Substance P downregulates expression of the high affinity IgE receptor (FcεRI) by human mast cells

McCary, Christine; Tancowny, Brian P.; Catalli, Adriana; Grammer, Leslie C.; Harris, Kathleen E.; Schleimer, Robert P.; Kulka, Marianna

doi:10.1016/j.jneuroim.2009.12.006

Cited by 27 publications

(25 citation statements)

References 31 publications

(33 reference statements)

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“…Neurons and activated structural cells are capable of influencing the immune response through the release of cytokines and soluble mediators. One hypothesis could be a link with the production of substance P. This molecule plays a role in smooth muscle contraction, is elevated in the BALF of asthmatics (29,30), and downregulates the IgE receptor expression on mast cells (31). Furthermore, the induction of substance P in allergic asthma is dependant on another neurotrophin, NGF (32).…”

Section: Discussionmentioning

confidence: 99%

Increased Th2 Cytokine Secretion, Eosinophilic Airway Inflammation, and Airway Hyperresponsiveness in Neurturin-Deficient Mice

Michel

Thérésine

Poli

et al. 2011

The Journal of Immunology

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Neurotrophins such as nerve growth factor and brain-derived neurotrophic factor have been described to be involved in the pathogenesis of asthma. Neurturin (NTN), another neurotrophin from the glial cell line-derived neurotrophic factor family, was shown to be produced by human immune cells: monocytes, B cells, and T cells. Furthermore, it was previously described that the secretion of inflammatory cytokines was dramatically stimulated in NTN knockout (NTN−/−) mice. NTN is structurally similar to TGF-β, a protective cytokine in airway inflammation. This study investigates the implication of NTN in a model of allergic airway inflammation using NTN−/− mice. The bronchial inflammatory response of OVA-sensitized NTN−/− mice was compared with wild-type mice. Airway inflammation, Th2 cytokines, and airway hyperresponsiveness (AHR) were examined. NTN−/− mice showed an increase of OVA-specific serum IgE and a pronounced worsening of inflammatory features. Eosinophil number and IL-4 and IL-5 concentration in the bronchoalveolar lavage fluid and lung tissue were increased. In parallel, Th2 cytokine secretion of lung draining lymph node cells was also augmented when stimulated by OVA in vitro. Furthermore, AHR was markedly enhanced in NTN−/− mice after sensitization and challenge when compared with wild-type mice. Administration of NTN before challenge with OVA partially rescues the phenotype of NTN−/− mice. These findings provide evidence for a dampening role of NTN on allergic inflammation and AHR in a murine model of asthma.

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Section: Discussionmentioning

confidence: 99%

Increased Th2 Cytokine Secretion, Eosinophilic Airway Inflammation, and Airway Hyperresponsiveness in Neurturin-Deficient Mice

Michel

Thérésine

Poli

et al. 2011

The Journal of Immunology

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“…In addition, SP can enhance the innate immune response to bacterial infections by upregulating TLR2 expression on mast cells (LAD2) . On the other hand, SP can also downregulate FcεRI expression on human mast cells (LAD2 and hPDMC), implying its role in the modulation of IgE-mediated allergic diseases (McCary et al, 2010). It has been established that SP activation of murine mast cells is NK1R mediated (Kulka et al, 2008;van der Kleij et al, 2003).…”

Section: Substance Pmentioning

confidence: 99%

Non-IgE mediated mast cell activation

Blokhuis

Garssen

et al. 2016

European Journal of Pharmacology

151

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“…Previous studies have indicated that intramural injection of substance P or selective neurokinin-1 receptor (SPR) agonist act on nervous system by interact with neurotransmitters. For example, electrophysiological studies revealed that substance P excited nigral dopaminergic neurons [18].Substance P has also been revealed to promote dopamine release from striatal dopamine terminals [19]- [20], which may be involved in maintaining the integrity of neuronal populations [21].…”

Section: A Sp Spr and Nervous Systemmentioning

confidence: 99%

Function of Substance P and Substance P Receptor in Exercise

Xu¹,

Xie²,

Li³

et al. 2013

IJAPM

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Abstract-Based on many studies, this paper discusses the relationship between Substance P, Substance P receptor and exercise. There is good evidence to support the role for SP in nociception, inflammation, glandular secretions, and allergic reactions and in the control of gastrointestinal, respiratory and cardiovascular smooth muscle. It elucidates the role of SP and SPR on exercise from the nervous system and muscle. It concludes that comprehensive study on SP and SPR may be the key to sports and sports-related issues.

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Substance P downregulates expression of the high affinity IgE receptor (FcεRI) by human mast cells

Cited by 27 publications

References 31 publications

Increased Th2 Cytokine Secretion, Eosinophilic Airway Inflammation, and Airway Hyperresponsiveness in Neurturin-Deficient Mice

Increased Th2 Cytokine Secretion, Eosinophilic Airway Inflammation, and Airway Hyperresponsiveness in Neurturin-Deficient Mice

Non-IgE mediated mast cell activation

Function of Substance P and Substance P Receptor in Exercise

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