Substitution treatment of injecting opioid users for prevention of HIV infection

Abstract

Oral substitution treatment for injecting opioid users reduces drug-related behaviours with a high risk of HIV transmission, but has less effect on sex-related risk behaviours. The lack of data from randomised controlled studies limits the strength of the evidence presented in this review.

The impact of needle and syringe provision and opiate substitution therapy on the incidence of hepatitis C virus in injecting drug users: pooling of UK evidence

“…those who had injected in the last 4 weeks) and thus we will have under‐represented those who cease injecting during treatment in the analysis. In line with previous evidence, we show that OST and NSP, especially in combination, are associated with reductions in injecting risk [16,17,19].…”

The impact of needle and syringe provision and opiate substitution therapy on the incidence of hepatitis C virus in injecting drug users: pooling of UK evidence

“…those who had injected in the last 4 weeks) and thus we will have under‐represented those who cease injecting during treatment in the analysis. In line with previous evidence, we show that OST and NSP, especially in combination, are associated with reductions in injecting risk [16,17,19].…”

Impact of methadone on drug use and risky sex in China

“…Also consistent with the above consensus view, current enrollment in MMT was related to a greater reduction in drug use and injection than past enrollment in MMT (Baker, Kochan, Dixon, Wodak, & Heather, 1995). Our data also suggest that MMT may reduce risky sexual behaviors, a finding that is somewhat controversial in the literature (Abbott, Moore, Weller, & Delaney, 1998;Gowing et al, 2004;Magura, Rosenblum, & Rodriguez, 1998;Sorensen & Copeland, 2000). Our subjects who had participated in MMT may have had more chances to receive HIV risk reduction information and counseling, and this may explain why the MMT group was less likely to have multiple sexual partners and to have unprotected sex.…”

Methadone Maintenance Treatment Participant Retention and Behavioural Effectiveness in China: A Systematic Review and Meta-Analysis

“…The phenomenon of early drop-out is consistent with findings in international settings [112,113]. In comparison, the 12-month MMT retention rate in China is substantially lower than programs in other developed (60-85% [22,114,115,116]) and developing countries settings (62-82% [117,118]).…”

The impact of needle and syringe provision and opiate substitution therapy on the incidence of hepatitis C virus in injecting drug users: pooling of UK evidence

“…those who had injected in the last 4 weeks) and thus we will have under‐represented those who cease injecting during treatment in the analysis. In line with previous evidence, we show that OST and NSP, especially in combination, are associated with reductions in injecting risk [16,17,19].…”

Impact of methadone on drug use and risky sex in China

“…Also consistent with the above consensus view, current enrollment in MMT was related to a greater reduction in drug use and injection than past enrollment in MMT (Baker, Kochan, Dixon, Wodak, & Heather, 1995). Our data also suggest that MMT may reduce risky sexual behaviors, a finding that is somewhat controversial in the literature (Abbott, Moore, Weller, & Delaney, 1998;Gowing et al, 2004;Magura, Rosenblum, & Rodriguez, 1998;Sorensen & Copeland, 2000). Our subjects who had participated in MMT may have had more chances to receive HIV risk reduction information and counseling, and this may explain why the MMT group was less likely to have multiple sexual partners and to have unprotected sex.…”

Methadone Maintenance Treatment Participant Retention and Behavioural Effectiveness in China: A Systematic Review and Meta-Analysis

“…The phenomenon of early drop-out is consistent with findings in international settings [112,113]. In comparison, the 12-month MMT retention rate in China is substantially lower than programs in other developed (60-85% [22,114,115,116]) and developing countries settings (62-82% [117,118]).…”

The impact of needle and syringe provision and opiate substitution therapy on the incidence of hepatitis C virus in injecting drug users: pooling of UK evidence

“…those who had injected in the last 4 weeks) and thus we will have under‐represented those who cease injecting during treatment in the analysis. In line with previous evidence, we show that OST and NSP, especially in combination, are associated with reductions in injecting risk [16,17,19].…”

Impact of methadone on drug use and risky sex in China

“…Also consistent with the above consensus view, current enrollment in MMT was related to a greater reduction in drug use and injection than past enrollment in MMT (Baker, Kochan, Dixon, Wodak, & Heather, 1995). Our data also suggest that MMT may reduce risky sexual behaviors, a finding that is somewhat controversial in the literature (Abbott, Moore, Weller, & Delaney, 1998;Gowing et al, 2004;Magura, Rosenblum, & Rodriguez, 1998;Sorensen & Copeland, 2000). Our subjects who had participated in MMT may have had more chances to receive HIV risk reduction information and counseling, and this may explain why the MMT group was less likely to have multiple sexual partners and to have unprotected sex.…”

Methadone Maintenance Treatment Participant Retention and Behavioural Effectiveness in China: A Systematic Review and Meta-Analysis

“…The phenomenon of early drop-out is consistent with findings in international settings [112,113]. In comparison, the 12-month MMT retention rate in China is substantially lower than programs in other developed (60-85% [22,114,115,116]) and developing countries settings (62-82% [117,118]).…”