Subsets of telocytes: Myocardial telocytes

Rusu, Mugurel Constantin; Hostiuc, Sorin; Vrapciu, Alexandra Diana; Mogoantă, Laurențiu; Mănoiu, Vasile Sorin; Grigoriu, Florentina

doi:10.1016/j.aanat.2016.09.006

Cited by 34 publications

(27 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, it was repeatedly stated that "TCs form a threedimensional labyrinthine network" [Popescu and Faussone-Pellegrini, 2010;Ibba-Manneschi et al, 2016], although this statement was solely based on bidimensional cuts. Furthermore, myocardial endothelial cells (ECs) appear identical to those cells that previous TEM studies have suggested to be myocardial TCs [Rusu et al, 2017a].…”

Section: Tc Markersmentioning

confidence: 65%

“…Therefore, the c-kit+ and/or sca-1+ TC-like cells identified by means of light microscopy could also be TC-like cardiac stem/progenitor cells that were not tested for other specific markers, such as Isl-1, or other markers of mesenchymal stem cells. Identifying the molecular and/or ultrastructural markers of ECs in TC-like cells [Rusu et al, 2017a;Petrea et al, 2018aPetrea et al, , 2018bRusu et al, 2018a] would fit within the cardiac stem niche, wherein the potential for the endothelial differentiation capacity of sca-1+ cardiac progenitor cells was previously demonstrated [Hoch et al, 2011].…”

Section: Expression Of Stem/progenitor Markers In Cardiac Tcs: the Vamentioning

confidence: 99%

See 1 more Smart Citation

Myocardial Telocyte-Like Cells: A Review Including New Evidence

Iancu

Rusu

Mogoantă

et al. 2018

Cells Tissues Organs

View full text Add to dashboard Cite

Telocytes (TCs) are a controversial cell type characterized by the presence of a particular kind of prolongations, known as telopodes, which are long, thin, and moniliform. A number of attempts has been made to establish the molecular phenotype of cardiac TCs (i.e., expression of c-kit, CD34, vimentin, PDGRFα, PDGRFβ, etc.). We designed an immunohistochemical study involving cardiac tissue samples obtained from 10 cadavers with the aim of determining whether there are TC-like interstitial cells that populate the interstitial space other than the mural microvascular cells. We applied the markers for CD31, CD34, PDGRFα, CD117/c-kit, and α-smooth muscle actin (α-SMA). We found that, in relation to two-dimensional cuts, the endothelial tubes could be misidentified as TC-like cells, the difference being the positive identification of endothelial lumina. Moreover, we found that cardiac pericytes express PDGRFα, CD117/c-kit, and α-SMA, and that they could also be misidentified as TCs when using light microscopy. We reviewed the respective values of the previously identified markers for achieving a clear-cut identification of cardiac TCs, highlighting the critical lack of specificity.

show abstract

Section: Tc Markersmentioning

confidence: 65%

Section: Expression Of Stem/progenitor Markers In Cardiac Tcs: the Vamentioning

confidence: 99%

Myocardial Telocyte-Like Cells: A Review Including New Evidence

Iancu

Rusu

Mogoantă

et al. 2018

Cells Tissues Organs

View full text Add to dashboard Cite

show abstract

“…Ivey and Tallquist (2016), cell biologists from the University of Hawaii, also view the terms 'telocytes' and 'fibroblasts' as merely synonyms that can be used interchangeably. Moreover, Romanian scientists from Carol Davila University in Bucharest, the 'home' university of telocyte discovery, reported that at least one subpopulation of telocytes in the myocardium can be derived from endothelial cells (Rusu et al 2017). The authors even conceded that cells previously described as telocytes in electron micrographs of the myocardium might actually represent endothelial cells.…”

Section: Question 1 Are Telocytes Truly An Individual/unique/new Celmentioning

confidence: 99%

Recently discovered interstitial cells termed telocytes: distinguishing cell-biological and histological facts from fictions

et al. 2018

View full text Add to dashboard Cite

“…However, similar cells were found in perivascular locations by Majno in 1965 and were indicated as "veil cells" [14], as previously discussed [17,21]. The hypothesis of endothelialderived dental stem/progenitor cells is in accordance with previous evidence of dental fibroblastoid and perivascular cells capable of differentiation into odontoblasts [6] as well as with evidence of endothelial-specific Weibel-Palade bodies in pericytes as well as in pericytes-deriving immediate perivascular transitional cells within the dental pulp niche [2].…”

Section: Introductionmentioning

confidence: 67%

Endothelial expression of c-kit and CD68 in dental follicles of human impacted third molars

2018

View full text Add to dashboard Cite

Periodontal tissue remnants of odontogenesis constitute the dental follicle (DF) which is actually considered a stem niche in adults. However, potentialities of local endothelia within this niche seem overlooked. We thus aimed at testing the endothelial cells expression of c-kit, the progenitor cells marker, and CD68, commonly regarded as a monocyte/macrophage marker, in human DFs. We performed an immunohistochemical study using these two markers which were applied on samples collected from ten adult patients. The markers were positively expressed in endothelial cells, as well as in spindle-shaped stromal cells of the DF.The origin of DF stem or progenitor cells needs reviewing in the light of these findings, as endothelium could be a donor site for niche inhabitants.

show abstract

Subsets of telocytes: Myocardial telocytes

Cited by 34 publications

References 47 publications

Myocardial Telocyte-Like Cells: A Review Including New Evidence

Myocardial Telocyte-Like Cells: A Review Including New Evidence

Recently discovered interstitial cells termed telocytes: distinguishing cell-biological and histological facts from fictions

Endothelial expression of c-kit and CD68 in dental follicles of human impacted third molars

Contact Info

Product

Resources

About