Subsurface Tumor Ablation with Near-infrared Radiation using Intratumoral and Intravenous Injection of Nanoparticles

Paul, Anup; Bandaru, Nanda Kishor; Narasimhan, Arunn; Das, Sarit K.

doi:10.1260/1759-3093.5.2.69

Cited by 3 publications

(6 citation statements)

References 22 publications

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“…The obtained results have been validated with the previously performed (Paul et al, 2014a) experimental results by us on simulated tissue phantom embedded with LBVs. The maximum rise in temperature at the surface of tissue drops down significantly by 12°C due to the heat sink effect of Investigation of thermal damage of tissues LBV and it has been also observed that the maximum thermal damage parameter drops to 0.00075 from 1.5, which is insufficient for irreversible tissue damage.…”

Section: Discussionsupporting

confidence: 62%

“…The values of the optical properties and thermal properties have been explained in our previous paper (Paul et al, 2014a). A numerical software COMSOL multiphysics (COMSOL Multiphysics 4.3, Burlington, MA) was used to solve the conjugate heat transfer with a relative tolerance limit of 0.001 and absolute tolerance of 0.0001 in both velocity and temperature.…”

Section: Numerical Simulationmentioning

confidence: 99%

“…The laser heat deposition in different domain, namely, tissue, blood and blood vessel are dominated by their optical properties. The thermal properties of the tissue phantom has been measured and can be found in our previous paper (Paul et al, 2014a), the optical properties of tissue, blood vessel and blood were obtain from references Welch (1984), Palmer and Williams (1974) and Yang et al (2008).…”

Section: Governing Equationsmentioning

confidence: 99%

“…The model presented in this paper is validated with the experiment (Paul et al, 2014a) of laser irradiation on equivalent tissue phantom. A comparison of temperature distribution at the top tissue surface (below laser spot) is shown in Figure 2 and a good agreement with numerical has been obtained.…”

Section: Validationmentioning

confidence: 99%

“…Paul et al, 2014a) PredictedMeasured(Paul et al, : (a) Tissue in absence of LBV; (b) single vessel transiting tissue (SVTT). Laser power = 558 mW, spot size = 5 mm, depth of LBV = 2.5 mm, flow rate = 10 ml / min…”

mentioning

confidence: 99%

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Investigation of thermal damage of tissues embedded with large blood vessels during plasmonic photo-thermal heating (PPTH)

Paul

Narasimhan

Das

2016

Int Jnl of Num Meth for HFF

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If you would like to write for this, or any other Emerald publication, then please use our Emerald for Authors service information about how to choose which publication to write for and submission guidelines are available for all. Please visit www.emeraldinsight.com/authors for more information. About Emerald www.emeraldinsight.comEmerald is a global publisher linking research and practice to the benefit of society. The company manages a portfolio of more than 290 journals and over 2,350 books and book series volumes, as well as providing an extensive range of online products and additional customer resources and services. AbstractPurpose -The large blood vessels (LBV) would act as a heat sink and hence play a significant role during photo-thermal therapy. Gold nanoshell was considered as a high-heat absorbing agent in photo-thermal heating to reduce the cooling effect of LBV. The heat sink effect of LBV results in insignificant irreversible tissue thermal damage. The paper aims to discuss these issues. Design/methodology/approach -In this paper, the thermal history of tissue embedded with LBV during photo-thermal heating were calculated using finite element-based simulation technique. A volumetric laser source term based on modified Beer-Lambert law was introduced to model laser heating. The numerically predicted temperature drop was validated against that of previously performed experiments by the authors on tissue mimic embedded with simulated blood vessels. In the later part of the study, Arrhenius equation was coupled with the energy equation to investigate and report the irreversible thermal damage to the bio-tissues. Findings -The results obtained conclude that tissue with different orientation of blood vessels results in different thermal response at the tissue surface. Gold nanoshells were introduced into the laser irradiated tissue to overcome the cooling effect of LBV during plasmonic photo-thermal heating. The effect of size and concentration of nanoparticles on tissue heating were analyzed. The predicted damage parameter was much lower in case of tissue embedded with blood vessel than that predicted in case of bare tissue, which results in incomplete tissue necrosis. Finally, the effects of laser specification, blood vessel specification and blood perfusion on the tissue thermal damage were examined. Originality/value -The conjugate energy equations in conjunction with Arrhenius equation were solved numerically to predict the tissue irreversible damage embedded with LBV.

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Section: Discussionsupporting

confidence: 62%

Section: Numerical Simulationmentioning

confidence: 99%