discussionmentioning

confidence: 99%

Short - Term Loosen Up Meditation Induced EEG and Autonomic Response in Healthy Japanese Students

Iwakuma¹,

Nakayama²,

Oshita³

et al. 2016

J Alt Med Res

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Meditation has been practiced beginning of ancient times, and recently has gained more attention as something that can be utilized by anyone, regardless of their location, age, or gender for health benefits. The present study was aimed to produce some basic data on the effects of short-term meditation, as assessed by measuring brain waves during meditation, on 15 healthy Japanese students. Experiments were conducted with the subjects' eyes closed. After watching a meditation video (of about nine minutes duration), subjects took a three-minute break before practicing voiceless self meditation.Frequency analysis of brain waves of the subjects during the meditation revealed that the strength of α wave tends to increase during the meditation. In addition, the content rate of M1 (a + b) α waves during meditation tended to be higher than during the rest or recovery periods, although this difference was not statistically significant. The content rate of M2 (a + b) α waves during meditation was higher than that during rest, while that for δ waves was much lower than that during rest. Relative to that during recovery, the content rate during meditation was significantly lower for M2 α waves but significantly higher for δ waves. The α waves showed significantly more intermediate frequencies during M1 and M2 meditation as compared to those during the rest period, but fewer were noted during recovery. The LF/HF values, which reflect sympathetic nerve activity, were significantly higher during both M1 and M2 meditation than during the rest period. However, relative to that during recovery, LF/HF during M2 meditation was significantly lower.One limitation of the present study is that the meditation period was comparatively short. In addition, many of the subjects were also inexperienced in meditation, which may have created more variability in the results. However, the present study clearly demonstrates that repeated practice of meditation may improve subject's attention to task activities as well as the effectiveness of the neural network recruited for impulse control.

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Subthreshold depression is associated with impaired resting-state functional connectivity of the cognitive control network

Cited by 102 publications

References 67 publications

Enhanced default mode network connectivity with ventral striatum in subthreshold depression individuals

Enhanced default mode network connectivity with ventral striatum in subthreshold depression individuals

Repeated acupuncture treatments modulate amygdala resting state functional connectivity of depressive patients

Short - Term Loosen Up Meditation Induced EEG and Autonomic Response in Healthy Japanese Students

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