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“…While abundant work in the isolated perfused heart has demonstrated that insulin at high concentrations stimulates the uptake and metabolism of glucose (7)(8)(9)(10), evidence that insulin at physiologic concentrations regulates heart glucose uptake in vivo is indirect (11). Furthermore, since in vivo insulin lowers plasma FFA levels by inhibiting lipolysis in adipose tissue (12), assessment of insulin's direct role in regulating heart glucose metabolism requires simultaneous estimation of heart fatty acid exchange.…”
Section: Introductionmentioning
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“…While abundant work in the isolated perfused heart has demonstrated that insulin at high concentrations stimulates the uptake and metabolism of glucose (7)(8)(9)(10), evidence that insulin at physiologic concentrations regulates heart glucose uptake in vivo is indirect (11). Furthermore, since in vivo insulin lowers plasma FFA levels by inhibiting lipolysis in adipose tissue (12), assessment of insulin's direct role in regulating heart glucose metabolism requires simultaneous estimation of heart fatty acid exchange.…”
Section: Introductionmentioning
“…ii. The nutritional, metabolic and hormonal regulation of human myocardial metabolism [91][92][93][94][95][96][97][98][99][100]. iii.…”
Section: Some Paradigm Shiftsmentioning