Substantiation of the operating life of gas piezosensors in detection of vapors of organic compounds

Кучменко, Т. А.; Шуба, А. А.; Drozdova, E. V.

doi:10.1134/s10704272150120150

Cited by 6 publications

(10 citation statements)

References 10 publications

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“…Films of 18C6, Tween were chosen for the detection of carboxylic and hydroxy acids [ 47 , 48 ], and MCNT, BCB, MR for ammonia and amines [ 49 , 50 , 51 ]. PEGSb was selected for detection of acids, alcohols, ketones [ 52 , 53 ], and TX-100 for nitrogen- and sulfur-containing compounds [ 54 , 55 ]. Moreover, the selected films are stable for at least a year when analyzing small amounts of volatile substances [ 53 ].…”

Section: Methodsmentioning

confidence: 99%

“…PEGSb was selected for detection of acids, alcohols, ketones [ 52 , 53 ], and TX-100 for nitrogen- and sulfur-containing compounds [ 54 , 55 ]. Moreover, the selected films are stable for at least a year when analyzing small amounts of volatile substances [ 53 ]. Therefore, the resulting array should be effective for solving the problem.…”

Section: Methodsmentioning

confidence: 99%

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Noninvasive Detection of Bacterial Infection in Children Using Piezoelectric E-Nose

Кучменко

Menzhulina

Шуба

2022

Sensors

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Currently, antibiotics are often prescribed to children without reason due to the inability to quickly establish the presence of a bacterial etiology of the disease. One way to obtain additional diagnostic information quickly is to study the volatile metabolome of biosamples using arrays of sensors. The goal of this work was to assess the possibility of using an array of chemical sensors with various sensitive coatings to determine the presence of a bacterial infection in children by analyzing the equilibrium gas phase (EGP) of urine samples. The EGP of 90 urine samples from children with and without a bacterial infection (urinary tract infection, soft tissue infection) was studied on the “MAG-8” device with seven piezoelectric sensors in a hospital. General urine analysis with sediment microscopy was performed using a Uriscan Pro analyzer and using an Olympus CX31 microscope. After surgical removal of the source of inflammation, the microbiological studies of the biomaterial were performed to determine the presence and type of the pathogen. The most informative output data of an array of sensors have been established for diagnosing bacterial pathology. Regression models were built to predict the presence of a bacterial infection in children with an error of no more than 15%. An indicator of infection is proposed to predict the presence of a bacterial infection in children with a high sensitivity of 96%.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Noninvasive Detection of Bacterial Infection in Children Using Piezoelectric E-Nose

Кучменко

Menzhulina

Шуба

2022

Sensors

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“…The instrument software recorded the integral responses of sensors (∆ F i , Hz) versus time in the form of chronofrequency patterns and their analytical signals (∆ F max, i ) as maximum changes in the sensor responses during the measurement, which were automatically determined in the software based on the chronofrequency patterns [ 22 ]. The sensors were fabricated in accordance with previously described procedures [ 23 ].…”

Section: Methodsmentioning

confidence: 99%

“…The sensors were chosen to make an array based on their high sensitivity to various classes of volatile substances, including the biomarkers of diseases in urine [ 7 – 12 ]: DCH18C6 and Tween-40 films were chosen for the detection of carboxylic and hydroxy acids [ 24 , 25 ]; MWCNTs, BCB, and MR were used for ammonia and structurally different amines [ 26 – 28 ]; PEGSb was used for ketones and organic acids [ 24 , 29 , 30 ]; and TX-100 was used for nitrogen- and sulfur-containing compounds [ 30 , 31 ]. Moreover, the selected films were stable for at least a year in the analysis of small amounts of volatile substances [ 22 ] contained in biosamples. Therefore, the resulting array should be effective for solving the problem.…”

Section: Methodsmentioning

confidence: 99%

On a Correlation between the Results of In-Hospital Analysis of Biosamples from Children Performed Using Standard Methods and an Array of Piezosensors

et al. 2022

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A rapid procedure for obtaining information on changes in particular characteristics of urine as the most frequently taken biosample is presented. The relationship between the output data of an array of piezoelectric sensors based on different micro- and nanostructured phases and the standard characteristics of clinical urine analysis is discussed. Volatile organic compounds identified in an equilibrium headspace gas phase of the samples with deviations from normal characteristics of clinical urine analysis are considered. The tetrachoric correlation coefficients and associations between the parameters of a sensor array and standard characteristics were calculated. A minimum set of calculated parameters of an electronic nose for the rapid in-hospital monitoring of changes in the patient’s condition in the course of therapy or medical examination was recognized. A fast and economically affordable method was developed for the monitoring of body state characteristics using the profile of volatile urine compounds obtained with an electronic nose based on piezosensors. Two versions, a color scale and a table, were proposed for presenting the electronic nose data; they can be used even by specially untrained personnel for the rapid and easy assessment of the most important urine analysis data (protein, glucose, mucus, and bacteria). The method developed makes it possible to quickly (the time of a measurement is 120 s) perform the daily monitoring of patient’s condition to avoid an unnecessary burden on the laboratory and to increase the physician’s awareness of the dynamics of the patient’s condition and facilitate the choice of treatment tactics. This method can be used for clinical examinations in polyclinics and feldsher’s stations, and it will significantly shorten the time taken to obtain screening and diagnostic information on disruptions in the body, in particular, at the initial stages of diseases.

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“…К многомерным аналитическим сигналам относятся отклики мультисенсорных систем типа искусственных "носа, глаза, языка". Для таких систем не характерны, но возможны традиционные качественный (идентификация отдельных компонентов сложных смесей) и количественный (определение содержания каждого компонента) анализ [1][2][3][4][5]. Для сравнения двух и более проб, для установления причин возможных различий их состояния применяют метод хемометрикиметод обработки сразу всех матриц выходных данных.…”

Section: Introductionunclassified

Intensification of data processing and obtaining new information on multidimensional signals of the "electronic nose"

Копаев

Murakhovskii

Кучменко

2020

Vestn. Voronež. gos. univ. inž. tehnol.

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This study describes the ways to optimize the stage of processing multidimensional data of simulation systems with an integrated analytical signal such as an electronic nose. Programming models are presented in Exel tables for calculating additional parameters of the qualitative composition of a mixture of gases and vapors. Programming spreadsheets greatly simplifies the processing of the initial data of a set of sensors and allows you to quickly get new parameters to characterize the composition of the smell of samples. The formulas for calculating 4 additional characteristics are presented: identification parameters of sorption, kinetic parameter, sorption parameter for 3 sensors, mass fraction of components, mainly sorbed on each sensor in the array of electronic nose, and Pearson's similarity parameter for sets of these characteristics in order to compare the multi-component composition of the odor analyzed samples. The example of analyzing the smell of human skin shows the possibility of developing software for personal devices. The software includes the calculation of the characteristics of the proposed models and the visualization of their sets for easy perception by untrained users. The software allows you to quickly process data from the device, to present the possible causes of the deviation of the state from the average statistical norms. For a set of identification parameters of sorption, the boundaries of numerical values are defined, which characterize the normal functioning of the organism as a whole, individual organs and systems. When a calculated parameter enters these boundaries in the state diagram, it is colored green. The numerical limits of parameters and for anomalous states are determined. When the values of the calculated parameters fall into these intervals, on the state sphere, the zones of the corresponding parameters are colored yellow or red.So, untrained users easily perceive information without complex processing of multi-dimensional data.

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Substantiation of the operating life of gas piezosensors in detection of vapors of organic compounds

Cited by 6 publications

References 10 publications

Noninvasive Detection of Bacterial Infection in Children Using Piezoelectric E-Nose

Noninvasive Detection of Bacterial Infection in Children Using Piezoelectric E-Nose

On a Correlation between the Results of In-Hospital Analysis of Biosamples from Children Performed Using Standard Methods and an Array of Piezosensors

Intensification of data processing and obtaining new information on multidimensional signals of the "electronic nose"

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